(2E)-3-(4-Bromophenyl)-1-(2-methyl-4-phenyl-3-quinolyl)prop-2-en-1-one

The conformation about the ethene bond [1.316 (3) Å] in the title compound, C25H18BrNO, is E. The quinoline ring forms dihedral angles of 67.21 (10) and 71.68 (10)° with the benzene and bromo-substituted benzene rings, respectively. Highlighting the non-planar arrangement of aromatic rings, the dihedral angle formed between the benzene rings is 58.57 (12)°.

[1]  Louis J. Farrugia,et al.  ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI) , 1997 .

[2]  G. Kidder,et al.  Antiprotozoal 4-aryloxy-2-aminoquinolines and related compounds. , 1970, Journal of medicinal chemistry.

[3]  J. Michael.  Quinoline, quinazoline and acridone alkaloids. , 2001, Natural product reports.

[4]  良二 上田.  J. Appl. Cryst.の発刊に際して , 1970 .

[5]  G. Sheldrick.  A short history of SHELX. , 2008, Acta crystallographica. Section A, Foundations of crystallography.

[6]  C. Tzeng,et al.  Synthesis and antibacterial evaluation of certain quinolone derivatives. , 2001, Journal of medicinal chemistry.

[7]  Anthony L. Spek,et al.  Structure validation in chemical crystallography , 2009, Acta crystallographica. Section D, Biological crystallography.

[8]  B. Kalluraya,et al.  Synthesis and pharmacological properties of some quinoline derivatives. , 1998, Farmaco.

[9]  G Roma,et al.  1,8-Naphthyridines IV. 9-substituted N,N-dialkyl-5-(alkylamino or cycloalkylamino) [1,2,4]triazolo[4,3-a][1, 8]naphthyridine-6-carboxamides, new compounds with anti-aggressive and potent anti-inflammatory activities. , 2000, European journal of medicinal chemistry.

[10]  F. Matsuda,et al.  Total Synthesis of (±)-Virantmycin and Determination of Its Stereochemistry , 2010 .

[11]  S. Campbell,et al.  2,4-Diamino-6,7-dimethoxyquinoline derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents. , 1988, Journal of medicinal chemistry.

[12]  J. Dimmock,et al.  Bioactivities of chalcones. , 1999, Current medicinal chemistry.

[13]  A. Zilberstein,et al.  A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. , 1994, Journal of medicinal chemistry.