Mouse mammary tumor virus: a cause of breast cancer in humans?

Summary The mouse mammary tumour virus (MMTV), a B-type retrovirus, is known to be the most common cause of breast cancer in mice. However, its role in human breast cancer is very controversial. Here we review the evidence that supports the role of this virus in causing human breast cancer. It’s historical background, its possible transmission from mice to human and its mechanism of actions have also been reviewed.

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