The quest for interpretable models of neural population activity

Many aspects of brain function arise from the coordinated activity of large populations of neurons. Recent developments in neural recording technologies are providing unprecedented access to the activity of such populations during increasingly complex experimental contexts; however, extracting scientific insights from such recordings requires the concurrent development of analytical tools that relate this population activity to system-level function. This is a primary motivation for latent variable models, which seek to provide a low-dimensional description of population activity that can be related to experimentally controlled variables, as well as uncontrolled variables such as internal states (e.g. attention and arousal) and elements of behavior. While deriving an understanding of function from traditional latent variable methods relies on low-dimensional visualizations, new approaches are targeting more interpretable descriptions of the components underlying system-level function.