Word-of-Mouth Innovation: Hypothesis Generation for Supplement Repurposing based on Consumer Reviews

Dietary supplements remain a relatively underexplored source for drug repurposing. A systematic approach to soliciting responses from a large consumer population is desirable to speed up innovation. We tested a workflow that mines unexpected benefits of dietary supplements from massive consumer reviews. A (non-exhaustive) list of regular expressions was used to screen over 2 million reviews on health and personal care products. The matched reviews were manually analyzed, and one supplement-disease pair was linked to biological databases for enriching the hypothesized association. The regular expressions found 169 candidate reviews, of which 45.6% described unexpected benefits of certain dietary supplements. The manual analysis showed some of the supplement-disease associations to be novel or in agreement with evidence published later in the literature. The hypothesis enrichment was able to identify meaningful function similarity between the supplement and the disease. The results demonstrated value of the workflow in identifying candidates for supplement repurposing.

[1]  Helen E. Parkinson,et al.  The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog) , 2016, Nucleic Acids Res..

[2]  H. Koh,et al.  Identification of a new sildenafil analogue in a health supplement. , 2011, Journal of pharmaceutical and biomedical analysis.

[3]  Juancarlos Chan,et al.  Gene Ontology Consortium: going forward , 2014, Nucleic Acids Res..

[4]  Charles C. Persinger,et al.  How to improve R&D productivity: the pharmaceutical industry's grand challenge , 2010, Nature Reviews Drug Discovery.

[5]  C. Mattingly,et al.  The Comparative Toxicogenomics Database (CTD). , 2003, Environmental health perspectives.

[6]  Carol Friedman,et al.  Information theory applied to the sparse gene ontology annotation network to predict novel gene function , 2007, ISMB/ECCB.

[7]  Anton van den Hengel,et al.  Image-Based Recommendations on Styles and Substitutes , 2015, SIGIR.

[8]  Son Doan,et al.  Mining Health-Related Issues in Consumer Product Reviews by Using Scalable Text Analytics , 2016, Biomedical informatics insights.

[9]  M. Pimentel,et al.  Gender distribution in irritable bowel syndrome is proportional to the severity of constipation relative to diarrhea. , 2010, Gender medicine.

[10]  K. Oishi,et al.  Dietary heat-killed Lactobacillus brevis SBC8803 promotes voluntary wheel-running and affects sleep rhythms in mice. , 2014, Life sciences.

[11]  Jure Leskovec,et al.  Inferring Networks of Substitutable and Complementary Products , 2015, KDD.

[12]  P. Wolfgram,et al.  Long-term effects of recombinant human growth hormone therapy in children with Prader–Willi syndrome , 2013, Current opinion in pediatrics.

[13]  M. Heitkemper,et al.  Gender differences in irritable bowel syndrome. , 2002, Gastroenterology.

[14]  M. Costandi.  Citizen microbiome , 2013, Nature Biotechnology.

[15]  W. Eisenreich,et al.  Identification of novel sildenafil-analogues in an adulterated herbal food supplement. , 2011, Journal of pharmaceutical and biomedical analysis.

[16]  Y. Nakakita,et al.  Effect of dietary heat-killed Lactobacillus brevis SBC8803 (SBL88™) on sleep: a non-randomised, double blind, placebo-controlled, and crossover pilot study. , 2016, Beneficial microbes.