Differential effects of electrical stimulation and lesions of the hippocampus and adjacent regions upon attack behavior in cats.

Abstract The role of the hippocampus and lateral nucleus of the amygdala in attack behavior elicited by electrical stimulation of the hypothalamus was assessed. The major finding was that stimulation of the ventral hippocampus and adjacent regions significantly lowered latencies to attack, whereas stimulation of the dorsal hippocampus increased attack latencies. A functional division of the hippocampus was indicated by the results. Lesions of the ventral hippocampus and lateral amygdala increased attack latencies. Dorsal hippocampal lesions did not reveal a consistent pattern of results.

[1]  W. R. Adey,et al.  Hippocampal slow waves. Distribution and phase relationships in the course of approach learning. , 1960, Archives of neurology.

[2]  V. Mountcastle,et al.  Some forebrain mechanisms involved in expression of rage with special reference to suppression of angry behavior. , 1948, Research publications - Association for Research in Nervous and Mental Disease.

[3]  K. R. Hughes.  Dorsal and ventral hippocampus lesions and maze learning: influence of preoperative environment. , 1965, Canadian journal of psychology.

[4]  A. Kling,et al.  Effect of hypothalamic lesions on the amygdala syndrome in the cat. , 1958, A.M.A. archives of neurology and psychiatry.

[5]  B. Cragg.  Olfactory and other afferent connections of the hippocampus in the rabbit, rat, and cat. , 1961, Experimental neurology.

[6]  P. J. Harman,et al.  On the relation of the hippocampal‐fornix system to the control of rage responses in cats , 1954, The Journal of comparative neurology.

[7]  Charles D. Wood.  Behavioral changes following discrete lesions of temporal lobe structures , 1958, Neurology.

[8]  J. Orbach,et al.  Injury to the limbic system and associated structures in cats. Chronic behavioral and physiological effects. , 1960, Archives of general psychiatry.

[9]  REGIONAL DIFFERENCES IN THE HIPPOCAMPUS OF THE CAT. II. PROJECTIONS OF THE DORSAL AND VENTRAL HIPPOCAMPUS. , 1964, Electroencephalography and clinical neurophysiology.

[10]  M. David Egger,et al.  Further studies on the effects of amygdaloid stimulation and ablation on hypothalamically elicited attack behavior in cats. , 1967, Progress in brain research.

[11]  J. P. Flynn,et al.  Facilitation of attack behavior by stimulation of the midbrain of cats. , 1967, Brain research.

[12]  H. Nakao.  HYPOTHALAMIC EMOTIONAL REACTIVITY AFTER AMYGDALOID LESIONS IN CATS , 1960, Folia psychiatrica et neurologica japonica.

[13]  A. Kling,et al.  Behavioral changes following rhinencephalic injury in cat. , 1953, Journal of neurophysiology.

[14]  P. Maclean,et al.  Electrical and chemical stimulation of frontotemporal portion of limbic system in the waking animal. , 1953, Electroencephalography and clinical neurophysiology.

[15]  H. Jasper,et al.  A stereotaxic atlas of the diencephalon of the cat , 1960 .

[16]  P. Andersen,et al.  Stimulation of the Hippocampus and Medial Cortical Areas in Unanesthetized Cats , 1953, Neurology.

[17]  W. Nauta,et al.  Hippocampal projections and related neural pathways to the midbrain in the cat. , 1958, Brain : a journal of neurology.

[18]  C. Clemente,et al.  Experimentally induced epilepsy in the cat with injury of cornu Ammonis. , 1957, A.M.A. archives of neurology and psychiatry.

[19]  H. Klüver,et al.  PRELIMINARY ANALYSIS OF FUNCTIONS OF THE TEMPORAL LOBES IN MONKEYS , 1939 .

[20]  J. W. Papez.  A PROPOSED MECHANISM OF EMOTION , 1937 .

[21]  P. Maclean.  Psychosomatic Disease and the "Visceral Brain": Recent Developments Bearing on the Papez Theory of Emotion , 1949, Psychosomatic medicine.

[22]  James L Olds,et al.  Self-stimulation of hippocampus in rats. , 1966, Journal of comparative and physiological psychology.

[23]  G Raisman,et al.  The central olfactory connexions. , 1965, Journal of anatomy.

[24]  J. P. Flynn,et al.  Directed attack elicited from hypothalamus. , 1962, Archives of neurology.

[25]  J. P. Flynn,et al.  EFFECTS OF ELECTRICAL STIMULATION OF THE AMYGDALA ON HYPOTHALAMICALLY ELICITED ATTACK BEHAVIOR IN CATS. , 1963, Journal of neurophysiology.