Development of miniature mass spectrometry systems for bioanalysis outside the conventional laboratories.

Mass spectrometry (MS) is known for highly specific and sensitive analysis. The general applicability of this technique makes it a good candidate for biological applications over a much broader range than is now the case. The limiting factors preventing MS from being applied at the biologist's bench or in a physician's office are identified as the large size of the systems, as well as the complicated analytical procedures required. An approach for developing miniature MS analysis systems with simplified operational procedures is described and the associated technical developments are discussed.

[1]  Anthony B. Costa,et al.  Multivariate statistical differentiation of renal cell carcinomas based on lipidomic analysis by ambient ionization imaging mass spectrometry , 2010, Analytical and bioanalytical chemistry.

[2]  G. V. Van Berkel,et al.  Comparison of drug distribution images from whole-body thin tissue sections obtained using desorption electrospray ionization tandem mass spectrometry and autoradiography. , 2008, Analytical chemistry.

[3]  C. Sears,et al.  Bacterial oncogenesis in the colon. , 2013, Future microbiology.

[4]  Bradley L Ackermann,et al.  Current applications of liquid chromatography/mass spectrometry in pharmaceutical discovery after a decade of innovation. , 2008, Annual review of analytical chemistry.

[5]  Nicholas E. Manicke,et al.  Direct and quantitative analysis of underivatized acylcarnitines in serum and whole blood using paper spray mass spectrometry , 2012, Analytical and Bioanalytical Chemistry.

[6]  Zheng Ouyang,et al.  Mini 12, Miniature Mass Spectrometer for Clinical and Other Applications—Introduction and Characterization , 2014, Analytical chemistry.

[7]  Nicholas E. Manicke,et al.  Silica coated paper substrate for paper-spray analysis of therapeutic drugs in dried blood spots. , 2012, Analytical chemistry.

[8]  Zheng Ouyang,et al.  Rectilinear ion trap: concepts, calculations, and analytical performance of a new mass analyzer. , 2004, Analytical chemistry.

[9]  R. Cooks,et al.  Ambient Mass Spectrometry , 2006, Science.

[10]  Anthony B. Costa,et al.  New ionization methods and miniature mass spectrometers for biomedicine: DESI imaging for cancer diagnostics and paper spray ionization for therapeutic drug monitoring. , 2011, Faraday discussions.

[11]  R. Cooks,et al.  Development of capabilities for imaging mass spectrometry under ambient conditions with desorption electrospray ionization (DESI) , 2007 .

[12]  Zheng Ouyang,et al.  Miniature mass spectrometers. , 2009, Annual review of analytical chemistry.

[13]  R. Cooks,et al.  Direct analysis of biological tissue by paper spray mass spectrometry. , 2011, Analytical chemistry.

[14]  J. Nilles,et al.  Quantitation of chemical warfare agents using the direct analysis in real time (DART) technique. , 2009, Analytical Chemistry.

[15]  R. Cooks,et al.  Enabling quantitative analysis in ambient ionization mass spectrometry: internal standard coated capillary samplers. , 2013, Analytical chemistry.

[16]  Zheng Ouyang,et al.  Ambient Mass Spectrometry , 2006, Science.

[17]  R. Cooks,et al.  Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization , 2004, Science.

[18]  T. Seyfried,et al.  Differentiating N-linked glycan structural isomers in metastatic and nonmetastatic tumor cells using sequential mass spectrometry. , 2008, Glycobiology.

[19]  J. Wiseman,et al.  Evaluation and performance of desorption electrospray ionization using a triple quadrupole mass spectrometer for quantitation of pharmaceuticals in plasma. , 2010, Rapid communications in mass spectrometry : RCM.

[20]  Alexandra J. Golby,et al.  Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors , 2013, Proceedings of the National Academy of Sciences.

[21]  K. Ligon,et al.  Classifying human brain tumors by lipid imaging with mass spectrometry. , 2012, Cancer research.

[22]  R. Cooks,et al.  Biological tissue diagnostics using needle biopsy and spray ionization mass spectrometry. , 2011, Analytical chemistry.

[23]  Z. Ouyang,et al.  Mass spectrometry imaging for biomedical applications , 2013, Analytical and Bioanalytical Chemistry.

[24]  Z. Ouyang,et al.  Simulation of Rarefied Gas Flows in Atmospheric Pressure Interfaces for Mass Spectrometry Systems , 2013, Journal of The American Society for Mass Spectrometry.

[25]  R. Cooks,et al.  Development of a mass spectrometry sampling probe for chemical analysis in surgical and endoscopic procedures. , 2013, Analytical chemistry.

[26]  R. Cooks,et al.  Rapid screening of anabolic steroids in urine by reactive desorption electrospray ionization. , 2007, Analytical chemistry.

[27]  Zheng Ouyang,et al.  Breaking the pumping speed barrier in mass spectrometry: discontinuous atmospheric pressure interface. , 2008, Analytical chemistry.

[28]  Jin-Ming Lin,et al.  Development, characterization, and application of paper spray ionization. , 2010, Analytical chemistry.

[29]  Akos Vertes,et al.  Ambient mass spectrometry for in vivo local analysis and in situ molecular tissue imaging , 2012 .

[30]  R. Zenobi,et al.  Evaluation of extractive electrospray ionization and atmospheric pressure chemical ionization for the detection of narcotics in breath , 2011 .

[31]  Nicholas E. Manicke,et al.  Quantitative Analysis of Therapeutic Drugs in Dried Blood Spot Samples by Paper Spray Mass Spectrometry: An Avenue to Therapeutic Drug Monitoring , 2011, Journal of the American Society for Mass Spectrometry.

[32]  Richard M Caprioli,et al.  Mass spectrometric profiling of intact biological tissue by using desorption electrospray ionization. , 2005, Angewandte Chemie.

[33]  R. Cooks,et al.  Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry. , 2006, Angewandte Chemie.

[34]  J. Loo,et al.  Electrospray-assisted laser desorption ionization mass spectrometry (ELDI-MS) with an infrared laser for characterizing peptides and proteins. , 2010, The Analyst.

[35]  Nicholas E. Manicke,et al.  Direct quantitative analysis of nicotine alkaloids from biofluid samples using paper spray mass spectrometry. , 2013, Analytical chemistry.

[36]  Z. Ouyang,et al.  Analysis of Biological Samples Using Paper Spray Mass Spectrometry: An Investigation of Impacts by the Substrates, Solvents and Elution Methods , 2013, Chromatographia.

[37]  Jentaie Shiea,et al.  Ambient ionization mass spectrometry. , 2010, Annual review of analytical chemistry.

[38]  Matthew A Kirleis,et al.  Autonomous in situ analysis and real-time chemical detection using a backpack miniature mass spectrometer: concept, instrumentation development, and performance. , 2014, Analytical chemistry.

[39]  R. Cooks,et al.  Quantitative paper spray mass spectrometry analysis of drugs of abuse. , 2013, The Analyst.

[40]  Olga Vitek,et al.  Multivariate statistical identification of human bladder carcinomas using ambient ionization imaging mass spectrometry. , 2011, Chemistry.

[41]  Liang Cheng,et al.  Cholesterol sulfate imaging in human prostate cancer tissue by desorption electrospray ionization mass spectrometry. , 2010, Analytical chemistry.

[42]  R. Cooks,et al.  Discrimination of human astrocytoma subtypes by lipid analysis using desorption electrospray ionization imaging mass spectrometry. , 2010, Angewandte Chemie.

[43]  Z. Ouyang,et al.  Direct Mass Spectrometry Analysis of Untreated Samples of Ultralow Amounts Using Extraction Nano-Electrospray. , 2013, Analytical methods : advancing methods and applications.

[44]  Zheng Ouyang,et al.  Design and characterization of a multisource hand-held tandem mass spectrometer. , 2008, Analytical chemistry.

[45]  Zheng Ouyang,et al.  Paper spray for direct analysis of complex mixtures using mass spectrometry. , 2010, Angewandte Chemie.

[46]  Zheng Ouyang,et al.  Handheld miniature ion trap mass spectrometers. , 2009, Analytical chemistry.

[47]  A. Vertes,et al.  Simultaneous imaging of small metabolites and lipids in rat brain tissues at atmospheric pressure by laser ablation electrospray ionization mass spectrometry. , 2010, Analytical chemistry.

[48]  Prabha Dwivedi,et al.  Mass spectrometry: recent advances in direct open air surface sampling/ionization. , 2013, Chemical reviews.

[49]  R. Cooks,et al.  Distinctive Glycerophospholipid Profiles of Human Seminoma and Adjacent Normal Tissues by Desorption Electrospray Ionization Imaging Mass Spectrometry , 2011, Journal of the American Society for Mass Spectrometry.