Monitoring of thermal treatment by linearly chirped fiber Bragg grating sensors: Feasibility assessment during laser ablation on ex vivo liver

In this work a spatially-resolved fiber optic temperature sensor has been characterized in a wide range of gradient applied on its active area (from -35 °C to +35 °C). Preliminary experiments to assess its feasibility for application in laser ablation have been performed. The sensor under test is a linearly chirped fiber Bragg grating (FBG), with 1.5 cm-length of active area. It can be considered as a chain of several FBGs, each able to sense local temperature. The sensor response to the gradient has been analyzed in terms of its spectrum width (full width at half maximum). There is a linear relationship between the full width at half maximum and the gradient, with a sensitivity of 0.0087 nm°C-1. The feasibility test using the linearly chirped FBG during laser ablation showed promising results: it is able to detect both the thermal gradients along is active area and the average temperature increment during the procedure.

[1]  Tingyun Wang,et al.  Fully distributed chirped FBG sensor and application in laser-induced interstitial thermotherapy , 2009, 2009 Asia Communications and Photonics conference and Exhibition (ACP).

[2]  Emiliano Schena,et al.  Assessment of temperature measurement error and its correction during Nd:YAG laser ablation in porcine pancreas , 2014, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[3]  H. Rhim,et al.  Recent Advances in Tumor Ablation for Hepatocellular Carcinoma , 2015, Liver Cancer.

[4]  Elfed Lewis,et al.  Intra-Tissue Pressure Measurement in Ex Vivo Liver Undergoing Laser Ablation with Fiber-Optic Fabry-Perot Probe , 2016, Sensors.

[5]  Sergio Silvestri,et al.  Temperature monitoring and lesion volume estimation during double-applicator laser-induced thermotherapy in ex vivo swine pancreas: a preliminary study , 2014, Lasers in Medical Science.

[6]  Laura Crocetti,et al.  Percutaneous ablation of hepatocellular carcinoma. , 2006, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[7]  Elfed Lewis,et al.  Fiber-optic chirped FBG for distributed thermal monitoring of ex-vivo radiofrequency ablation of liver. , 2014, Biomedical optics express.

[8]  Sergio Silvestri,et al.  Theoretical Analysis and Experimental Evaluation of Laser-Induced Interstitial Thermotherapy in Ex Vivo Porcine Pancreas , 2012, IEEE Transactions on Biomedical Engineering.

[9]  Elfed Lewis,et al.  Monitoring of radiofrequency thermal ablation in liver tissue through fibre Bragg grating sensors array , 2014 .

[10]  Christopher L Brace,et al.  Principles of and advances in percutaneous ablation. , 2011, Radiology.

[11]  T. Erdogan Fiber grating spectra , 1997 .

[12]  T. Vogl,et al.  Image-guided tumor ablation: standardization of terminology and reporting criteria--a 10-year update. , 2014, Radiology.

[13]  Sergio Silvestri,et al.  Techniques for temperature monitoring during laser-induced thermotherapy: An overview , 2013, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[14]  Sergio Silvestri,et al.  Influence of FBG sensors length on temperature measures in laser-irradiated pancreas: Theoretical and experimental evaluation , 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[15]  E Schena,et al.  Temperature monitoring during microwave ablation in ex vivo porcine livers. , 2015, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[16]  Kenneth T. V. Grattan,et al.  Fiber Optic Fluorescence Thermometry , 1994 .

[17]  Sergio Silvestri,et al.  CT-based thermometry: An overview , 2014, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.