The artificial intelligence takes the computer as the core, and has great development and innovation in the research of the interdisciplinary field. The level of artificial intelligence is high, and processing speed is fast, which can ease the burden of designers, and greatly improve the designers life quality and production efficiency. With the development process of science, more and more requirements of substation digitized designing are posed. Application Imagination on Substation Design Based on Artificial Intelligence is proposed in this paper, which can design secondary physical circuit, secondary virtual circuit and intelligent label more quality and effective.