SeqVis: Visualization of compositional heterogeneity in large alignments of nucleotides

UNLABELLED Most phylogenetic methods assume that the sequences evolved under homogeneous, stationary and reversible conditions. Compositional heterogeneity in data intended for studies of phylogeny suggests that the data did not evolve under these conditions. SeqVis, a Java application for analysis of nucleotide content, reads sequence alignments in several formats and plots the nucleotide content in a tetrahedron. Once plotted, outliers can be identified, thus allowing for decisions on the applicability of the data for phylogenetic analysis. AVAILABILITY http://www.bio.usyd.edu.au/jermiin/programs.htm.

[1]  S. Carroll,et al.  Animal Evolution and the Molecular Signature of Radiations Compressed in Time , 2005, Science.

[2]  Faisal Ababneh,et al.  Matched-pairs tests of homogeneity with applications to homologous nucleotide sequences , 2006, Bioinform..

[3]  Faisal Ababneh,et al.  The biasing effect of compositional heterogeneity on phylogenetic estimates may be underestimated. , 2004, Systematic biology.

[4]  C R Woese,et al.  Archaeal phylogeny: reexamination of the phylogenetic position of Archaeoglobus fulgidus in light of certain composition-induced artifacts. , 1991, Systematic and applied microbiology.

[5]  John Robinson,et al.  Estimation of Phylogeny Using a General Markov Model , 2005, Evolutionary bioinformatics online.

[6]  J. Adachi,et al.  Phylogenetic place of mitochondrion-lacking protozoan, Giardia lamblia, inferred from amino acid sequences of elongation factor 2. , 1995, Molecular biology and evolution.

[7]  S. Ho,et al.  Tracing the decay of the historical signal in biological sequence data. , 2004, Systematic biology.

[8]  M. Gouy,et al.  A nonhyperthermophilic common ancestor to extant life forms. , 1999, Science.

[9]  A. Bowker,et al.  A test for symmetry in contingency tables. , 1948, Journal of the American Statistical Association.

[10]  M. Steel,et al.  Recovering evolutionary trees under a more realistic model of sequence evolution. , 1994, Molecular biology and evolution.

[11]  C Cannings,et al.  Natural selection and the de Finetti diagram , 1968, Annals of human genetics.

[12]  A. Stuart A TEST FOR HOMOGENEITY OF THE MARGINAL DISTRIBUTIONS IN A TWO-WAY CLASSIFICATION , 1955 .