E2Fs and the Retinoblastoma Protein Family

[1]  C. W. Lee,et al.  Functional interaction between DP-1 and p53 , 1996, Molecular and cellular biology.

[2]  M. Vidal,et al.  Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[3]  M. Vidal,et al.  Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[4]  D. Dean,et al.  Domains A and B in the Rb pocket interact to form a transcriptional repressor motif , 1996, Molecular and cellular biology.

[5]  Goberdhan P Dimri,et al.  Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence , 1996, Journal of cellular physiology.

[6]  D. Beach,et al.  Cdc25 cell-cycle phosphatase as a target of c-myc , 1996, Nature.

[7]  X. Graña,et al.  G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4. , 1996, Oncogene.

[8]  T. Jacks,et al.  Targeted disruption of p107: functional overlap between p107 and Rb. , 1996, Genes & development.

[9]  N. Dyson,et al.  Requirements for dE2F function in proliferating cells and in post‐mitotic differentiating cells. , 1996, The EMBO journal.

[10]  Chin-Lee Wu,et al.  Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1 , 1996, Molecular and cellular biology.

[11]  N. Dyson,et al.  Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. , 1996, The EMBO journal.

[12]  A. Hatzigeorgiou,et al.  Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter , 1996, Molecular and cellular biology.

[13]  R. Weinberg,et al.  Shared role of the pRB-related p130 and p107 proteins in limb development. , 1996, Genes & development.

[14]  C. Reznikoff,et al.  Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells. , 1996, Cancer research.

[15]  J. Blanchard,et al.  Cyclin A expression is under negative transcriptional control during the cell cycle , 1996, Molecular and cellular biology.

[16]  P. Dirks,et al.  Activity of the retinoblastoma family proteins, pRB, p107, and p130, during cellular proliferation and differentiation. , 1996, Critical reviews in biochemistry and molecular biology.

[17]  J. R. Smith,et al.  Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein , 1996, Molecular and cellular biology.

[18]  A. Yee,et al.  The N-terminal Region of E2F-1 Is Required for Transcriptional Activation of a New Class of Target Promoter (*) , 1996, The Journal of Biological Chemistry.

[19]  M. Greenberg,et al.  E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation , 1996, Cell.

[20]  T. Jacks,et al.  Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1 , 1996, Cell.

[21]  R. Weinberg.  E2F and Cell Proliferation: A World Turned Upside Down , 1996, Cell.

[22]  M. Vidal,et al.  RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. , 1996, Genes & development.

[23]  M. Ewen,et al.  Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[24]  H. Handa,et al.  Activation of the retinoblastoma gene expression by Bcl-3: implication for muscle cell differentiation. , 1996, Oncogene.

[25]  J. Nevins,et al.  A role for a bent DNA structure in E2F-mediated transcription activation , 1996, Molecular and cellular biology.

[26]  C. Prives,et al.  p53: puzzle and paradigm. , 1996, Genes & development.

[27]  F. Oswald,et al.  The E2F transcription factor activates a replication-dependent human H2A gene in early S phase of the cell cycle , 1996, Molecular and cellular biology.

[28]  R. Weinberg,et al.  Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts , 1996, Molecular and cellular biology.

[29]  A. Giordano,et al.  Functional analysis of pRb2/p130 interaction with cyclins. , 1996, Cancer research.

[30]  J. Greenblatt,et al.  Three functional classes of transcriptional activation domain , 1996, Molecular and cellular biology.

[31]  J. Nevins,et al.  Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[32]  P. Fallon,et al.  Retinoblastoma protein inhibits IFN-gamma induced apoptosis. , 1996, Oncogene.

[33]  J. Nevins,et al.  A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[34]  M. Rudnicki,et al.  Cloning and expression of the Rb-related mouse p130 mRNA. , 1996, Oncogene.

[35]  A. Schulze,et al.  Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107 , 1996, Journal of virology.

[36]  Shiaw-Yih Lin,et al.  Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction , 1996, Molecular and cellular biology.

[37]  D. Livingston,et al.  Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. , 1996, Genes & development.

[38]  K. Moberg,et al.  E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry , 1996, Molecular and cellular biology.

[39]  N. Jones,et al.  E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest , 1996, Current Biology.

[40]  Guha,et al.  Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins , 1996, Molecular and cellular biology.

[41]  E. Wintersberger,et al.  Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F , 1996, Molecular and cellular biology.

[42]  R. Weinberg,et al.  Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. , 1996, Oncogene.

[43]  F. C. Lucibello,et al.  Cell Cycle Regulation of E2F Site Occupation in Vivo , 1996, Science.

[44]  N. Hay,et al.  p21 Disrupts the interaction between cdk2 and the E2F-p130 complex , 1996, Molecular and cellular biology.

[45]  J. Bartek,et al.  Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression , 1996, Molecular and cellular biology.

[46]  B. Dörken,et al.  Blocking the transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice , 1996, The Journal of experimental medicine.

[47]  S. Elledge,et al.  Cdk inhibitors in development and cancer. , 1996, Current opinion in genetics & development.

[48]  N. Heintz,et al.  Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the Chinese hamster ovary cell cycle , 1996, Molecular and cellular biology.

[49]  W. Lee,et al.  Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[50]  M. Prystowsky,et al.  Identification of an Essential Cis-Element Near the Transcription Start Site for Transcriptional Activation of the Proliferating Cell Nuclear Antigen Gene (*) , 1996, The Journal of Biological Chemistry.

[51]  D. Riley,et al.  Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[52]  E. Reddy,et al.  Transducers of life and death: TNF receptor superfamily and associated proteins. , 1996, Oncogene.

[53]  B. Gallie,et al.  Loss of Rb and Myc activation co-operate to suppress cyclin D1 and contribute to transformation. , 1996, Oncogene.

[54]  P. Farnham,et al.  Transcriptional regulation of the dihydrofolate reductase gene , 1996, BioEssays : news and reviews in molecular, cellular and developmental biology.

[55]  D. Roth,et al.  High-frequency illegitimate integration of transfected DNA at preintegrated target sites in a mammalian genome , 1996, Molecular and cellular biology.

[56]  P. Farnham,et al.  Introduction to the E2F family: protein structure and gene regulation. , 1996, Current topics in microbiology and immunology.

[57]  E. White,et al.  Life, death, and the pursuit of apoptosis. , 1996, Genes & development.

[58]  G. Peters,et al.  Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. , 1996, Advances in cancer research.

[59]  J. Nevins,et al.  Use of the E2F transcription factor by DNA tumor virus regulatory proteins. , 1996, Current topics in microbiology and immunology.

[60]  V. Richon,et al.  Changes in E2F DNA-binding activity during induced erythroid differentiation. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[61]  R. Bronson,et al.  Expression of the E2F-1/DP-1 transcription factor in murine development. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[62]  D. Livingston,et al.  Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint , 1995, Cell.

[63]  J. Nevins,et al.  Regulation of the cyclin E gene by transcription factor E2F1. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[64]  B. Wasylyk,et al.  MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest. , 1995, Oncogene.

[65]  W. Sellers,et al.  A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[66]  G. Pfeifer,et al.  In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression , 1995, Molecular and cellular biology.

[67]  J L Cleveland,et al.  E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis , 1995, Molecular and cellular biology.

[68]  E. Lam,et al.  Physical and functional interactions between p53 and cell cycle co‐operating transcription factors, E2F1 and DP1. , 1995, The EMBO journal.

[69]  A. Patel,et al.  v-Abl activates c-myc transcription through the E2F site , 1995, Molecular and cellular biology.

[70]  A. Schulze,et al.  Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[71]  Duen-Yi Huang,et al.  Different Regulation of the Human Thymidine Kinase Promoter in Normal Human Diploid IMR-90 Fibroblasts and HeLa Cells (*) , 1995, The Journal of Biological Chemistry.

[72]  D. Johnson,et al.  Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity. , 1995, Oncogene.

[73]  M. Yamaguchi,et al.  Essential Role of E2F Recognition Sites in Regulation of the Proliferating Cell Nuclear Antigen Gene Promoter during Drosophila Development (*) , 1995, The Journal of Biological Chemistry.

[74]  A. Trembleau,et al.  Isolation and characterization of a chicken homolog of the E2F-1 transcription factor. , 1995, Oncogene.

[75]  N. L. La Thangue,et al.  A new member of the DP family, DP-3, with distinct protein products suggests a regulatory role for alternative splicing in the cell cycle transcription factor DRTF1/E2F. , 1995, Oncogene.

[76]  G. Rousseau,et al.  An E2F-dependent late-serum-response promoter in a gene that controls glycolysis. , 1995, Oncogene.

[77]  P. Raychaudhuri,et al.  Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription , 1995, Molecular and cellular biology.

[78]  J. Decaprio,et al.  Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation , 1995, Molecular and cellular biology.

[79]  M. Pagano,et al.  Identification of a Myc‐dependent step during the formation of active G1 cyclin‐cdk complexes. , 1995, The EMBO journal.

[80]  A. Schulze,et al.  Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation , 1995, Journal of virology.

[81]  A. Zantema,et al.  Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells , 1995, The Journal of cell biology.

[82]  N. Goldstein,et al.  Cell cycle gene expression and E2F transcription factor complexes in human melanoma cells induced to terminally differentiate. , 1995, Oncogene.

[83]  P. Branton,et al.  Characterization of transcription factor E2F complexes during muscle and neuronal differentiation. , 1995, Oncogene.

[84]  D. Haber,et al.  The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis. , 1995, Genes & development.

[85]  F. C. Lucibello,et al.  Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. , 1995, The EMBO journal.

[86]  E. Williamson,et al.  Role for E2F1 in p210 BCR-ABL downstream regulation of c-myc transcription initiation. Studies in murine myeloid cells. , 1995, Leukemia.

[87]  E. Lam,et al.  Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster. , 1995, Journal of cell science.

[88]  Y. Nishimune,et al.  Regulation of the Mouse Histone H2A.X Gene Promoter by the Transcription Factor E2F and CCAAT Binding Protein (*) , 1995, The Journal of Biological Chemistry.

[89]  J. Nevins,et al.  Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes , 1995, Molecular and cellular biology.

[90]  X. Graña,et al.  Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). , 1995, Oncogene.

[91]  B. Dynlacht,et al.  p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. , 1995, Genes & development.

[92]  N. L. La Thangue,et al.  Molecular and functional characterisation of E2F-5, a new member of the E2F family. , 1995, Oncogene.

[93]  R. Weinberg,et al.  Growth suppression by p16ink4 requires functional retinoblastoma protein. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[94]  S. Reed,et al.  Different roles for cyclins D1 and E in regulation of the G1-to-S transition , 1995, Molecular and cellular biology.

[95]  Lingyun Zhu,et al.  Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins , 1995, Molecular and cellular biology.

[96]  S. Weintraub,et al.  Mechanism of active transcriptional repression by the retinoblastoma protein , 1995, Nature.

[97]  W. Sellers,et al.  Interaction between the retinoblastoma protein and the oncoprotein MDM2 , 1995, Nature.

[98]  Tony Kouzarides,et al.  Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein , 1995, Nature.

[99]  T. Ogihara,et al.  A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[100]  P. O’Farrell,et al.  Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. , 1995, Genes & development.

[101]  P. O’Farrell,et al.  The transcription factor E2F is required for S phase during Drosophila embryogenesis. , 1995, Genes & development.

[102]  A. Emili,et al.  Promoter-dependent Photocross-linking of the Acidic Transcriptional Activator E2F-1 to the TATA-binding Protein (*) , 1995, The Journal of Biological Chemistry.

[103]  B. Dynlacht,et al.  Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition , 1995, Nature.

[104]  J. Bartek,et al.  Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16 , 1995, Nature.

[105]  G. Wahl,et al.  Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[106]  C. Ingles,et al.  Direct transcriptional repression by pRB and its reversal by specific cyclins , 1995, Molecular and cellular biology.

[107]  C. Glass,et al.  Identification of a cell-type-specific and E2F-independent mechanism for repression of cdc2 transcription , 1995, Molecular and cellular biology.

[108]  G. Stein,et al.  Origins of G1 arrest in senescent human fibroblasts , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[109]  K. Arai,et al.  Characterization of cis-regulatory elements of the c-myc promoter responding to human GM-CSF or mouse interleukin 3 in mouse proB cell line BA/F3 cells expressing the human GM-CSF receptor. , 1995, Molecular biology of the cell.

[110]  H. Hermeking,et al.  A complex between E2F and the pRb-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformation. , 1995, Oncogene.

[111]  L. J. Veer,et al.  E2F-5, a new E2F family member that interacts with p130 in vivo , 1995, Molecular and cellular biology.

[112]  S. Chellappan,et al.  Cloning and characterization of human DP2, a novel dimerization partner of E2F. , 1995, Oncogene.

[113]  M. Imperiale,et al.  Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen , 1995, Journal of virology.

[114]  R. Kerkhoven,et al.  Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. , 1995, Genes & development.

[115]  R. Weinberg,et al.  The retinoblastoma protein and cell cycle control , 1995, Cell.

[116]  L. Lania,et al.  Differential transcriptional regulation of c-myc promoter through the same DNA binding sites targeted by Sp1-like proteins. , 1995, Oncogene.

[117]  M. Kitagawa,et al.  The interactions of E2F with pRB and with p107 are regulated via the phosphorylation of pRB and p107 by a cyclin-dependent kinase. , 1995, Oncogene.

[118]  T. Nakamura,et al.  The G1/S boundary-specific enhancer of the rat cdc2 promoter , 1995 .

[119]  Chin-Lee Wu,et al.  Copyright � 1995, American Society for Microbiology In Vivo Association of E2F and DP Family Proteins , 1995 .

[120]  T. Neuman,et al.  Expression of Rb, E2F1, cdc2, and D, and B cyclins in developing spinal cord , 1995, Neuroscience Letters.

[121]  K. Helin,et al.  An Inverted Repeat Motif Stabilizes Binding of E2F and Enhances Transcription of the Dihydrofolate Reductase Gene (*) , 1995, The Journal of Biological Chemistry.

[122]  J. Horowitz,et al.  Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[123]  E. Lam,et al.  Proto-oncogenic properties of the DP family of proteins. , 1995, Oncogene.

[124]  M. Oren,et al.  p53-mediated apoptosis in HeLa cells can be overcome by excess pRB. , 1995, Oncogene.

[125]  P. Robbins,et al.  The Retinoblastoma Susceptibility Gene Product Represses Transcription When Directly Bound to the Promoter (*) , 1995, The Journal of Biological Chemistry.

[126]  Wanjin Hong,et al.  A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor , 1995, Nature.

[127]  D. Livingston,et al.  Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. , 1995, Genes & development.

[128]  J. Nevins,et al.  E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis , 1995, Journal of virology.

[129]  B. Schaffhausen,et al.  Multiple change in E2F function and regulation occur upon muscle differentiation , 1995, Molecular and cellular biology.

[130]  R. Weinberg,et al.  E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[131]  M. Walsh,et al.  E2F-1 and a Cyclin-like DNA Repair Enzyme, Uracil-DNA Glycosylase, Provide Evidence for an Autoregulatory Mechanism for Transcription (*) , 1995, The Journal of Biological Chemistry.

[132]  L. Taylor,et al.  Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product , 1995, Nature.

[133]  L. Donehower,et al.  Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. , 1995, Cancer research.

[134]  K. Koike,et al.  A direct role of transcription factor E2F in c-myc gene expression during granulocytic and macrophage-like differentiation of HL60 cells. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[135]  D. Livingston,et al.  Multiple members of the E2F transcription factor family are the products of oncogenes. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[136]  M. Israel,et al.  Inhibition of apoptosis by the retinoblastoma gene product. , 1995, The EMBO journal.

[137]  M. Kitagawa,et al.  Phosphorylation of E2F-1 by cyclin A-cdk2. , 1995, Oncogene.

[138]  J. Nevins,et al.  Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[139]  S. Arfin,et al.  The sequence of porcine protein NH2-terminal asparagine amidohydrolase. A new component of the N-end Rule pathway. , 1995, The Journal of biological chemistry.

[140]  A. Zantema,et al.  Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile. , 1995, Oncogene.

[141]  K. Helin,et al.  Phosphorylation of a specific cdk site in E2F-1 affects its electrophoretic mobility and promotes pRB-binding in vitro. , 1995, Oncogene.

[142]  F. C. Lucibello,et al.  Periodic cdc25C transcription is mediated by a novel cell cycle‐regulated repressor element (CDE). , 1995, The EMBO journal.

[143]  J. Nevins,et al.  The Rb-related p107 protein can suppress E2F function independently of binding to cyclin A/cdk2 , 1995, Molecular and cellular biology.

[144]  D. Trouche,et al.  Regulation of transcription by E2F1/DP1 , 1995, Journal of Cell Science.

[145]  W. Sellers,et al.  Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter , 1994, Molecular and cellular biology.

[146]  Yang Xh,et al.  Overexpression of the E2F-1 transcription factor gene mediates cell transformation. , 1995 .

[147]  M. Schwab,et al.  The mycN/max protein complex in neuroblastoma. Short review. , 1995, European journal of cancer.

[148]  E. Lam,et al.  Cell-cycle regulation of human B-myb transcription. , 1995, Gene.

[149]  A. Look,et al.  Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line. , 1995, Genomics.

[150]  J. Brody,et al.  Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. , 1995, Cellular & molecular biology research.

[151]  P. J. Welch,et al.  Disruption of retinoblastoma protein function by coexpression of its C pocket fragment. , 1995, Genes & development.

[152]  Y. Liu,et al.  Regulation of cyclin D1, DNA topoisomerase I, and proliferating cell nuclear antigen promoters during the cell cycle. , 1995, Gene Expression.

[153]  G. Evan,et al.  Apoptosis and the cell cycle. , 1995, Current opinion in cell biology.

[154]  J B Lian,et al.  Transcription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[155]  J. Nevins,et al.  Oncogenic capacity of the E2F1 gene. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[156]  Y. Fujiwara,et al.  Selective repression of growth-regulating cdk2, cyclin E and E2F1 genes in human cell senescence. , 1994, The Kobe journal of medical sciences.

[157]  W. Lee,et al.  Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis , 1994, Molecular and cellular biology.

[158]  D. Lowy,et al.  Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins , 1994, Molecular and cellular biology.

[159]  C. Peng,et al.  Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation , 1994, Molecular and cellular biology.

[160]  J. Lawrence,et al.  E2F-4, a new member of the E2F transcription factor family, interacts with p107. , 1994, Genes & development.

[161]  L. Zhu,et al.  E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. , 1994, Genes & development.

[162]  W. Kaelin,et al.  Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[163]  E. Ziff,et al.  Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochromocytoma cells. , 1994, Molecular Biology of the Cell.

[164]  G. Condorelli,et al.  p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. , 1994, Cancer research.

[165]  P. Hearing,et al.  Mutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1 , 1994, Journal of virology.

[166]  P. Marks,et al.  Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells , 1994, Molecular and cellular biology.

[167]  Y. Furukawa,et al.  The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells. , 1994, The Journal of biological chemistry.

[168]  Sushovan Guha,et al.  The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest , 1994, Cell.

[169]  E. Lam,et al.  Molecular characterization of Xenopus laevis DP proteins. , 1994, Molecular biology of the cell.

[170]  Nic Jones,et al.  Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein , 1994, Cell.

[171]  D. Stacey,et al.  An E2F dominant negative mutant blocks E1A induced cell cycle progression. , 1994, Oncogene.

[172]  A. Berns,et al.  Developmental rescue of an embryonic‐lethal mutation in the retinoblastoma gene in chimeric mice. , 1994, The EMBO journal.

[173]  A. Bradley,et al.  Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. , 1994, Genes & development.

[174]  Liang Zhu,et al.  Interaction of c‐Myc with the pRb‐related protein p107 results in inhibition of c‐Myc‐mediated transactivation. , 1994, The EMBO journal.

[175]  R. DePinho,et al.  p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens , 1994, Nature.

[176]  The flight of the pterosaur , 1994, Nature.

[177]  K. Helin,et al.  Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein , 1994, Journal of virology.

[178]  J. Swantek,et al.  An E2F binding sequence negatively regulates the response of the insulin-like growth factor 1 (IGF-I) promoter to simian virus 40T antigen and to serum. , 1994, Oncogene.

[179]  B. Dynlacht,et al.  Differential regulation of E2F transactivation by cyclin/cdk2 complexes. , 1994, Genes & development.

[180]  R. Weinberg,et al.  Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. , 1994, Genes & development.

[181]  E. Batsché,et al.  Transcriptional repression and activation in the same cell type of the human c-MYC promoter by the retinoblastoma gene protein: antagonisation of both effects by SV40 T antigen. , 1994, Oncogene.

[182]  H. Moses,et al.  Inhibition of cell growth by TGF beta 1 is associated with inhibition of B-myb and cyclin A in both BALB/MK and Mv1Lu cells. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[183]  T. Jacks,et al.  Cooperative tumorigenic effects of germline mutations in Rb and p53 , 1994, Nature Genetics.

[184]  Wilhelm Krek,et al.  Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase , 1994, Cell.

[185]  N. Dyson,et al.  DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[186]  S. Friend,et al.  E2F and its developmental regulation in Xenopus laevis , 1994, Molecular and cellular biology.

[187]  J. Nevins,et al.  Interacting domains of E2F1, DP1, and the adenovirus E4 protein , 1994, Journal of virology.

[188]  P. Farnham,et al.  Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. , 1994, Genes & development.

[189]  H. Lovec,et al.  E2F-dependent regulation of human MYC: trans-activation by cyclins D1 and A overrides tumour suppressor protein functions. , 1994, Oncogene.

[190]  R Girling,et al.  DP‐1: a cell cycle‐regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. , 1994, The EMBO journal.

[191]  W. Hong,et al.  Overexpression of E2F‐1 in rat embryo fibroblasts leads to neoplastic transformation. , 1994, The EMBO journal.

[192]  J. Nevins,et al.  Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. , 1994, Genes & development.

[193]  Goberdhan P Dimri,et al.  Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. , 1994, The Journal of biological chemistry.

[194]  Kathleen R. Cho,et al.  p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[195]  T. Dryja,et al.  A silencer element in the retinoblastoma tumor-suppressor gene. , 1994, Oncogene.

[196]  A. Iavarone,et al.  The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. , 1994, Genes & development.

[197]  L. Bonetta,et al.  Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein. , 1994, Oncogene.

[198]  K. Nasmyth,et al.  Cell cycle regulated transcription in yeast. , 1994, Current opinion in cell biology.

[199]  D. Albert,et al.  Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. , 1994, Genes & development.

[200]  H. Pan,et al.  Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. , 1994, Genes & development.

[201]  K. Alitalo,et al.  Repression of cyclin D1: a novel function of MYC. , 1994, Molecular and cellular biology.

[202]  E. Wintersberger,et al.  Different regulation of thymidine kinase during the cell cycle of normal versus DNA tumor virus-transformed cells. , 1994, The Journal of biological chemistry.

[203]  G. Demers,et al.  Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[204]  B. Gallie,et al.  Characterization of the human RB1 promoter and of elements involved in transcriptional regulation. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[205]  J. Bartek,et al.  DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1 , 1994, The Journal of cell biology.

[206]  A. Levine,et al.  p53 and E2F-1 cooperate to mediate apoptosis. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[207]  J. Bartek,et al.  Cyclin D1 expression is regulated by the retinoblastoma protein. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[208]  C. Dang,et al.  Binding and suppression of the Myc transcriptional activation domain by p107. , 1994, Science.

[209]  M. Pagano,et al.  Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation , 1994, Journal of virology.

[210]  D. Hall,et al.  Detailed analysis of the basic domain of the E2F1 transcription factor indicates that it is unique among bHLH proteins. , 1994, Oncogene.

[211]  A. Bradley,et al.  Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. , 1994, Oncogene.

[212]  M. Beato,et al.  Inducible regulatory elements in the human cyclin D1 promoter. , 1994, Oncogene.

[213]  A. Giordano,et al.  Correlation between E2F-1 requirement in the S phase and E2F-1 transactivation of cell cycle-related genes in human cells. , 1994, Cancer research.

[214]  H. Huber,et al.  Retinoblastoma protein reverses DNA bending by transcription factor E2F. , 1994, The Journal of biological chemistry.

[215]  J. Nevins,et al.  Functional properties of a Drosophila homolog of the E2F1 gene , 1994, Molecular and cellular biology.

[216]  P. Farnham,et al.  Cloning, chromosomal location, and characterization of mouse E2F1 , 1994, Molecular and cellular biology.

[217]  E. Wintersberger,et al.  Coordinated trans activation of DNA synthesis- and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein , 1994, Molecular and cellular biology.

[218]  E. Harlow,et al.  Identification of G1 kinase activity for cdk6, a novel cyclin D partner , 1994, Molecular and cellular biology.

[219]  K. Koike,et al.  Transcription from the P2 promoter of human protooncogene myc is suppressed by retinoic acid through an interaction between the E2F element and its binding proteins. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[220]  M. Roussel,et al.  Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1. , 1994, Oncogene.

[221]  P. Branton,et al.  Functional interactions within adenovirus E1A protein complexes. , 1994, Oncogene.

[222]  T. Crook,et al.  HPV16 E7 oncoprotein deregulates B‐myb expression: correlation with targeting of p107/E2F complexes. , 1994, The EMBO journal.

[223]  B. Schaffhausen,et al.  Retinoblastoma antioncogene is involved in the inhibition of myogenesis by polyomavirus large T antigen. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[224]  A. Jetten,et al.  Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon gamma. Antagonism by retinoic acid and transforming growth factor beta 1. , 1994, The Journal of biological chemistry.

[225]  K. Helin,et al.  G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. , 1994, The Journal of biological chemistry.

[226]  C. Cinti,et al.  Interleukin 1 alpha stimulates nuclear phospholipase C in human osteosarcoma SaOS-2 cells. , 1994, The Journal of biological chemistry.

[227]  R. Weinberg,et al.  Distinct sub‐populations of the retinoblastoma protein show a distinct pattern of phosphorylation. , 1994, The EMBO journal.

[228]  W. Lee,et al.  The transcription factor E2F-1 mediates the autoregulation of RB gene expression , 1994, Molecular and cellular biology.

[229]  D. Riley,et al.  The retinoblastoma protein: more than a tumor suppressor. , 1994, Annual review of cell biology.

[230]  R. Watson,et al.  The role of Myb proteins in normal and neoplastic cell proliferation. , 1994, Critical reviews in oncogenesis.

[231]  T. Sakai,et al.  Effect of tumor suppressors on cell cycle-regulatory genes: RB suppresses p34cdc2 expression and normal p53 suppresses cyclin A expression. , 1994, Experimental cell research.

[232]  D. Livingston,et al.  Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. , 1993, Science.

[233]  M. Ewen,et al.  Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1 , 1993, Journal of virology.

[234]  R. Weinberg,et al.  Cell cycle-specific association of E2F with the p130 E1A-binding protein. , 1993, Genes & development.

[235]  S. Reed,et al.  Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[236]  K. Helin,et al.  Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes , 1993, Molecular and cellular biology.

[237]  G. Hannon,et al.  Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. , 1993, Genes & development.

[238]  D. Heimbrook,et al.  Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F , 1993, Molecular and cellular biology.

[239]  M. Vidal,et al.  The retinoblastoma protein binds to a family of E2F transcription factors , 1993, Molecular and cellular biology.

[240]  A. Duncan,et al.  The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. , 1993, Genes & development.

[241]  A. Jetten,et al.  Regulation of proliferation-specific and differentiation-specific genes during senescence of human epidermal keratinocyte and mammary epithelial cells. , 1993, Biochemical and biophysical research communications.

[242]  T. Kouzarides,et al.  The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro. , 1993, Nucleic acids research.

[243]  J. Nevins,et al.  Identification of distinct roles for separate E1A domains in disruption of E2F complexes , 1993, Molecular and cellular biology.

[244]  L. Johnston,et al.  Functional synergy between DP‐1 and E2F‐1 in the cell cycle‐regulating transcription factor DRTF1/E2F. , 1993, The EMBO journal.

[245]  H. Nojima,et al.  Differential activation of cyclin and cyclin-dependent kinase genes by adenovirus E1A12S cDNA product. , 1993, Experimental cell research.

[246]  K. Helin,et al.  Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. , 1993, Genes & development.

[247]  K. Helin,et al.  Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein , 1993, Molecular and cellular biology.

[248]  J. Nevins,et al.  Expression of transcription factor E2F1 induces quiescent cells to enter S phase , 1993, Nature.

[249]  A. Giordano,et al.  Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. , 1993, Oncogene.

[250]  W. Kaelin,et al.  E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[251]  J. Fridovich-Keil,et al.  DNA sequences required for serum-responsive regulation of expression from the mouse thymidine kinase promoter. , 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[252]  H. van Dam,et al.  Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines. , 1993, Oncogene.

[253]  D. Livingston,et al.  Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F , 1993, Molecular and cellular biology.

[254]  E. Lam,et al.  An E2F‐binding site mediates cell‐cycle regulated repression of mouse B‐myb transcription. , 1993, The EMBO journal.

[255]  M. Ewen,et al.  Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. , 1993, Genes & development.

[256]  A. Arnold,et al.  PRAD1/lCyclin D1 proto‐oncogene: Genomic organization, 5′ dna sequence, and sequence of a tumor‐specific rearrangement breakpoint , 1993 .

[257]  S. Hiebert.  Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression , 1993, Molecular and cellular biology.

[258]  C. Y. Wang,et al.  Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. , 1993, Science.

[259]  David M. Livingston,et al.  Functional interactions of the retinoblastoma protein with mammalian D-type cyclins , 1993, Cell.

[260]  R. Weinberg,et al.  Physical interaction of the retinoblastoma protein with human D cyclins , 1993, Cell.

[261]  Bert Vogelstein,et al.  Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 , 1993, Nature.

[262]  P. Humphrey,et al.  Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[263]  D. Heimbrook,et al.  Transcription factor E2F binds DNA as a heterodimer. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[264]  R. Glazer,et al.  Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1. , 1993, The Journal of biological chemistry.

[265]  B. Gallie,et al.  Molecular cloning and characterization of the mouse RB1 promoter. , 1993, Oncogene.

[266]  D. Kalman,et al.  Domains of E1A that bind p105Rb, p130, and p300 are required to block nerve growth factor-induced neurite growth in PC12 cells. , 1993, Molecular biology of the cell.

[267]  K. Münger,et al.  The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein , 1993, Journal of virology.

[268]  N. L. La Thangue,et al.  Transcriptional repression by the Rb-related protein p107. , 1993, Molecular biology of the cell.

[269]  Y. Taya,et al.  Protein phosphorylation required for the formation of E2F complexes regulates N-myc transcription during differentiation of human embryonal carcinoma cells. , 1993, Oncogene.

[270]  A. Pichler,et al.  A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene , 1993, Journal of virology.

[271]  M. Ewen,et al.  Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. , 1993, Genes & development.

[272]  P. Farnham,et al.  A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter , 1993, Molecular and cellular biology.

[273]  N. L. La Thangue,et al.  A new component of the transcription factor DRTF1/E2F , 1993, Nature.

[274]  J. Nevins,et al.  Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. , 1993, The EMBO journal.

[275]  Andrew J. Bannister,et al.  The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[276]  Jay W. Schneider,et al.  Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation , 1993, Cell.

[277]  V. Garsky,et al.  Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein , 1993, Molecular and cellular biology.

[278]  D. Livingston,et al.  Specific enzymatic dephosphorylation of the retinoblastoma protein , 1993, Molecular and cellular biology.

[279]  Dulic,et al.  老化ヒト二倍体線維芽細胞におけるG1サイクリン調節の変化 不活性サイクリンE‐Cdk2及びサイクリンD1‐Cdk2複合体 , 1993 .

[280]  S. N. Agoff,et al.  Regulation of the human hsp70 promoter by p53. , 1993, Science.

[281]  M. Al-Ubaidi,et al.  Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter , 1992, The Journal of cell biology.

[282]  W. Lee,et al.  Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F , 1992, Molecular and cellular biology.

[283]  D. Templeton,et al.  Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding , 1992, Molecular and cellular biology.

[284]  B. Calabretta,et al.  Regulation of BALB/c 3T3 fibroblast proliferation by B-myb is accompanied by selective activation of cdc2 and cyclin D1 expression. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[285]  Steven K. Hanks,et al.  Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins , 1992, Cell.

[286]  E. Huang,et al.  E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection , 1992, Molecular and cellular biology.

[287]  S. Reed,et al.  Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. , 1992, Genes & development.

[288]  A. Berns,et al.  Requirement for a functional Rb-1 gene in murine development , 1992, Nature.

[289]  R. Weinberg,et al.  Effects of an Rb mutation in the mouse , 1992, Nature.

[290]  A. Bradley,et al.  Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis , 1992, Nature.

[291]  R. Weinberg,et al.  Regulation of retinoblastoma protein functions by ectopic expression of human cyclins , 1992, Cell.

[292]  J. Blanchard,et al.  In vivo footprints between the murine C‐MYC P1 and P2 promoters , 1992, Oncogene.

[293]  B. Gallie,et al.  Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene. , 1992, Molecular and cellular biology.

[294]  Peggy J. Farnham,et al.  Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties , 1992, Cell.

[295]  Marc Vidal,et al.  A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F , 1992, Cell.

[296]  Michael R. Green,et al.  Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2 , 1992, Nature.

[297]  S. Weintraub,et al.  Retinoblastoma protein switches the E2F site from positive to negative element , 1992, Nature.

[298]  P. Meltzer,et al.  Amplification of a gene encoding a p53-associated protein in human sarcomas , 1992, Nature.

[299]  Kim Nasmyth,et al.  A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast , 1992, Nature.

[300]  J. Shay,et al.  Complexes containing the retinoblastoma gene product recognize different DNA motifs related to the E2F binding site. , 1992, Oncogene.

[301]  J. Nevins,et al.  Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[302]  S. Dalton,et al.  Cell cycle regulation of the human cdc2 gene. , 1992, The EMBO journal.

[303]  A. Pardee,et al.  Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[304]  L. Donehower,et al.  Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours , 1992, Nature.

[305]  K. Moberg,et al.  Three distinct elements within the murine c-myc promoter are required for transcription. , 1992, Oncogene.

[306]  D. Livingston,et al.  The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[307]  M. Pagano,et al.  Association of cdk2 kinase with the transcription factor E2F during S phase. , 1992, Science.

[308]  J. Nevins,et al.  The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. , 1992, Genes & development.

[309]  M. Ewen,et al.  The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner , 1992, Cell.

[310]  J. Nevins,et al.  A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex , 1992, Cell.

[311]  L. Tsai,et al.  Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F , 1992, Nature.

[312]  M. Ewen,et al.  Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. , 1992, Science.

[313]  C. Anderson,et al.  The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. , 1991, The EMBO journal.

[314]  Y. Qian,et al.  The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle , 1991, Cell.

[315]  M. Ewen,et al.  Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein , 1991, Cell.

[316]  J. Shay,et al.  A role for both RB and p53 in the regulation of human cellular senescence. , 1991, Experimental cell research.

[317]  J. Nevins,et al.  Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. , 1991, Genes & development.

[318]  J. Nevins,et al.  Role of E2F transcription factor in E1A-mediated trans activation of cellular genes , 1991, Journal of virology.

[319]  J. Nevins,et al.  Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A , 1991, Cell.

[320]  R. Weinmann,et al.  The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F , 1991, Cell.

[321]  W. Kaelin,et al.  The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein , 1991, Cell.

[322]  Joseph R. Nevins,et al.  The E2F transcription factor is a cellular target for the RB protein , 1991, Cell.

[323]  N. L. Thangue,et al.  Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor , 1991, Nature.

[324]  H. Nasheuer,et al.  Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells , 1991, Molecular and cellular biology.

[325]  W. Lee,et al.  Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase. , 1991, The EMBO journal.

[326]  J. Nevins,et al.  Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation , 1990, Cell.

[327]  G. Stein,et al.  Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. , 1990, Science.

[328]  J. Nevins,et al.  A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. , 1990, The EMBO journal.

[329]  M. Ewen,et al.  Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product , 1990, Molecular and cellular biology.

[330]  P. Rigby,et al.  The embryonal carcinoma stem cell Ela-like activity involves a differentiation-regulated transcription factor. , 1990, Nucleic acids research.

[331]  C. Kedinger,et al.  EIa-mediated transactivation of the adenovirus EIIa early promoter is restricted in undifferentiated F9 cells. , 1990, Oncogene.

[332]  N. Dyson,et al.  The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. , 1990, The EMBO journal.

[333]  D. Livingston,et al.  Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[334]  Daniel M. Albert,et al.  Retinoblastoma in transgenic mice , 1990, Nature.

[335]  D. Livingston,et al.  The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T , 1990, Cell.

[336]  K. Münger,et al.  Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. , 1989, The EMBO journal.

[337]  A. Pardee.  G1 events and regulation of cell proliferation. , 1989, Science.

[338]  J. Azizkhan,et al.  Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo , 1989, Molecular and cellular biology.

[339]  C. Kedinger,et al.  Cooperative binding of two E2F molecules to an Ela‐responsive promoter is triggered by the adenovirus Ela, but not by a cellular Ela‐like activity. , 1989, The EMBO journal.

[340]  Phang-lang Chen,et al.  Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation , 1989, Cell.

[341]  David M. Livingston,et al.  The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element , 1989, Cell.

[342]  E. Harlow,et al.  The retinoblastoma protein is phosphorylated during specific phases of the cell cycle , 1989, Cell.

[343]  M Lipp,et al.  E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[344]  M Lipp,et al.  Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter. , 1989, Genes & development.

[345]  P. Branton,et al.  Binding of the Rb1 protein to E1A products is required for adenovirus transformation. , 1989, Oncogene.

[346]  K. Münger,et al.  The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. , 1989, Science.

[347]  P. L. Chen,et al.  Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. , 1988, Science.

[348]  Wen-Hwa Lee,et al.  SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene , 1988, Cell.

[349]  Stephen H. Friend,et al.  Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product , 1988, Nature.

[350]  Wen-Hwa Lee,et al.  The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity , 1987, Nature.

[351]  J. Nevins,et al.  Promoter interaction of the E1A‐inducible factor E2F and its potential role in the formation of a multi‐component complex. , 1987, The EMBO journal.

[352]  P. Rigby,et al.  An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells , 1987, Cell.

[353]  J. Nevins,et al.  Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[354]  J. Nevins,et al.  Developmental control of a promoter-specific factor that is also regulated by the E1A gene product , 1987, Cell.

[355]  Stephen H. Friend,et al.  A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma , 1986, Nature.

[356]  B R Franza,et al.  Association of adenovirus early-region 1A proteins with cellular polypeptides , 1986, Molecular and cellular biology.

[357]  P. Branton,et al.  Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides. , 1985, Virology.

[358]  Raymond L. White,et al.  Homozygosity of chromosome 13 in retinoblastoma. , 1984, The New England journal of medicine.

[359]  T. P. Dryja,et al.  Expression of recessive alleles by chromosomal mechanisms in retinoblastoma , 1983, Nature.