Airway hyperresponsiveness is dissociated from airway wall structural remodeling.

[1]  I. Pavord,et al.  Increased sputum and bronchial biopsy IL-13 expression in severe asthma. , 2008, The Journal of allergy and clinical immunology.

[2]  J. Vernejoux,et al.  Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma , 2007, The Journal of experimental medicine.

[3]  C. Brightling,et al.  Inflammatory cell microlocalisation and airway dysfunction: cause and effect? , 2007, European Respiratory Journal.

[4]  I. Pavord,et al.  Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis. , 2007, The Journal of allergy and clinical immunology.

[5]  I. Pavord,et al.  Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma , 2007, Thorax.

[6]  C. Brightling.  Chronic cough due to nonasthmatic eosinophilic bronchitis: ACCP evidence-based clinical practice guidelines. , 2006, Chest.

[7]  I. Pavord,et al.  Expression of CXCR6 and its ligand CXCL16 in the lung in health and disease , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[8]  P. Sterk,et al.  Bronchial CD8 cell infiltrate and lung function decline in asthma. , 2005, American journal of respiratory and critical care medicine.

[9]  I. Pavord,et al.  IL-4-expressing bronchoalveolar T cells from asthmatic and healthy subjects preferentially express CCR 3 and CCR 4. , 2005, The Journal of allergy and clinical immunology.

[10]  C. Lemière,et al.  Differences in airway remodeling between subjects with severe and moderate asthma. , 2005, The Journal of allergy and clinical immunology.

[11]  S. Fukuhara,et al.  Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma , 2005, Thorax.

[12]  S. Orkin,et al.  A Critical Role for Eosinophils in Allergic Airways Remodeling , 2004, Science.

[13]  Choon-Sik Park,et al.  Development of chronic airway obstruction in patients with eosinophilic bronchitis: a prospective follow-up study. , 2004, Chest.

[14]  P. Woodruff,et al.  Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. , 2004, American journal of respiratory and critical care medicine.

[15]  S. Kawakami,et al.  Evaluation of airway wall thickness and air trapping by HRCT in asymptomatic asthma , 2003, European Respiratory Journal.

[16]  M. Mishima,et al.  Relationship of airway wall thickness to airway sensitivity and airway reactivity in asthma. , 2003, American journal of respiratory and critical care medicine.

[17]  I. Pavord,et al.  Comparison of airway immunopathology of eosinophilic bronchitis and asthma , 2003, Thorax.

[18]  M. Aubier,et al.  Airway structural alterations selectively associated with severe asthma. , 2003, American journal of respiratory and critical care medicine.

[19]  T. Shimoda,et al.  Bronchial hyperresponsiveness and airway inflammation in adolescents with asymptomatic childhood asthma , 2003, Allergy.

[20]  G. P. Herbison,et al.  Outcome in adulthood of asymptomatic airway hyperresponsiveness in childhood: A longitudinal population study , 2002, Pediatric pulmonology.

[21]  I. Pavord,et al.  Mast-cell infiltration of airway smooth muscle in asthma. , 2002, The New England journal of medicine.

[22]  D. Johns,et al.  Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma , 2002, Thorax.

[23]  Q. Hamid,et al.  Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma. , 2001, The Journal of allergy and clinical immunology.

[24]  H Itoh,et al.  Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices. , 2000, American journal of respiratory and critical care medicine.

[25]  Brightling,et al.  Eosinophilic bronchitis − what is it and why is it important? , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[26]  S. Spector,et al.  Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. , 2000, American journal of respiratory and critical care medicine.

[27]  S. Wenzel,et al.  Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. , 1999, American journal of respiratory and critical care medicine.

[28]  A J Wardlaw,et al.  Eosinophilic bronchitis is an important cause of chronic cough. , 1999, American journal of respiratory and critical care medicine.

[29]  S. Wenzel,et al.  Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease. , 1998, American journal of respiratory and critical care medicine.

[30]  P. Jeffery,et al.  Variation in the measurements of basement membrane thickness and inflammatory cell number in bronchial biopsies. , 1998, The European respiratory journal.

[31]  L. Boulet,et al.  Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine. , 1997, Chest.

[32]  I. Pavord,et al.  The use of induced sputum to investigate airway inflammation. , 1997, Thorax.

[33]  A. Foresi,et al.  Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma. , 1996, American journal of respiratory and critical care medicine.

[34]  L. Boulet,et al.  Airway responsiveness and bronchial-wall thickness in asthma with or without fixed airflow obstruction. , 1995, American journal of respiratory and critical care medicine.

[35]  P. Howarth,et al.  Immunohistochemistry on resin sections: a comparison of resin embedding techniques for small mucosal biopsies. , 1993, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

[36]  T. Fukuda,et al.  Airway hyperresponsiveness, increased intracellular spaces of bronchial epithelium, and increased infiltration of eosinophils and lymphocytes in bronchial mucosa in asthma. , 1992, The American review of respiratory disease.

[37]  P. Richman,et al.  Morphological integrity of the bronchial epithelium in mild asthma. , 1990, Thorax.

[38]  A. Wardlaw,et al.  Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity. , 1989, The American review of respiratory disease.

[39]  H J Gundersen,et al.  The efficiency of systematic sampling in stereology and its prediction * , 1987, Journal of microscopy.