论文信息 - Analysis of Signal Transduction Networks in Michaelis-Menten Equations and S-Systems

Analysis of Signal Transduction Networks in Michaelis-Menten Equations and S-Systems

Signal transduction networks of biological systems are highly complicated. How to mathematically describe a signal transduction network by systematic approaches so as to further exploit appropriate control strategies is becoming attractive to engineers. In this paper, a mathematical model of signal transduction networks with a simplified structure is proposed and related analyses are performed. Keywords—biological system, S-system, sensitivity, signal transduction network

[1] Properties of the Michaelis–Menten mechanism in phase space , 2006, math/0611119.

[2] M. Savageau,et al. Parameter Sensitivity as a Criterion for Evaluating and Comparing the Performance of Biochemical Systems , 1971, Nature.

[3] S. Hardy. A functional representation of the simulation data of biochemical models based on molecular activity , 2008 .

[4] Eberhard O. Voit,et al. Kinetic modeling using S-systems and lin-log approaches , 2007 .

[5] N. Rashevsky,et al. Mathematical biology , 1961, Connecticut medicine.

[6] Bor-Sen Chen,et al. A new measure of the robustness of biochemical networks , 2005, Bioinform..

[7] A Sorribas,et al. A comparison of variant theories of intact biochemical systems. I. Enzyme-enzyme interactions and biochemical systems theory. , 1989, Mathematical biosciences.

[8] K. F. Tipton,et al. Biochemical systems analysis: A study of function and design in molecular biology , 1978 .