Preparation and characterization of hexanoyl chitosan/polylactide blend films

In the present contribution, blend films of hexanoyl chitosan (H-chitosan) and polylactide (PLA) were prepared by the solution-casting technique from the corresponding blend solutions in chloroform. Fourier-transformed infrared spectroscopy results indicated no significant interaction between H-chitosan and PLA molecules. The thermal degradation behavior of the as-prepared blend films was found to be intermediate to those of the pure components. Only the blend film having the H-chitosan content of 20 wt% exhibited the degradation temperature greater than those of the pure components. All of the blend films exhibited one composition-dependent glass transition temperature, indicating partial miscibility between H-chitosan and PLA molecules in the bulk amorphous phase. The apparent degree of crystallinity of the PLA component in the blends was found to decrease monotonically with increasing H-chitosan content. Both the tensile strength at break and the Young's modulus of the blend films were found to decrease from that of the pure PLA to that of the pure H-chitosan with increasing H-chitosan content.

[1]  G. Boering,et al.  Biocompatibility of intraosseously implanted predegraded poly(lactide): an animal study , 1996 .

[2]  Claudio Migliaresi,et al.  Biodegradable fibres of poly(L-lactic acid) produced by melt spinning , 1997 .

[3]  D. Kaplan,et al.  Chitosan Film Acylation and Effects on Biodegradability , 1996 .

[4]  D. Cohn,et al.  Biodegradable PEO/PLA block copolymers. , 1988, Journal of biomedical materials research.

[5]  P. Supaphol.  Crystallization and melting behavior in syndiotactic polypropylene: Origin of multiple melting phenomenon , 2001 .

[6]  T. Iijima,et al.  Permeation of solutes through chemically modified chitosan membranes , 1995 .

[7]  S. Hirano,et al.  The blood compatibility of chitosan and N-acylchitosans. , 1985, Journal of biomedical materials research.

[8]  Michel Vert,et al.  Effects of morphology, conformation and configuration on the IR and Raman spectra of various poly(lactic acid)s , 1998 .

[9]  Y. Ohe,et al.  Selective N-acylation of chitosan. , 1976, Carbohydrate research.

[10]  M. N. R. Kumar.  A review of chitin and chitosan applications , 2000 .

[11]  P. Supaphol,et al.  Multiple melting behavior in isothermally crystallized poly(trimethylene terephthalate) , 2004 .

[12]  K. Wiener,et al.  Biologisch abbaubare polymere. 1. Mitt. Viskositäts‐molmassen‐beziehung für poly‐d,l‐lactid und poly(glycolid(50)‐co‐lactid(50)) , 1990 .

[13]  S. Nishimura,et al.  Chemospecific manipulations of a rigid polysaccharide: syntheses of novel chitosan derivatives with excellent solubility in common organic solvents by regioselective chemical modifications , 1991 .

[14]  G. Roberts,et al.  Reactions of chitosan: 2. Preparation and reactivity of N-acyl derivatives of chitosan☆ , 1981 .

[15]  H. Yamane,et al.  Characterization of chemical and solid state structures of acylated chitosans , 2000 .

[16]  W C de Bruijn,et al.  In vivo degradation and biocompatibility study of in vitro pre-degraded as-polymerized polyactide particles. , 1995, Biomaterials.

[17]  W. Park,et al.  Blood compatibility and biodegradability of partially N-acylated chitosan derivatives. , 1995, Biomaterials.

[18]  L. Hall,et al.  Some chemical and analytical aspects of polysaccharide modifications. III. Formation of branched-chain, soluble chitosan derivatives , 1984 .

[19]  Moon Suk Kim,et al.  Local drug delivery system using biodegradable polymers , 2003 .