Cognitive impairment and dementia in basal ganglia disorders

We present an update focusing on research from the past 2 years on cognitive impairment and dementia in basal ganglia disorders, including Huntington’s disease, progressive supranuclear palsy, Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies. In addition to the many recent papers that aim to refine descriptions of the cognitive phenotypes in the basal ganglia disorders, the current literature addresses the use of cognitive assessment in differential diagnosis of clinically overlapping disorders, the effects of surgical and pharmacologic treatments on cognitive functions, and the relationship between cognitive impairment and functional disability. We also discuss opportunities for enhancing the understanding of cognition in basal ganglia disorders through the use of improved study design and assessment strategies.

[1]  A Weindl,et al.  Neural correlates associated with impaired disgust processing in pre-symptomatic Huntington's disease. , 2004, Brain : a journal of neurology.

[2]  J. Hodges,et al.  Semantic memory is impaired in both dementia with Lewy bodies and dementia of Alzheimer's type: a comparative neuropsychological study and literature review , 2001, Journal of neurology, neurosurgery, and psychiatry.

[3]  J. Jankovic,et al.  Minocycline in Huntington's disease: A pilot study , 2004, Movement disorders : official journal of the Movement Disorder Society.

[4]  Jane S. Paulsen,et al.  Cognitive and Psychiatric Aspects of Huntington Disease Contribute to Functional Capacity , 2004, The Journal of nervous and mental disease.

[5]  M. Tovée,et al.  Pentagon drawing and neuropsychological performance in Dementia with Lewy Bodies, Alzheimer's disease, Parkinson's disease and Parkinson's disease with dementia , 2004, International journal of geriatric psychiatry.

[6]  J. Brandt,et al.  Onset and rate of striatal atrophy in preclinical Huntington disease , 2004, Neurology.

[7]  C. Lippa,et al.  Parkinsonian syndromes: Parkinson's disease dementia, dementia with Lewy bodies and progressive supranuclear palsy , 2004, Clinical Neuroscience Research.

[8]  Jane S. Paulsen,et al.  fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's Disease. , 2004, AJNR. American journal of neuroradiology.

[9]  L. Thal,et al.  Cognitive decline is faster in Lewy body variant than in Alzheimer's disease , 1998, Neurology.

[10]  D. Press.  Parkinson's disease dementia--a first step? , 2004, The New England journal of medicine.

[11]  P. Stanzione,et al.  Pergolide effect on cognitive functions in early-mild Parkinson’s disease , 2005, Journal of Neural Transmission.

[12]  M. Mehta,et al.  Cognitive and motor effects of dopaminergic medication withdrawal in Parkinson’s disease , 2004, Neuropsychologia.

[13]  R. Yee,et al.  Oculomotor control in asymptomatic and recently diagnosed individuals with the genetic marker for Huntington’s disease , 2003, Vision Research.

[14]  H. Katzen,et al.  Early cognitive changes and nondementing behavioral abnormalities in Parkinson's disease. , 2005, Advances in neurology.

[15]  I. McKeith,et al.  Temporal lobe atrophy on MRI in Parkinson disease with dementia , 2005, Neurology.

[16]  M. Brin,et al.  Effects of levodopa on cognitive functioning in moderate-to-severe Parkinson’s disease (MSPD) , 2004, Journal of Neural Transmission.

[17]  M. Brin,et al.  Neuropsychological functioning following bilateral subthalamic nucleus stimulation in Parkinson's disease. , 2004, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[18]  I. Katz,et al.  Effect of Psychiatric and Other Nonmotor Symptoms on Disability in Parkinson's Disease , 2004, Journal of the American Geriatrics Society.

[19]  S. Gilman,et al.  Differentiation of Alzheimer's disease from dementia with Lewy bodies utilizing positron emission tomography with [18F]fluorodeoxyglucose and neuropsychological testing , 2005, Experimental Neurology.

[20]  Sarah A. J. Reading,et al.  Functional MRI study of a serial reaction time task in Huntington's disease , 2004, Psychiatry Research: Neuroimaging.

[21]  C. Lyketsos,et al.  Randomized placebo‐controlled trial of donepezil in cognitive impairment in Parkinson's disease , 2004, International journal of geriatric psychiatry.

[22]  J. Borod,et al.  Cognitive and behavioral dysfunction in Parkinson’s disease: neurochemical and clinicopathological contributions , 2004, Journal of Neural Transmission.

[23]  Sarah A. J. Reading,et al.  Functional brain changes in presymptomatic Huntington's disease , 2004, Annals of neurology.

[24]  Günther Deuschl,et al.  Rivastigmine for dementia associated with Parkinson's disease. , 2004, The New England journal of medicine.

[25]  N. Lincoln,et al.  The effects of cognitive abilities on driving in people with Parkinson's disease , 2004, Disability and rehabilitation.

[26]  A. Benabid,et al.  Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson’s disease , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[27]  J Kassubek,et al.  Topography of cerebral atrophy in early Huntington’s disease: a voxel based morphometric MRI study , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[28]  M. Petrides,et al.  Neural Bases of Set-Shifting Deficits in Parkinson's Disease , 2004, The Journal of Neuroscience.

[29]  E B Larson,et al.  Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both , 2005, Neurology.

[30]  A. Lees,et al.  Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism. , 2005, Brain : a journal of neurology.

[31]  Tore Wentzel-Larsen,et al.  The rate of cognitive decline in Parkinson disease. , 2004, Archives of neurology.

[32]  J. Stout,et al.  Enhanced negative priming in Parkinson's disease. , 2002, Neuropsychology.

[33]  T. Robbins,et al.  The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study. , 2004, Brain : a journal of neurology.

[34]  A. Beuter,et al.  Lack of efficacy of a nicotine transdermal treatment on motor and cognitive deficits in Parkinson's disease , 2004, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[35]  I. McKeith,et al.  SIC Task Force appraisal of clinical diagnostic criteria for parkinsonian disorders , 2003, Movement disorders : official journal of the Movement Disorder Society.

[36]  W. C. Culbertson,et al.  Evidence for Impaired Encoding and Retrieval Memory Profiles in Parkinson Disease , 2004, Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.

[37]  H. Nagaraja,et al.  Donepezil in the treatment of dementia with lewy bodies. , 2004, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[38]  Y Ben-Shlomo,et al.  Clinical features and natural history of progressive supranuclear palsy , 2003, Neurology.

[39]  J. Stout,et al.  Reduced autonomic responsiveness to gambling task losses in Huntington's disease , 2004, Journal of the International Neuropsychological Society.

[40]  G K Wenning,et al.  Voxel based morphometry reveals a distinct pattern of frontal atrophy in progressive supranuclear palsy , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[41]  F. Carella,et al.  Neuropsychological follow up in patients with Parkinson's disease, striatonigral degeneration-type multisystem atrophy, and progressive supranuclear palsy , 2000, Journal of neurology, neurosurgery, and psychiatry.

[42]  G. Deuschl,et al.  Deep brain stimulation of the subthalamic nucleus improves cognitive flexibility but impairs response inhibition in Parkinson disease. , 2004, Archives of neurology.

[43]  J. Stout,et al.  Activation of conflicting responses in Parkinson's disease: evidence for degrading and facilitating effects on response time , 2005, Neuropsychologia.

[44]  R. van Reekum,et al.  The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies. , 2004, The Journal of neuropsychiatry and clinical neurosciences.

[45]  Akinori Nakamura,et al.  Cognitive- and motor-related regions in Parkinson's disease: FDOPA and FDG PET studies , 2004, NeuroImage.

[46]  A. O. Kellogg.  WILLIAM SHAKSPEARE AS A PHYSIOLOGIST, AND PSYCHOLOGIST , 1859 .

[47]  S Blond,et al.  Subthalamic nucleus stimulation induces deficits in decoding emotional facial expressions in Parkinson’s disease , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[48]  K. Kosaka,et al.  Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB) , 1996, Neurology.

[49]  D. Delis,et al.  A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease , 2004, Journal of the International Neuropsychological Society.

[50]  L. Defebvre,et al.  Cognitive and SPECT characteristics predict progression of Parkinson’s disease in newly diagnosed patients , 2004, Journal of Neurology.