3DMicroelectrodes forCoulometric Screeni-ng inMicrofakbricated Lab-on-a-Chip Devices

Thispaer presents resultsindicating thecomplete oxidation ofan analyte using a three-dimensional. large surface area microelectrode inaLab-on-a-Chip (LOC)device. Traditional photolithographic fabrication techniques were usedtoconstruct themicrochip prototype, with the exception ofthe3Delectrodes. Experiments were perfbrmed using a flow-iection scheme, where a 1 mM sample ofcatechol wasdirected towards thedetection reservoir.Oxidation voltage ataplanar upstream electrodeWasincreased from 0to1.2V in0. volt incrementsand was showntoredce the detection level ofthe sample a a downstream planar electrode (1.2 V). Oxidation voltgea theupstream 3Delctrode was changed imasimilar manner and wasshowntocompkte/y e/iminatedetection at adownstream planar electrode. These results indicate thecomplete removal of sample fromtieflowstrean, suggesting that3Dmicrofibricated electrodes could beusedin LOCdevice forcoulometric screening.