Genetic factors in child psychiatric disorders--I. A review of research strategies.

Until recently, most child psychiatrists, clinicians and researchers alike, paid scant attention to genetic factors. The majority, of course, accepted both the reality of genetic influences and the likelihood that they played some part in the psychiatric disorders that they treated

[1]  K. Kidd,et al.  Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish , 1989, Nature.

[2]  A. Bertelsen,et al.  Confirming unexpressed genotypes for schizophrenia. Risks in the offspring of Fischer's Danish identical and fraternal discordant twins. , 1989, Archives of general psychiatry.

[3]  J. Stevenson,et al.  A twin study of hyperactivity--II. The aetiological role of genes, family relationships and perinatal adversity. , 1989, Journal of child psychology and psychiatry, and allied disciplines.

[4]  H. J. Evans,et al.  No linkage of chromosome 5q11-q13 markers to schizophrenia in Scottish families , 1989, Nature.

[5]  K. Kendler.  Limitations of the ratio of concordance rates in monozygotic and dizygotic twins. , 1989, Archives of general psychiatry.

[6]  Martin Farrall,et al.  PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21 , 1989, The Lancet.

[7]  K. Kidd,et al.  Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree , 1988, Nature.

[8]  Hugh Gurling,et al.  Localization of a susceptibility locus for schizophrenia on chromosome 5 , 1988, Nature.

[9]  D. Fulker,et al.  Multiple regression analysis of twin data: etiology of deviant scores versus individual differences. , 1988, Acta geneticae medicae et gemellologiae.

[10]  S. M. Sumi,et al.  Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. , 1988, Science.

[11]  M. Gill,et al.  Linkage analysis of manic depression in an Irish family using H-ras 1 and INS DNA markers. , 1988, Journal of medical genetics.

[12]  J. Edwards.  The importance of genetic disease and the need for prevention. , 1988, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[13]  M. Ferguson-Smith.  Progress in the molecular cytogenetics of man. , 1988, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[14]  M. Mikkelsen.  The incidence of Down's syndrome and progress towards its reduction. , 1988, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[15]  M. Baron,et al.  Molecular Genetics and Human Disease Implications for Modern Psychiatric Research and Practice , 1988, British Journal of Psychiatry.

[16]  N L Segal,et al.  Personality similarity in twins reared apart and together. , 1988, Journal of personality and social psychology.

[17]  P. McGuffin,et al.  The Camberwell Collaborative Depression Study III. Depression and Adversity in the Relatives of Depressed Probands , 1988, British Journal of Psychiatry.

[18]  A. Reveley,et al.  Twin Birth and Adult Psychiatric Disorder , 1988, British Journal of Psychiatry.

[19]  P. Szatmari,et al.  Stoppage rules and genetic studies of autism , 1988, Journal of autism and developmental disorders.

[20]  K. Lange,et al.  The affected-pedigree-member method of linkage analysis. , 1988, American journal of human genetics.

[21]  J. Lanke,et al.  Mode of Inheritance as Indicated by One-sided and Two-sided Familial Taint: with an Application to Schizophrenia , 1987, British Journal of Psychiatry.

[22]  F. Earls.  On the familial transmission of child psychiatric disorder. , 1987, Journal of child psychology and psychiatry, and allied disciplines.

[23]  L. DeLisi,et al.  The role of molecular genetics in psychiatry , 1987, Biological Psychiatry.

[24]  C. Laird.  Proposed mechanism of inheritance and expression of the human fragile-X syndrome of mental retardation. , 1987, Genetics.

[25]  A. Beaudet,et al.  LINKAGE OF TUBEROUS SCLEROSIS TO ABO BLOOD GROUP , 1987, The Lancet.

[26]  J. Diamond,et al.  What maintains the frequencies of human genetic diseases? , 1987, Nature.

[27]  R. Murray,et al.  The Familial/Sporadic Distinction as a Strategy in Schizophrenia Research , 1987, British Journal of Psychiatry.

[28]  L. DeLisi,et al.  Unravelling the Relationship between Genetic and Environmental Risk Factors in Psychiatric Disorders , 1987, British Journal of Psychiatry.

[29]  M. Ferguson-Smith,et al.  Linkage of the tuberous sclerosis locus to a DNA polymorphism detected by v-abl. , 1987, Journal of medical genetics.

[30]  D. Hay,et al.  Early influences on the school social adjustment of twins. , 1987, Acta geneticae medicae et gemellologiae.

[31]  A. Tellegen,et al.  Recruitment bias in twin research: The rule of two-thirds reconsidered , 1987, Behavior genetics.

[32]  D. Hay,et al.  Birthweight differences, the transfusion syndrome and the cognitive development of monozygotic twins. , 1987, Acta geneticae medicae et gemellologiae.

[33]  M Williams,et al.  Speech and language development in preschool twins. , 1987, Acta geneticae medicae et gemellologiae.

[34]  K. Kidd,et al.  Family-Genetic Studies and Identification of Valid Diagnostic Categories in Adult and Child Psychiatry , 1987, British Journal of Psychiatry.

[35]  D. Loesch,et al.  Phenotypic variation in male-transmitted fragile X: genetic inferences. , 1987, American journal of medical genetics.

[36]  A. Farmer,et al.  Is There Really A Split in Schizophrenia? , 1987, British Journal of Psychiatry.

[37]  L. Greenswag,et al.  ADULTS WITH PRADER‐WILLI SYNDROME: A SURVEY OF 232 CASES , 1987 .

[38]  J. Dennis,et al.  PSYCHIATRIC DISORDER AMONG CHILDREN WITH TUBEROUS SCLEROSIS , 1987, Developmental medicine and child neurology.

[39]  S. Povey,et al.  EVIDENCE THAT THE GENE FOR TUBEROUS SCLEROSIS IS ON CHROMOSOME 9 , 1987, The Lancet.

[40]  N. Risch,et al.  Genetic linkage between X-chromosome markers and bipolar affective illness , 1987, Nature.

[41]  P Graham,et al.  A twin study of genetic influences on reading and spelling ability and disability. , 1987, Journal of child psychology and psychiatry, and allied disciplines.

[42]  S. Waisbren,et al.  Predictors of intelligence quotient and intelligence quotient change in persons treated for phenylketonuria early in life. , 1987, Pediatrics.

[43]  P. M. Guffin.  The new genetics and childhood psychiatric disorder. , 1987 .

[44]  A. Jensen,et al.  Why are children in the same family so different from one another? , 1987, Behavioral and Brain Sciences.

[45]  D. Pollen,et al.  The genetic defect causing familial Alzheimer's disease maps on chromosome 21. , 1987, Science.

[46]  E. Bryan.  The intrauterine hazards of twins. , 1986, Archives of disease in childhood.

[47]  K. Kidd,et al.  Family-genetic studies of psychiatric disorders. Developing technologies. , 1986, Archives of general psychiatry.

[48]  J. Leckman,et al.  The inheritance of Gilles de la Tourette's syndrome and associated behaviors. Evidence for autosomal dominant transmission. , 1986, The New England journal of medicine.

[49]  T. Webb,et al.  The frequency of the fragile X chromosome among schoolchildren in Coventry. , 1986, Journal of medical genetics.

[50]  E. Tuckerman,et al.  Replication status of fragile X(q27.3) in 13 female heterozygotes. , 1986, Journal of medical genetics.

[51]  G. Turner,et al.  Preventive screening for the fragile X syndrome. , 1986, The New England journal of medicine.

[52]  E. Gershon,et al.  Clinical methods in psychiatric genetics: II. The high risk approach , 1986, Acta psychiatrica Scandinavica.

[53]  E. Gershon,et al.  Clinical methods in psychiatric genetics: I. Robustness of genetic marker investigative strategies , 1986, Acta psychiatrica Scandinavica.

[54]  A J Jeffreys,et al.  DNA "fingerprints" and segregation analysis of multiple markers in human pedigrees. , 1986, American journal of human genetics.

[55]  A. Jeffreys,et al.  Cloning a selected fragment from a human DNA 'fingerprint': isolation of an extremely polymorphic minisatellite. , 1986, Nucleic acids research.

[56]  C Oliver,et al.  Down's Syndrome and Alzheimer's disease: a review , 1986, Psychological Medicine.

[57]  C. Moore,et al.  Fragile-X Mental Retardation Syndrome Transmitted Through Intellectually Normal Males: Implications for Genetic Counseling , 1986, Southern medical journal.

[58]  R. Murray,et al.  Genetic vulnerability to schizophrenia. , 1986, The Psychiatric clinics of North America.

[59]  L J Eaves,et al.  Models for the joint effect of genotype and environment on liability to psychiatric illness. , 1986, The American journal of psychiatry.

[60]  M. Butler,et al.  Clinical and cytogenetic survey of 39 individuals with Prader-Labhart-Willi syndrome. , 1986, American journal of medical genetics.

[61]  M. Seabright,et al.  Chromosome abnormalities in pupils attending ESN/M schools. , 1986, Archives of disease in childhood.

[62]  R. Glynn,et al.  Aging and generational effects on drinking behaviors in men: results from the normative aging study. , 1985, American journal of public health.

[63]  R. Lilford.  Chorion villus biopsy. , 1985, Clinics in obstetrics and gynaecology.

[64]  F. Schachter,et al.  Difficult Sibling, Easy Sibling: Temperament and the Within-Family Environment. , 1985 .

[65]  D. Fulker,et al.  Multiple regression analysis of twin data , 1985, Behavior genetics.

[66]  A C Heath,et al.  The resolution of cultural and biological inheritance: Informativeness of different relationships , 1985, Behavior genetics.

[67]  P. McGuffin,et al.  Can linkage and marker association resolve the genetic aetiology of psychiatric disorders? Review and argument , 1985, Psychological Medicine.

[68]  M. Pembrey,et al.  A premutation that generates a defect at crossing over explains the inheritance of fragile X mental retardation. , 1985, American journal of medical genetics.

[69]  A. Jeffreys,et al.  Individual-specific ‘fingerprints’ of human DNA , 1985, Nature.

[70]  S. Faraone,et al.  Quantitative models of the genetic transmission of schizophrenia. , 1985, Psychological bulletin.

[71]  G. Klerman,et al.  Birth-cohort trends in rates of major depressive disorder among relatives of patients with affective disorder. , 1985, Archives of general psychiatry.

[72]  J. Opitz,et al.  The effect of Mendelian disease on human health: a measurement. , 1985, American journal of medical genetics.

[73]  M. Rutter,et al.  Family and school influences on behavioural development. , 1985, Journal of child psychology and psychiatry, and allied disciplines.

[74]  A. Bertelsen.  Controversies and Consistencies in Psychiatric Genetics , 1985, Acta psychiatrica Scandinavica. Supplementum.

[75]  D. Offord,et al.  Pairs of Same-Sexed Siblings Discordant for Antisocial Behaviour , 1985, British Journal of Psychiatry.

[76]  Swee Lay Thein,et al.  Hypervariable ‘minisatellite’ regions in human DNA , 1985, Nature.

[77]  S. Walzer,et al.  X chromosome abnormalities and cognitive development: implications for understanding normal human development. , 1985, Journal of child psychology and psychiatry, and allied disciplines.

[78]  C. Disteche,et al.  Minor Xp21 chromosome deletion in a male associated with expression of Duchenne muscular dystrophy, chronic granulomatous disease, retinitis pigmentosa, and McLeod syndrome. , 1985, American journal of human genetics.

[79]  K. Merikangas,et al.  Genetic factors in the sex ratio of major depression , 1985, Psychological Medicine.

[80]  M. Rutter,et al.  Parental psychiatric disorder: effects on children , 1984, Psychological Medicine.

[81]  D. R. Owen,et al.  Heredity and familial environment in intelligence and educational level—a sibling study , 1984, Nature.

[82]  K. Kendler,et al.  An independent analysis of the Danish Adoption Study of Schizophrenia. VI. The relationship between psychiatric disorders as defined by DSM-III in the relatives and adoptees. , 1984, Archives of general psychiatry.

[83]  S. Torgersen.  Genetic and nosological aspects of schizotypal and borderline personality disorders. A twin study. , 1984, Archives of general psychiatry.

[84]  G. Mcclearn,et al.  Swedish early separated twins: identification and characterization. , 1984, Acta geneticae medicae et gemellologiae.

[85]  N. Morton,et al.  The marker (X) syndrome: a cytogenetic and genetic analysis , 1984, Annals of human genetics.

[86]  A. Young,et al.  A polymorphic DNA marker genetically linked to Huntington's disease , 1983, Nature.

[87]  S. Scarr,et al.  How people make their own environments: a theory of genotype greater than environment effects. , 1983, Child development.

[88]  I. Gottesman,et al.  Extracting meaning and direction from twin data. , 1983, Psychiatric developments.

[89]  S. Folstein,et al.  Conduct disorder and affective disorder among the offspring of patients with Huntington's Disease , 1983, Psychological Medicine.

[90]  K. Merikangas.  Assortative mating for psychiatric disorders and psychological traits. , 1982, Archives of general psychiatry.

[91]  S. Ratcliffe,et al.  Emotional disorder in XYY children: four case reports. , 1982, Journal of child psychology and psychiatry, and allied disciplines.

[92]  J. Lanke,et al.  Are we entering an age of melancholy? Depressive illnesses in a prospective epidemiological study over 25 years: the Lundby Study, Sweden , 1982, Psychological Medicine.

[93]  R. Cadoret.  Genotype–environment interaction in antisocial behaviour , 1982, Psychological Medicine.

[94]  M. Baron,et al.  Schizoaffective illness, schizophrenia and affective disorders: morbidity risk and genetic transmission , 1982, Acta Psychiatrica Scandinavica.

[95]  M. Baron.  Genetic models of schizophrenia , 1982, Acta Psychiatrica Scandinavica.

[96]  I. Uchida,et al.  Activity of the fragile X in heterozygous carriers. , 1982, American journal of human genetics.

[97]  T. Bouchard,et al.  Familial studies of intelligence: a review. , 1981, Science.

[98]  G. August,et al.  The Incidence of Cognitive Disabilities in the Siblings of Autistic Children , 1981, British Journal of Psychiatry.

[99]  M. Tsuang,et al.  Morbidity Risks of Schizophrenia and Affective Disorders among First Degree Relatives of Patients with Schizophrenia, Mania, Depression and Surgical Conditions , 1980, British Journal of Psychiatry.

[100]  Sandra Scarr,et al.  Twin method: Defense of a critical assumption , 1979, Behavior genetics.

[101]  J. Christian,et al.  Genetic variance in nonverbal intelligence: data from the kinships of identical twins. , 1979, Science.

[102]  K. Kidd,et al.  Recurrence risks in schizophrenia: Are they model dependent? , 1979, Behavior genetics.

[103]  K. Kidd,et al.  Research designs for the study of gene-environment interactions in psychiatric disorders. Report of a Foundations Fund for Research in Psychiatry Panel. , 1978, Archives of general psychiatry.

[104]  E. Gershon,et al.  Genetic strategies in biological psychiatry. , 1978, Archives of general psychiatry.

[105]  S. Folstein,et al.  Infantile autism: a genetic study of 21 twin pairs. , 1977, Journal of child psychology and psychiatry, and allied disciplines.

[106]  G. Sutherland.  Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium. , 1977, Science.

[107]  Lindon J. Eaves,et al.  Inferring the Causes of Human Variation , 1977 .

[108]  R Plomin,et al.  Genotype-environment interaction and correlation in the analysis of human behavior. , 1977, Psychological bulletin.

[109]  J. Ott,et al.  A computer program for linkage analysis of general human pedigrees. , 1976, American journal of human genetics.

[110]  I. Gottesman,et al.  The genetics, if any, of infantile autism and childhood schizophrenia , 1976, Journal of autism and childhood schizophrenia.

[111]  W. Nance,et al.  Genetic models for the analysis of data from the families of identical twins. , 1976, Genetics.

[112]  F. Vogel,et al.  Twin studies in medical genetics. , 1974, Acta geneticae medicae et gemellologiae.

[113]  G. Allen.  Scope and methodology of twin studies. , 1974, Acta geneticae medicae et gemellologiae.

[114]  N. Myrianthopoulos.  Congenital Malformations in Twins , 1974 .

[115]  N E Morton,et al.  Analysis of family resemblance. 3. Complex segregation of quantitative traits. , 1974, American journal of human genetics.

[116]  A. Cao,et al.  Sibship (21q21q) Translocation Down's Syndrome with Maternal Transmission , 1973, Journal of medical genetics.

[117]  K. Benirschke,et al.  Multiple pregnancy. 1. , 1973, The New England journal of medicine.

[118]  D. Safer,et al.  A familial factor in minimal brain dysfunction , 1973, Behavior genetics.

[119]  T. Reich,et al.  The use of multiple thresholds in determining the mode of transmission of semi‐continuous traits * , 1972, Annals of human genetics.

[120]  G. Corney,et al.  The effect of zygosity on the birth weight of twins , 1972, Annals of human genetics.

[121]  K. Castleman,et al.  Automatic karyotyping of quinacrine mustard stained human chromosomes. , 1971, Experimental cell research.

[122]  R. Elston,et al.  A general model for the genetic analysis of pedigree data. , 1971, Human heredity.

[123]  M. Fischer.  Psychoses in the Offspring of Schizophrenic Monozygotic Twins and their Normal Co-Twins , 1971, British Journal of Psychiatry.

[124]  D W Fulker,et al.  Comparison of the biometrical genetical, MAVA, and classical approaches to the analysis of human behavior. , 1970, Psychological bulletin.

[125]  A. Jensen,et al.  How Much Can We Boost IQ and Scholastic Achievement , 1969 .

[126]  L. Heston.  Psychiatric Disorders in Foster Home Reared Children of Schizophrenic Mothers , 1966, British Journal of Psychiatry.

[127]  D. Falconer.  The inheritance of liability to certain diseases, estimated from the incidence among relatives , 1965 .

[128]  C. Carter,et al.  Inheritance of congenital pyloric stenosis. , 1961, Journal of medical genetics.

[129]  J. A. Strong,et al.  The somatic chromosomes in mongolism. , 1959, Lancet.

[130]  Marie Skodak,et al.  A Final Follow-Up Study of One Hundred Adopted Children , 1949 .

[131]  L. Penrose.  THE DETECTION OF AUTOSOMAL LINKAGE IN DATA WHICH CONSIST OF PAIRS OF BROTHERS AND SISTERS OF UNSPECIFIED PARENTAGE , 1935 .

[132]  A. Bailey,et al.  Genetic factors in child psychiatric disorders--II. Empirical findings. , 1990, Journal of child psychology and psychiatry, and allied disciplines.

[133]  G. Hitman,et al.  Genes and diabetes mellitus. , 1989, British medical bulletin.

[134]  P. Bakker.  Autonomous languages of twins. , 1987, Acta geneticae medicae et gemellologiae.

[135]  H. Pétursson,et al.  Minisatellite mapping in manic depression. , 1987, Journal of psychiatric research.

[136]  I. Moilanen.  Dominance and submissiveness between twins. I. Perinatal and development aspects. , 1987, Acta geneticae medicae et gemellologiae.

[137]  E. Gershon,et al.  Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees , 1987, Nature.

[138]  R. Murray,et al.  Family history and birthweight in monozygotic twins concordant and discordant for psychosis. , 1987, Acta geneticae medicae et gemellologiae.

[139]  K. Kidd,et al.  Bipolar affective disorders linked to DNA markers on chromosome 11 , 1987, Nature.

[140]  H. Pétursson,et al.  Molecular genetic evidence for heterogeneity in manic depression , 1987, Nature.

[141]  H. Gurling,et al.  Candidate genes and favoured loci: strategies for molecular genetic research into schizophrenia, manic depression, autism, alcoholism and Alzheimer's disease. , 1986, Psychiatric developments.

[142]  K. Kendler,et al.  The familial sporadic classification: its power for the resolution of genetic and environmental etiologic factors. , 1986, Journal of psychiatric research.

[143]  H. Gurling.  Application of molecular biology to mental illness. Analysis of genomic DNA and brain mRNA. , 1985, Psychiatric developments.

[144]  B. Freeman,et al.  Gene mapping studies with the syndrome of autism , 1985, Behavior genetics.

[145]  S. Sandberg,et al.  Epidemiology of child psychiatric disorder: Methodological issues and some substantive findings , 1985, Child psychiatry and human development.

[146]  B. Freeman,et al.  Concordance for the syndrome of autism in 40 pairs of afflicted twins. , 1985, The American journal of psychiatry.

[147]  B. Suarez,et al.  Linkage analysis for psychiatric disorders. I. Basic concepts. , 1985, Psychiatric developments.

[148]  M. Prior,et al.  The high incidence of reading disability in twin boys and its implications for genetic analyses. , 1984, Acta geneticae medicae et gemellologiae.

[149]  R. Schiavi,et al.  Sex chromosome anomalies, hormones, and aggressivity. , 1984, Archives of general psychiatry.

[150]  K. Kidd,et al.  The detection of major loci by segregation and linkage analysis: A simulation study , 1984, Genetic epidemiology.

[151]  Thomas J. BouchardJr.  Twins Reared Together and Apart: What They Tell Us About Human Diversity , 1984 .

[152]  E. Sturt.  Analysis of linkage and association for diseases of genetic aetiology. , 1984, Statistics in medicine.

[153]  K. Kidd,et al.  Genetic strategies for the analysis of childhood behavioral traits. , 1982, Schizophrenia bulletin.

[154]  J. Bancroft,et al.  Klinefelter's syndrome in adolescence. , 1982, Archives of disease in childhood.

[155]  C. Chung,et al.  Segregation analysis of schizophrenia under a mixed genetic model. , 1980, Human heredity.

[156]  Hugh Lytton,et al.  Parent-Child Interaction: The Socialization Process Observed in Twin and Singleton Families , 1980 .

[157]  K. Kidd,et al.  The effects of variable age-of-onset and diagnostic criteria on the estimates of linkage: an example using manic-depressive illness and color blindness. , 1980, Social biology.

[158]  C. Carter,et al.  Genetics of common single malformations. , 1976, British medical bulletin.

[159]  J. Shields,et al.  A critical review of recent adoption, twin, and family studies of schizophrenia: behavioral genetics perspectives. , 1976, Schizophrenia bulletin.

[160]  N. Garmezy,et al.  Children at risk: the search for the antecedents of schizophrenia. Part I. Conceptual models and research methods. , 1974, Schizophrenia bulletin.

[161]  S. Kety,et al.  Crossfostering. A research strategy for clarifying the role of genetic and experiential factors in the etiology of schizophrenia. , 1974, Archives of General Psychiatry.

[162]  D. Jackson.  A Critique of the Literature on the Genetics of Schizophrenia. , 1960 .