A model of lymphocyte recirculation.

Abstract Dov Stekel, Claire Parker and Martin Nowak present a mathematical model of T-cell recirculation between blood, spleen and the lymphatic system. Comparison with classical experiments on lymphocyte recirculation and localization demonstrates that simple kinetics are sufficient to explain lymphocyte homeostasis between these organs, and that T-cell counts in blood are highly sensitive to changes in the recirculation parameters.

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