Increased Expression of SPan-1 Antigen in Liver Metastases of Human Colorectal Carcinoma

大腸癌肝転移症例24例を対象として原発巣および肝転移巣でのSPan-1抗原およびCEAの発現を検討した.原発巣におけるSPan-1抗原,CEAの陽性率は,それぞれ87.5%,91.0%と高率であった.次に,原発巣および肝転移巣の組織発現の程度を比較検討したところ,SPan-1抗原は原発巣陽性例21例中10例の47.6%に肝転移巣における発現の増加を認め,総計学的に有意な差を認めた(p<0.02).一方,CEAについてみると,原発巣陽性例23例中,肝転移巣での発現増加が認められたのは21.7%(5/23例)であり,Sean-1.抗原の検討で認あられたような,肝転移巣における発現の増加は認めず,74,0%の症例は,原発巣と同程度の発現を示した.以上のことから,大腸癌においてSPan-1抗原の発現が癌転移に関与している可能性が示唆され,SPan-1抗原は大腸癌の肝転移因子として重要であると推測された.

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