Structural integrity of the corpus callosum predicts long‐term transfer of fluid intelligence‐related training gains in normal aging

Although cognitive training usually improves cognitive test performance, the capability to transfer these training gains into respective or functionally related cognitive domains varies significantly. Since most studies demonstrate rather limited transfer effects in older adults, aging might be an important factor in transfer capability differences. This study investigated the transfer capability of logical reasoning training gains to a measure of Fluid Intelligence (Gf) in relation to age, general intelligence, and brain structural integrity as measured by diffusion tensor imaging. In a group of 41 highly educated healthy elderly, 71% demonstrated successful transfer immediately after a 4‐week training session (i.e. short‐term transfer). In a subgroup of 22% of subjects transfer maintained over a 3‐month follow‐up period (i.e. long‐term transfer). While short‐term transfer was not related to structural integrity, long‐term transfer was associated with increased structural integrity in corpus and genu of the corpus callosum. Since callosal structural integrity was also related to age (in the present and foregoing studies), previously observed associations between age and transfer might be moderated by the structural integrity. Surprisingly, age was not directly associated with transfer in this study which could be explained by the multi‐dependency of the structural integrity (modulating factors beside age, e.g. genetics). In this highly educated sample, general intelligence was not related to transfer suggesting that high intelligence is not sufficient for transfer in normal aging. Further studies are needed to reveal the interaction of transfer, age, and structural integrity and delineate mechanisms of age‐dependent transfer capabilities. Hum Brain Mapp 35:309–318, 2014. © 2012 Wiley Periodicals, Inc.

[1]  R. Kraft,et al.  Relating imaging indices of white matter integrity and volume in healthy older adults. , 2008, Cerebral cortex.

[2]  Anthony Randal McIntosh,et al.  Age-related Changes in Brain Activity across the Adult Lifespan , 2006, Journal of Cognitive Neuroscience.

[3]  J. Colquitt,et al.  Toward an integrative theory of training motivation: a meta-analytic path analysis of 20 years of research. , 2000, The Journal of applied psychology.

[4]  Naftali Raz,et al.  Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk , 2009, Brain Research.

[5]  G. Juckel,et al.  Test-performance after cognitive training in persons at risk mental state of schizophrenia and patients with schizophrenia , 2011, Psychiatry Research.

[6]  P. Basser,et al.  Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. , 1996, Journal of magnetic resonance. Series B.

[7]  George W Rebok,et al.  Effects of cognitive training interventions with older adults: a randomized controlled trial. , 2002, JAMA.

[8]  A. Baddeley.  Working memory: looking back and looking forward , 2003, Nature Reviews Neuroscience.

[9]  Arthur W. Toga,et al.  Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template , 2008, NeuroImage.

[10]  John R. Anderson,et al.  The Transfer of Cognitive Skill , 1989 .

[11]  Karlene K. Ball,et al.  Transfer of a Speed of Processing Intervention to Near and Far Cognitive Functions , 2002, Gerontology.

[12]  Paul B. Baltes,et al.  Plasticity and Enhancement of Intellectual Functioning in Old Age , 1982 .

[13]  Timothy T. Baldwin,et al.  Transfer of Training: A Meta-Analytic Review , 2010 .

[14]  Jessica A. Grahn,et al.  Putting brain training to the test , 2010, Nature.

[15]  Scott M. Hofer,et al.  Handbook of cognitive aging : interdisciplinary perspectives , 2008 .

[16]  J. Kray,et al.  How useful is executive control training? Age differences in near and far transfer of task-switching training. , 2009, Developmental science.

[17]  Viktor Müller,et al.  Memory plasticity across the life span: uncovering children's latent potential. , 2007, Developmental psychology.

[18]  Susanne M. Jaeggi,et al.  Improving fluid intelligence with training on working memory: a meta-analysis , 2008, Psychonomic Bulletin & Review.

[19]  Steven N. Austad,et al.  Handbook of the Biology of Aging , 2012 .

[20]  Daniel Rueckert,et al.  Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data , 2006, NeuroImage.

[21]  L. Bäckman,et al.  Remembering Numbers in Old Age: Mnemonic Training Versus Self-Generated Strategy Training , 2003 .

[22]  Daniel Rueckert,et al.  Nonrigid registration using free-form deformations: application to breast MR images , 1999, IEEE Transactions on Medical Imaging.

[23]  F. Craik,et al.  The handbook of aging and cognition , 1992 .

[24]  M. B. Jurado,et al.  The Elusive Nature of Executive Functions: A Review of our Current Understanding , 2007, Neuropsychology Review.

[25]  S. Mori,et al.  Principles of Diffusion Tensor Imaging and Its Applications to Basic Neuroscience Research , 2006, Neuron.

[26]  Jun Li,et al.  Brain Anatomical Network and Intelligence , 2009, NeuroImage.

[27]  Lars Nyberg,et al.  Plasticity of executive functioning in young and older adults: immediate training gains, transfer, and long-term maintenance. , 2008, Psychology and aging.

[28]  G. Hynd,et al.  The Role of the Corpus Callosum in Interhemispheric Transfer of Information: Excitation or Inhibition? , 2005, Neuropsychology Review.

[29]  Stephen M Smith,et al.  Fast robust automated brain extraction , 2002, Human brain mapping.

[30]  J. Jonides,et al.  Storage and executive processes in the frontal lobes. , 1999, Science.

[31]  Klaus P. Ebmeier,et al.  The APOE ɛ4 allele modulates brain white matter integrity in healthy adults , 2011, Molecular Psychiatry.

[32]  P. Baltes,et al.  Basic forms of cognitive plasticity extended into the oldest-old: retest learning, age, and cognitive functioning. , 2006, Psychology and aging.

[33]  Lars Nyberg,et al.  Cognitive and neural plasticity in aging: General and task-specific limitations , 2006, Neuroscience & Biobehavioral Reviews.

[34]  Karlene K. Ball,et al.  INCREASING MOBILITY AND REDUCING ACCIDENTS OF OLDER DRIVERS. IN: MOBILITY AND TRANSPORTATION IN THE ELDERLY , 2000 .

[35]  K. Anders Ericsson,et al.  Working Memory and Expert Performance , 1998 .

[36]  D. Dagenbach,et al.  Recollection Training and Transfer Effects in Older Adults: Successful Use of a Repetition-Lag Procedure , 2005, Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition.

[37]  Ingrid R Olson,et al.  Working memory training and transfer in older adults. , 2011, Psychology and aging.

[38]  Erica L. Wohldmann,et al.  Specificity effects in training and transfer of speeded responses. , 2006, Journal of experimental psychology. Learning, memory, and cognition.

[39]  Arthur F Kramer,et al.  Testing the limits of cognitive plasticity in older adults: application to attentional control. , 2006, Acta psychologica.

[40]  C. Chabris,et al.  Neural mechanisms of general fluid intelligence , 2003, Nature Neuroscience.

[41]  Erika Borella,et al.  Working memory training in older adults: evidence of transfer and maintenance effects. , 2010, Psychology and aging.

[42]  Susan M. Barnett,et al.  When and where do we apply what we learn? A taxonomy for far transfer. , 2002, Psychological bulletin.

[43]  Denise C. Park,et al.  Human neuroscience and the aging mind: a new look at old problems. , 2010, The journals of gerontology. Series B, Psychological sciences and social sciences.

[44]  J Trabka,et al.  [Role of the corpus callosum]. , 1968, Acta physiologica Polonica.

[45]  R. Cattell,et al.  Refinement and test of the theory of fluid and crystallized general intelligences. , 1966, Journal of educational psychology.

[46]  Lars Bäckman,et al.  Transfer of Learning After Updating Training Mediated by the Striatum , 2008, Science.

[47]  C. Beaulieu,et al.  The basis of anisotropic water diffusion in the nervous system – a technical review , 2002, NMR in biomedicine.

[48]  M. Carlson,et al.  Training and Maintaining Memory Abilities in Healthy Older Adults: Traditional and Novel Approaches. , 2007, The journals of gerontology. Series B, Psychological sciences and social sciences.

[49]  D. Pandya,et al.  Topography of commissural fibers of the prefrontal cortex in the rhesus monkey , 2004, Experimental Brain Research.

[50]  P. Stoeter,et al.  Diagnostic utility of different MRI and MR angiography measures in Fabry disease , 2009, Neurology.