Magnetic resonance imaging and magnetic resonance angiography in long term survivors of acute lymphoblastic leukemia treated with cranial irradiation

Background. Successful treatment of acute lymphoblastic leukemia (ALL) has resulted in an increasing number of patients whose disease is cured. This treatment includes cranial irradiation as prophylaxis against central nervous system relapse. The late effects of irradiation are well documented, but their incidence is unknown. The authors investigated the late effects of this treatment modality further by scanning 35 long term survivors of ALL who received cranial irradiation.

[1]  S. Sallan,et al.  Brain tumors after cranial irradiation for childhood acute lymphoblastic leukemia. A 13‐year experience from the Dana‐Farber cancer institute and the children's hospital , 1987, Cancer.

[2]  C. Pochedly.  Prevention of meningeal leukemia. Review of 20 years of research and current recommendations. , 1990, Hematology/oncology clinics of North America.

[3]  R. Aur,et al.  Central nervous system therapy and combination chemotherapy of childhood lymphocytic leukemia. , 1971, Blood.

[4]  W P Dillon,et al.  Radiation injury of the brain. , 1991, AJNR. American journal of neuroradiology.

[5]  S. Pittaluga,et al.  Intracranial meningiomas following low-dose irradiation to the head. , 1983, Journal of neurosurgery.

[6]  N. Foreman,et al.  Childhood malignancies in the south-west region of England, 1976-1985. , 1994, Medical and pediatric oncology.

[7]  L. Meacham,et al.  Childhood intracranial meningiomas after high‐dose irradiation , 1993, Cancer.

[8]  S. Hilal,et al.  Cerebrovasculopathy following irradiation in childhood , 1975, Neurology.

[9]  J. Conomy,et al.  Delayed cerebrovascular consequences of therapeutic radiation. A clinicopathologic study of a stroke associated with radiation‐related carotid arteriopathy , 1975, Cancer.

[10]  A. Elster,et al.  An analysis of the natural history of cavernous angiomas. , 1991, Journal of neurosurgery.

[11]  W. Montanera,et al.  Meningioma and occlusive vasculopathy: coexisting complications of past extracranial radiation. , 1985, Surgical neurology.

[12]  R. Aur,et al.  A comparative study of central nervous system irradiation and intensive chemotherapy early in remission of childhood acute lymphocytic leukemia , 1972, Cancer.

[13]  R. Laitt,et al.  Intracranial large vessel vasculopathy and anaplastic meningioma 19 years after cranial irradiation for acute lymphoblastic leukaemia. , 1995, Medical and pediatric oncology.

[14]  S. DeArmond,et al.  Radiation-induced large intracranial vessel occlusive vasculopathy. , 1980, AJR. American journal of roentgenology.

[15]  H. Handa,et al.  Occlusive arteriopathy and brain tumor. , 1978, Journal of neurosurgery.

[16]  G. Rutherfoord,et al.  Malignant glioma following radiotherapy for unrelated primary tumors , 1986, Cancer.

[17]  F. Skultety,et al.  Radiation‐induced neoplasms of the brain , 1987, Cancer.

[18]  Ja Wilson,et al.  Principles and practice of screening for disease , 1968 .

[19]  R. Mitnick,et al.  Radiation-induced meningiomas: experience at the Mount Sinai Hospital and review of the literature. , 1991, Journal of neurosurgery.

[20]  A. Kingma,et al.  Magnetic resonance imaging of the brain and neuropsychological evaluation in children treated for acute lymphoblastic leukemia at a young age. , 1993, The American journal of pediatric hematology/oncology.

[21]  L. Jannoun,et al.  Neurotoxicity in lymphoblastic leukaemia: comparison of oral and intramuscular methotrexate and two doses of radiation. , 1990, Archives of disease in childhood.

[22]  W W Holland,et al.  Validation of screening procedures. , 1971, British medical bulletin.

[23]  E. Pääkkö,et al.  White matter changes in children treated for acute lymphoblastic leukemia , 1992, Cancer.

[24]  A. Evans,et al.  The increasing incidence of central nervous system leukemia in children. (Children's cancer study group a) , 1970, Cancer.