Role of p38 MAP kinase signaling pathways in storage and voiding dysfunction in mice with spinal cord injury

To investigate the role of p38 MAP kinase in lower urinary tract dysfunction in mice with spinal cord injury (SCI).

[1]  Takahiro Shimizu,et al.  The effect of neutralization of nerve growth factor (NGF) on bladder and urethral dysfunction in mice with spinal cord injury , 2018, Neurourology and urodynamics.

[2]  Takahiro Shimizu,et al.  Nerve growth factor‐dependent hyperexcitability of capsaicin‐sensitive bladder afferent neurones in mice with spinal cord injury , 2018, Experimental physiology.

[3]  A. Kanai,et al.  Morphological changes in different populations of bladder afferent neurons detected by herpes simplex virus (HSV) vectors with cell-type-specific promoters in mice with spinal cord injury , 2017, Neuroscience.

[4]  Takahiro Shimizu,et al.  The role of capsaicin-sensitive C-fiber afferent pathways in the control of micturition in spinal-intact and spinal cord-injured mice. , 2017, American journal of physiology. Renal physiology.

[5]  George M. Smith,et al.  Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury , 2017, International journal of molecular sciences.

[6]  Yong Ho Kim,et al.  Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord , 2016, Brain, Behavior, and Immunity.

[7]  Takahiro Shimizu,et al.  Characterization of bladder and external urethral activity in mice with or without spinal cord injury--a comparison study with rats. , 2016, American journal of physiology. Regulatory, integrative and comparative physiology.

[8]  Daishi Tian,et al.  Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury , 2012, Journal of Neuroinflammation.

[9]  N. Yoshimura,et al.  Plasticity in reflex pathways to the lower urinary tract following spinal cord injury , 2012, Experimental Neurology.

[10]  E. Feldman,et al.  p38 mediates mechanical allodynia in a mouse model of type 2 diabetes , 2010, Molecular pain.

[11]  A. Cuenda,et al.  p38 MAP-kinases pathway regulation, function and role in human diseases. , 2007, Biochimica et biophysica acta.

[12]  P. Ernfors,et al.  Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion , 2007, The Journal of comparative neurology.

[13]  W. D. de Groat,et al.  Bladder Overactivity and Hyperexcitability of Bladder Afferent Neurons after Intrathecal Delivery of Nerve Growth Factor in Rats , 2006, The Journal of Neuroscience.

[14]  William C. de Groat,et al.  Histological and Electrical Properties of Rat Dorsal Root Ganglion Neurons Innervating the Lower Urinary Tract , 2003, The Journal of Neuroscience.

[15]  Haruyasu Yamamoto,et al.  Continuous intrathecal infusion of SB203580, a selective inhibitor of p38 mitogen-activated protein kinase, reduces the damage of hind-limb function after thoracic spinal cord injury in rat , 2003, Neuroscience Research.

[16]  W. D. de Groat,et al.  Immunoneutralization of nerve growth factor in lumbosacral spinal cord reduces bladder hyperreflexia in spinal cord injured rats. , 2002, The Journal of urology.

[17]  C. Woolf,et al.  p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia , 2002, Neuron.

[18]  M. Vizzard,et al.  Up‐regulation of tyrosine kinase (Trka, Trkb) receptor expression and phosphorylation in lumbosacral dorsal root ganglia after chronic spinal cord (T8–T10) injury , 2002, The Journal of comparative neurology.

[19]  M. Vizzard.  Changes in Urinary Bladder Neurotrophic Factor mRNA and NGF Protein Following Urinary Bladder Dysfunction , 2000, Experimental Neurology.

[20]  W. C. Groat,et al.  Effects of spinal cord injury on neurofilament immunoreactivity and capsaicin sensitivity in rat dorsal root ganglion neurons innervating the urinary bladder , 1998, Neuroscience.

[21]  W. C. Groat,et al.  Effect of capsaicin on micturition and associated reflexes in chronic spinal rats , 1995, Brain Research.

[22]  D. Griffiths,et al.  Neural control of the lower urinary tract. , 2015, Comprehensive Physiology.

[23]  M. Vizzard.  Neurochemical plasticity and the role of neurotrophic factors in bladder reflex pathways after spinal cord injury. , 2006, Progress in brain research.

[24]  W. D. de Groat,et al.  Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats. , 2004, The Journal of urology.