Hot off the Press.

A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as pedrolide from Euphorbia pedroi.

[1]  Yu-huan Li,et al.  Illihenin A: An Antiviral Sesquiterpenoid with a Cage-like Tricyclo[6.2.2.01,5]dodecane Skeleton from Illicium henryi. , 2021, Journal of Organic Chemistry.

[2]  Ricardo J. Ferreira,et al.  Pedrolane, a Polycyclic Diterpene Scaffold Containing a Bicyclo[2.2.1]heptane System, from Euphorbia pedroi. , 2020, Organic Letters.

[3]  Kenji Watanabe,et al.  Biosynthesis of the Immunosuppressant (-)-FR901483. , 2020, Journal of the American Chemical Society.

[4]  W. Oh,et al.  Melicopteline A-E, Unusual Cyclopeptide Alkaloids with Antiviral Activity against Influenza A Virus from Melicope pteleifolia. , 2020, The Journal of organic chemistry.

[5]  H. Hashimoto,et al.  Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis. , 2020, Journal of the American Chemical Society.

[6]  Yun Li,et al.  (±)-Pabmaragramin, a scalemic meroterpenoid produced by Marasmius graminum via precursor-assisted biosynthesis , 2020 .

[7]  H. Hailes,et al.  Norcoclaurine Synthase-Mediated Stereoselective Synthesis of 1,1’-Disubstituted, Spiro- and Bis-Tetrahydroisoquinoline Alkaloids , 2020, ACS Catalysis.

[8]  Kechun Liu,et al.  Lemnardosinanes A-I: New Bioactive Sesquiterpenoids from Soft Coral Lemnalia sp. , 2020, Journal of Organic Chemistry.

[9]  B. Shen,et al.  PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine N-Acetyltransferases. , 2020, ACS chemical biology.

[10]  Afsar Khan,et al.  Penipyranicins A-C: Antibacterial Methylpyran Polyketides from a Hydrothermal Spring Sediment Penicillium sp. , 2020, Journal of Natural Products.

[11]  X. Hao,et al.  Quinolizidine Alkaloids with Antiviral and Insecticidal Activities from the Seeds of Sophora tonkinensis Gagnep. , 2020, Journal of agricultural and food chemistry.

[12]  Jeff H. Chang,et al.  Biosynthesis of the Nuclear Factor of Activated T Cells Inhibitor NFAT-133 in Streptomyces pactum. , 2020, ACS chemical biology.

[13]  Guangying Chen,et al.  Applanhydrides A and B, lanostane triterpenoids with unprecedented seven-membered cyclo-anhydride in ring C from Ganoderma applanatum , 2020 .

[14]  S. A. Alias,et al.  Structure Elucidation of the spiro-Polyketide Svalbardine B from the Arctic Fungal Endophyte Poaceicola sp. E1PB with Support from Extensive ESI-MSn Interpretation. , 2020, Journal of Natural Products.

[15]  A. Carroll,et al.  Citronamine A, an Antiplasmodial Isoquinoline Alkaloid from the Australian Marine Sponge Citronia astra. , 2020, Organic Letters.

[16]  Liyan Yu,et al.  Zelkovamycins B-E, Cyclic Octapeptides Containing Rare Amino Acid Residues from an Endophytic Kitasatospora sp. , 2020, Organic letters.

[17]  Jeroen S. Dickschat,et al.  Diterpene Biosynthesis in Catenulispora acidiphila: On the Mechanism of Catenul‐14‐en‐6‐ol Synthase , 2020, Angewandte Chemie.

[18]  Silvia Anselmi,et al.  A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent. , 2020, Organic & biomolecular chemistry.

[19]  W. Kroutil,et al.  C=C-Ene-Reductases Reduce the C=N Bond of Oximes , 2020, ACS catalysis.

[20]  Haibo Tan,et al.  Structural elucidation, total synthesis, and cytotoxic activity of effphenol A. , 2020, Organic & biomolecular chemistry.

[21]  I. Abe,et al.  Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis. , 2020, Organic letters.

[22]  R. Cox,et al.  Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari. , 2020, Organic & biomolecular chemistry.

[23]  Deeptak Verma,et al.  Enantioselective Enzymatic Reduction of Acrylic Acids. , 2020, Organic letters.

[24]  R. Cox,et al.  Uncovering biosynthetic relationships between antifungal nonadrides and octadrides† , 2020, Chemical science.

[25]  J. Kalinowski,et al.  Synthetic Biology Driven Biosynthesis of Unnatural Tropolone Sesquiterpenoids , 2020, Angewandte Chemie.

[26]  G. Challis,et al.  Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism , 2020, Angewandte Chemie.

[27]  Wei Tang,et al.  Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa. , 2020, Bioorganic chemistry.

[28]  Keunwan Park,et al.  Rhizolutin, a novel 7/10/6-tricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimer's disease. , 2020, Angewandte Chemie.

[29]  K. Houk,et al.  Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway. , 2020, ACS catalysis.

[30]  M. Kaltenpoth,et al.  Insect‐Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non‐Canonical Polyketide Chain Termination , 2020, Angewandte Chemie.

[31]  Jiaqi Li,et al.  Chemical constituents from salt lake-derived Streptomyces sp. QHA10 , 2019, Journal of Asian natural products research.