Sacral nerve stimulation for the treatment of refractory voiding and bowel dysfunction.

Sacral nerve stimulation, sometimes referred to as a "pacemaker for the bladder and bowels" delivers nonpainful, electrical pulses to the sacral nerves to improve or restore function. A relatively simple procedure works via a complex mechanism to modulate the reflexes that influence the bladder, bowels, sphincters, and pelvic floor. Current approved indications include urinary urge incontinence, urgency-frequency, nonobstructive urinary retention, and fecal incontinence. The history, mechanism of action, evolution, and landmark literature for this treatment modality are reviewed.

[1]  G. Webster,et al.  Predicting implantation with a neuromodulator using two different test stimulation techniques: A prospective randomized study in urge incontinent women , 2007, Neurourology and urodynamics.

[2]  K. Peters,et al.  Is sensory testing during lead placement crucial for achieving positive outcomes after sacral neuromodulation? , 2011, Neurourology and urodynamics.

[3]  R. Schmidt,et al.  Sacral root stimulation in controlled micturition. Peripheral somatic neurotomy and stimulated voiding. , 1979, Investigative urology.

[4]  R. Schmidt,et al.  Functional evaluation of sacral nerve root integrity. Report of a technique. , 1990, Urology.

[5]  W. Groat Mechanisms underlying recurrent inhibition in the sacral parasympathetic outflow to the urinary bladder. , 1976 .

[6]  M. Spinelli,et al.  New percutaneous technique of sacral nerve stimulation has high initial success rate: preliminary results. , 2003, European urology.

[7]  A. Leroi,et al.  How sacral nerve stimulation works in patients with faecal incontinence , 2011, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[8]  R. Ryall,et al.  The identification and characteristics of sacral parasympathetic preganglionic neurones , 1968, The Journal of physiology.

[9]  A. Windsor,et al.  Temporary Sacral Nerve Stimulation Alters Rectal Sensory Function: A Physiological Study , 2011, Diseases of the colon and rectum.

[10]  L. Birder,et al.  From urothelial signalling to experiencing a sensation related to the urinary bladder , 2013, Acta physiologica.

[11]  W. C. Groat Inhibition and excitation of sacral parasympathetic neurons by visceral and cutaneous stimuli in the cat. , 1971 .

[12]  R. Schmidt,et al.  Bladder pacemaker: scientific basis and clinical future. , 1982, Urology.

[13]  M. Spinelli,et al.  New sacral neuromodulation lead for percutaneous implantation using local anesthesia: description and first experience. , 2003, The Journal of urology.

[14]  L. Rodríguez,et al.  Short-term results of bilateral S2–S4 sacral neuromodulation for the treatment of refractory interstitial cystitis, painful baldder syndrome, and chronic pelvic pain , 2008, International Urogynecology Journal.

[15]  Cynthia Fraser,et al.  Efficacy and safety of sacral nerve stimulation for urinary urge incontinence: a systematic review. , 2006, The Journal of urology.

[16]  K. Peters,et al.  Sacral neuromodulation decreases narcotic requirements in refractory interstitial cystitis , 2004, BJU international.

[17]  J. Bosch,et al.  Sacral nerve neuromodulation in the treatment of patients with refractory motor urge incontinence: long-term results of a prospective longitudinal study. , 2000, The Journal of urology.

[18]  W. V. van Gemert,et al.  Can Sensory and/or Motor Reactions During Percutaneous Nerve Evaluation Predict Outcome of Sacral Nerve Modulation? , 2009, Diseases of the colon and rectum.

[19]  S. Wexner,et al.  Sacral Nerve Stimulation for Fecal Incontinence: Results of a 120-Patient Prospective Multicenter Study , 2010, Annals of surgery.

[20]  Brian L. Cohen,et al.  Predictors of success for first stage neuromodulation: motor versus sensory response. , 2006, The Journal of urology.

[21]  A. V. van Asselt,et al.  Cost‐effectiveness analysis of sacral neuromodulation for faecal incontinence in the Netherlands , 2012, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[22]  W. C. Groat Nervous control of the urinary bladder of the cat , 1975, Brain Research.

[23]  A. Sharma,et al.  Review of Sacral Neuromodulation for Management of Constipation , 2013, Surgical innovation.

[24]  G. Webster,et al.  Sacral neuromodulation for intractable urge incontinence: are there factors associated with cure? , 2005, Urology.

[25]  K. Peters,et al.  Sacral neuromodulation for the treatment of refractory interstitial cystitis: outcomes based on technique , 2003, International Urogynecology Journal.

[26]  K. Peters,et al.  Sacral versus pudendal nerve stimulation for voiding dysfunction: A prospective, single‐blinded, randomized, crossover trial , 2005, Neurourology and urodynamics.

[27]  M. Joore,et al.  Cost‐effectiveness analysis of sacral neuromodulation and botulinum toxin A treatment for patients with idiopathic overactive bladder , 2011, BJU international.

[28]  J W Arkwright,et al.  Pancolonic motor response to subsensory and suprasensory sacral nerve stimulation in patients with slow‐transit constipation , 2012, The British journal of surgery.

[29]  B S Nashold,et al.  Electrical activation of micturition by spinal cord stimulation. , 1971, The Journal of surgical research.

[30]  S. Wexner,et al.  Long-term Efficacy and Safety of Sacral Nerve Stimulation for Fecal Incontinence , 2011, Diseases of the colon and rectum.

[31]  M. Chancellor,et al.  Principles of Sacral Nerve Stimulation (SNS) for the Treatment of Bladder and Urethral Sphincter Dysfunctions , 2000, Neuromodulation : journal of the International Neuromodulation Society.

[32]  Jennifer M Wu,et al.  Cost-effectiveness of sacral neuromodulation versus intravesical botulinum A toxin for treatment of refractory urge incontinence. , 2009, The Journal of urology.

[33]  R. Schmidt,et al.  Electrical stimulation in the clinical management of the neurogenic bladder. , 1988, The Journal of urology.

[34]  I. Cook,et al.  Sacral nerve stimulation induces pan‐colonic propagating pressure waves and increases defecation frequency in patients with slow‐transit constipation , 2007, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[35]  K. Burgio,et al.  Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline. , 2012, The Journal of urology.

[36]  R. Ryall,et al.  Recurrent inhibition in sacral parasympathetic pathways to the bladder , 1968, The Journal of physiology.

[37]  C. Thompson,et al.  National community prevalence of overactive bladder in the United States stratified by sex and age. , 2011, Urology.

[38]  S. Menefee,et al.  Sacral neuromodulation: cost considerations and clinical benefits. , 2007, Urology.

[39]  Dick J Veltman,et al.  Different brain effects during chronic and acute sacral neuromodulation in urge incontinent patients with implanted neurostimulators , 2006, BJU international.

[40]  A. Lowry,et al.  Faecal incontinence in adults , 2004, The Lancet.

[41]  J. Tjandra,et al.  Sacral Nerve Stimulation is more Effective than Optimal Medical Therapy for Severe Fecal Incontinence: A Randomized, Controlled Study , 2008, Diseases of the colon and rectum.

[42]  E. Tanagho,et al.  Studies on the feasibility of urinary bladder evacuation by direct spinal cord stimulation. I. Parameters of most effective stimulation. , 1975, Investigative urology.

[43]  P. Marque,et al.  Sacral neuromodulation for treating neurogenic bladder dysfunction: Clinical and urodynamic study , 2011, Neurourology and urodynamics.

[44]  M. Elhilali,et al.  Results of sacral neuromodulation therapy for urinary voiding dysfunction: outcomes of a prospective, worldwide clinical study. , 2007, The Journal of urology.