Natural killer cells and tumor metastasis

[1]  Yoon Dae Han,et al.  IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours , 2017, Nature Communications.

[2]  D. Yoon,et al.  Interleukin 32, inflammation and cancer , 2017, Pharmacology & therapeutics.

[3]  Y. Zhuang,et al.  Tumor-Associated Monocytes/Macrophages Impair NK-Cell Function via TGFβ1 in Human Gastric Cancer , 2017, Cancer Immunology Research.

[4]  Meijuan Huang,et al.  High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer , 2017, Oncoimmunology.

[5]  Yan Chen,et al.  Human fused NKG2D–IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells , 2015, Cellular and Molecular Immunology.

[6]  M. Roberti,et al.  Phenotypic and Functional Dysregulated Blood NK Cells in Colorectal Cancer Patients Can Be Activated by Cetuximab Plus IL-2 or IL-15 , 2016, Front. Immunol..

[7]  G. Lal,et al.  Intratumoral natural killer cells show reduced effector and cytolytic properties and control the differentiation of effector Th1 cells , 2016, Oncoimmunology.

[8]  T. Stankovic,et al.  NK cell function is markedly impaired in patients with chronic lymphocytic leukaemia but is preserved in patients with small lymphocytic lymphoma , 2016, Oncotarget.

[9]  R. Morgan,et al.  Mammary-tumor-educated B cells acquire LAP/TGF-β and PD-L1 expression and suppress anti-tumor immune responses. , 2016, International immunology.

[10]  N. Hynes,et al.  Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models , 2016, Nature Communications.

[11]  H. Fujii,et al.  Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility , 2016, Journal of Gastroenterology.

[12]  C. Sohn,et al.  Neutrophil Granulocytes in Ovarian Cancer - Induction of Epithelial-To-Mesenchymal-Transition and Tumor Cell Migration , 2016, Journal of Cancer.

[13]  D. Olive,et al.  PD-L1 expression in metastatic neuroblastoma as an additional mechanism for limiting immune surveillance , 2016, Oncoimmunology.

[14]  B. Lambrecht,et al.  Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection , 2015, The Journal of experimental medicine.

[15]  A. Buqué,et al.  Podocalyxin-like protein 1 functions as an immunomodulatory molecule in breast cancer cells. , 2015, Cancer letters.

[16]  M. Ma,et al.  Low expression of Bin1, along with high expression of IDO in tumor tissue and draining lymph nodes, are predictors of poor prognosis for esophageal squamous cell cancer patients , 2015, International journal of cancer.

[17]  D. Gabrilovich,et al.  Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. , 2015, The Journal of clinical investigation.

[18]  Zhaohui Hu,et al.  Interleukin-32 stimulates osteosarcoma cell invasion and motility via AKT pathway-mediated MMP-13 expression. , 2015, International journal of molecular medicine.

[19]  A. Schambach,et al.  Advantages and applications of CAR-expressing natural killer cells , 2015, Front. Pharmacol..

[20]  Lili Tang,et al.  IL-32 promotes breast cancer cell growth and invasiveness , 2014, Oncology letters.

[21]  K. Baumstarck,et al.  Expression of activating receptors on natural killer cells from AIDS-related lymphoma patients , 2014, AIDS Research and Therapy.

[22]  Badrinath Roysam,et al.  Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells. , 2014, Blood.

[23]  F. Shi,et al.  NK Cell Phenotypic Modulation in Lung Cancer Environment , 2014, PloS one.

[24]  Y. Miao,et al.  Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunction , 2014, BMC Cancer.

[25]  Lixia Diao,et al.  Metastasis is regulated via microRNA-200/ZEB1 axis control of tumor cell PD-L1 expression and intratumoral immunosuppression , 2014, Nature Communications.

[26]  L. Weiner,et al.  CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets. , 2014, Blood.

[27]  Cheng‐Yi Chen,et al.  Interleukin-32 Increases Human Gastric Cancer Cell Invasion Associated with Tumor Progression and Metastasis , 2014, Clinical Cancer Research.

[28]  F. Locatelli,et al.  Natural Killer Cells and Neuroblastoma: Tumor Recognition, Escape Mechanisms, and Possible Novel Immunotherapeutic Approaches , 2014, Front. Immunol..

[29]  H. Kohrt,et al.  Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies. , 2013, Blood.

[30]  Y. Miao,et al.  Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer , 2013, Journal of Translational Medicine.

[31]  L. Moretta,et al.  Hypoxia downregulates the expression of activating receptors involved in NK‐cell‐mediated target cell killing without affecting ADCC , 2013, European journal of immunology.

[32]  J. Coligan,et al.  Membrane-Type 6 Matrix Metalloproteinase Regulates the Activation-Induced Downmodulation of CD16 in Human Primary NK Cells , 2013, The Journal of Immunology.

[33]  Tinghong Ye,et al.  Enhanced interaction between natural killer cells and lung cancer cells: involvement in gefitinib-mediated immunoregulation , 2013, Journal of Translational Medicine.

[34]  G. Konjević,et al.  Distribution of several activating and inhibitory receptors on CD3(-)CD56(+) NK cells in regional lymph nodes of melanoma patients. , 2013, The Journal of surgical research.

[35]  Wei Liu,et al.  Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity , 2013, Medical Oncology.

[36]  G. Peruzzi,et al.  Matrix metalloproteinases inhibition promotes the polyfunctionality of human natural killer cells in therapeutic antibody‐based anti‐tumour immunotherapy , 2013, Clinical and experimental immunology.

[37]  P. Xie,et al.  M2-polarized tumor-associated macrophages promoted epithelial–mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway , 2013, Laboratory Investigation.

[38]  F. Locatelli,et al.  Neuroblastoma-Derived TGF-β1 Modulates the Chemokine Receptor Repertoire of Human Resting NK Cells , 2013, The Journal of Immunology.

[39]  M. Hallek,et al.  Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity. , 2013, Blood.

[40]  A. G. de Herreros,et al.  Epithelial–Mesenchymal Transition Induces an Antitumor Immune Response Mediated by NKG2D Receptor , 2013, The Journal of Immunology.

[41]  A. Lin,et al.  Multiple steps of HLA-G in ovarian carcinoma metastasis: alter NK cytotoxicity and induce matrix metalloproteinase-15 (MMP-15) expression. , 2013, Human immunology.

[42]  D. Campana,et al.  A chimeric receptor with NKG2D specificity enhances natural killer cell activation and killing of tumor cells. , 2013, Cancer research.

[43]  Jeffrey S. Miller,et al.  Natural killer cells: a review of manufacturing and clinical utility , 2013, Transfusion.

[44]  X. Mo,et al.  Invasion-associated genes identified by gene expression profiling in extranodal natural killer/T-cell lymphoma, nasal type , 2013, Leukemia & lymphoma.

[45]  J. Carvalho,et al.  Molecular link mechanisms between inflammation and cancer. , 2012, Current pharmaceutical design.

[46]  Stefan Heinrichs,et al.  Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells. , 2012, The Journal of clinical investigation.

[47]  H. Kohrt,et al.  Combination strategies to enhance antitumor ADCC. , 2012, Immunotherapy.

[48]  Wei Liu,et al.  Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO. , 2012, Cancer letters.

[49]  D. Ahn,et al.  Dysregulation of overexpressed IL-32α in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-κB and Bcl-2. , 2012, Cancer letters.

[50]  Alison P. Klein,et al.  Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape , 2012, Science Translational Medicine.

[51]  Douglas Hanahan,et al.  Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment Prospects and Obstacles for Therapeutic Targeting of Function-enabling Stromal Cell Types , 2022 .

[52]  Baptiste N. Jaeger,et al.  Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis , 2012, The Journal of experimental medicine.

[53]  H. Putter,et al.  NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study , 2012, BMC Cancer.

[54]  I. Ng,et al.  Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma , 2011, Gut.

[55]  F. Bertucci,et al.  Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity. , 2011, The Journal of clinical investigation.

[56]  P. Validire,et al.  Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma. , 2011, Cancer research.

[57]  R. Solana,et al.  Human NK cells in acute myeloid leukaemia patients: analysis of NK cell-activating receptors and their ligands , 2011, Cancer Immunology, Immunotherapy.

[58]  Dahui Sun,et al.  MMP9 mediates MICA shedding in human osteosarcomas , 2011, Cell biology international.

[59]  M. Neurath,et al.  IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. , 2011, Cytokine & growth factor reviews.

[60]  M. Koch,et al.  Natural Killer Cells are Scarce in Colorectal Carcinoma Tissue Despite High Levels of Chemokines and Cytokines , 2011, Clinical Cancer Research.

[61]  Hyeyoung Min,et al.  Overexpression of IL-32α Increases Natural Killer Cell-mediated Killing through Up-regulation of Fas and UL16-binding protein 2 (ULBP2) Expression in Human Chronic Myeloid Leukemia Cells* , 2011, The Journal of Biological Chemistry.

[62]  F. Locatelli,et al.  Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation. , 2011, Blood.

[63]  A. Mantovani,et al.  The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes , 2010, Proceedings of the National Academy of Sciences.

[64]  Gang Liu,et al.  Cutting Edge: The Membrane Type Matrix Metalloproteinase MMP14 Mediates Constitutive Shedding of MHC Class I Chain-Related Molecule A Independent of A Disintegrin and Metalloproteinases , 2010, The Journal of Immunology.

[65]  M. Karin,et al.  Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. , 2010, Cytokine & growth factor reviews.

[66]  A. Schetter,et al.  Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. , 2010, Carcinogenesis.

[67]  P. Queirolo,et al.  Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity , 2009, Proceedings of the National Academy of Sciences.

[68]  M. Manns,et al.  Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor , 2009, Hepatology.

[69]  P. Kuppen,et al.  Human NK cell lines migrate differentially in vitro related to matrix interaction and MMP expression , 2009, Immunology and cell biology.

[70]  B. Walker,et al.  Matrix Metalloprotease Inhibitors Restore Impaired NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Human Immunodeficiency Virus Type 1 Infection , 2009, Journal of Virology.

[71]  A. Daneri-Navarro,et al.  Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions , 2009, BMC Cancer.

[72]  Raghu Kalluri,et al.  The basics of epithelial-mesenchymal transition. , 2009, The Journal of clinical investigation.

[73]  F. Balkwill.  Tumour necrosis factor and cancer , 2009, Nature Reviews Cancer.

[74]  J. Pollard,et al.  Microenvironmental regulation of metastasis , 2009, Nature Reviews Cancer.

[75]  R. Weinberg,et al.  Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits , 2009, Nature Reviews Cancer.

[76]  P. Choung,et al.  A high concentration of MMP-2/gelatinase A and MMP-9/gelatinase B reduce NK cell-mediated cytotoxicity against an oral squamous cell carcinoma cell line. , 2008, In vivo.

[77]  Lai-Xi Wang,et al.  Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies. , 2008, Blood.

[78]  Eric Vivier,et al.  Functions of natural killer cells , 2008, Nature Immunology.

[79]  M. Karin,et al.  The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. , 2008, Trends in molecular medicine.

[80]  C. Harris,et al.  Inflammation and cancer: An ancient link with novel potentials , 2007, International journal of cancer.

[81]  A. Thiel,et al.  CD56brightCD16− Killer Ig-Like Receptor− NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation1 , 2007, The Journal of Immunology.

[82]  N. Minato,et al.  SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion , 2007, Nature Genetics.

[83]  B. Ryffel,et al.  Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4+CD25- T lymphocytes. , 2007, Experimental hematology.

[84]  Hua Yu,et al.  Tumour immunology: Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment , 2007, Nature Reviews Immunology.

[85]  L. Moretta,et al.  The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function. , 2006, Blood.

[86]  L. Zitvogel,et al.  The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression , 2006, Immunological reviews.

[87]  C. Le,et al.  Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. , 2005, Blood.

[88]  L. Moretta,et al.  IL-12 or IL-4 Prime Human NK Cells to Mediate Functionally Divergent Interactions with Dendritic Cells or Tumors1 , 2005, The Journal of Immunology.

[89]  F. Vély,et al.  Coordination of activating and inhibitory signals in natural killer cells. , 2005, Molecular immunology.

[90]  S. Latour,et al.  Molecular Dissection of 2B4 Signaling: Implications for Signal Transduction by SLAM-Related Receptors , 2004, Molecular and Cellular Biology.

[91]  Dolca Thomas,et al.  The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic1 , 2004, The Journal of Immunology.

[92]  M. Caligiuri,et al.  What does it take to make a natural killer? , 2003, Nature Reviews Immunology.

[93]  R. Biassoni,et al.  Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[94]  P. Schwartzberg,et al.  Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation , 2003, Nature Cell Biology.

[95]  B. Zhong,et al.  Syk Regulation of Phosphoinositide 3-Kinase-Dependent NK Cell Function1 , 2002, The Journal of Immunology.

[96]  Hiroaki Ikeda,et al.  The roles of IFN gamma in protection against tumor development and cancer immunoediting. , 2002, Cytokine & growth factor reviews.

[97]  K. Kärre.  Immunology. A perfect mismatch. , 2002, Science.

[98]  M. Caligiuri,et al.  The biology of human natural killer-cell subsets. , 2001, Trends in immunology.

[99]  P. Leibson,et al.  Regulation of NK Cell-Mediated Cytotoxicity by the Adaptor Protein 3BP21 , 2001, The Journal of Immunology.

[100]  Alberto Mantovani,et al.  Inflammation and cancer: back to Virchow? , 2001, The Lancet.

[101]  R. Biassoni,et al.  Immunobiology of human NK cells. , 2001, Transplantation proceedings.

[102]  K. Nakachi,et al.  Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population , 2000, The Lancet.

[103]  Thiennu H. Vu,et al.  Matrix metalloproteinases: effectors of development and normal physiology. , 2000, Genes & development.

[104]  D. Doherty,et al.  Innate and adaptive lymphoid cells in the human liver , 2000, Immunological reviews.

[105]  F. Marincola,et al.  Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. , 2000, Advances in immunology.

[106]  A Steinle,et al.  Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. , 1999, Science.

[107]  Jun Wu,et al.  An activating immunoreceptor complex formed by NKG2D and DAP10. , 1999, Science.

[108]  Eric O Long,et al.  Regulation of immune responses through inhibitory receptors. , 1999, Annual review of immunology.

[109]  E. Alnemri,et al.  Natural Killer (NK) Cell–mediated Cytotoxicity: Differential Use of  TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells , 1998, The Journal of experimental medicine.

[110]  X. Bustelo,et al.  The Vav–Rac1 Pathway in Cytotoxic Lymphocytes Regulates the Generation of Cell-mediated Killing , 1998, The Journal of experimental medicine.

[111]  Jin Hong Liu,et al.  Control of Lytic Function by Mitogen-activated Protein Kinase/Extracellular Regulatory Kinase 2 (ERK2) in a Human Natural Killer Cell Line: Identification of Perforin and Granzyme B Mobilization by Functional ERK2 , 1998, The Journal of experimental medicine.

[112]  J. Bell,et al.  HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C , 1998, Nature.

[113]  L. Frati,et al.  Selective binding of shc-SH2 domain to tyrosine-phosphorylated zeta but not gamma-chain upon CD16 ligation on human NK cells. , 1997, Journal of immunology.

[114]  M. Llano,et al.  Structure and function of the CD94 C‐type lectin receptor complex involved in recognition of HLA class I molecules , 1997, Immunological reviews.

[115]  R. Biassoni,et al.  Receptors for HLA class-I molecules in human natural killer cells. , 1996, Annual review of immunology.

[116]  R. Abraham,et al.  Interaction between lck and syk Family Tyrosine Kinases in Fcγ Receptor-initiated Activation of Natural Killer Cells (*) , 1995, The Journal of Biological Chemistry.

[117]  W. Seaman,et al.  NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity , 1995, The Journal of experimental medicine.

[118]  Huiling He,et al.  Identification of a novel gene expressed in activated natural killer cells and T cells. , 1992, Journal of immunology.

[119]  A. Chang,et al.  Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. , 1985, The New England journal of medicine.