Clinical and therapeutic relevance of cancer-associated fibroblasts

[1]  P. Neven,et al.  A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer , 2021, Nature Medicine.

[2]  R. Schwabe,et al.  Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts. , 2021, The Journal of clinical investigation.

[3]  Deshka S. Foster,et al.  Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring , 2021, Science.

[4]  R. Schwabe,et al.  Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. , 2021, Cancer cell.

[5]  Xiuzhen Huang,et al.  A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting. , 2021, Cell stem cell.

[6]  T. H. van der Kwast,et al.  Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression , 2021, Nature Cell Biology.

[7]  R. Kalluri,et al.  Stromal Cells Exhibit Prevalent Genetic Aberrations in Colorectal Cancer. , 2020, Cancer cell.

[8]  J. Hasty,et al.  The balance of stromal BMP signaling mediated by GREM1 and ISLR drives colorectal carcinogenesis. , 2020, Gastroenterology.

[9]  F. Mechta-Grigoriou,et al.  Fibroblast heterogeneity in tumor micro-environment: Role in immunosuppression and new therapies. , 2020, Seminars in immunology.

[10]  F. Tang,et al.  Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer. , 2020, Cancer cell.

[11]  M. Xiong,et al.  Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma , 2020, Nature Communications.

[12]  H. Takayanagi,et al.  Fibroblasts as a source of self-antigens for central immune tolerance , 2020, Nature Immunology.

[13]  X. Liu,et al.  Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer , 2020, The EMBO journal.

[14]  Keith E. Volmar,et al.  Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix. , 2020, The Journal of clinical investigation.

[15]  Joon-Oh Park,et al.  Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma , 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[16]  Uri Alon,et al.  Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome , 2020, Nature Cancer.

[17]  K. Pietras,et al.  Heterogeneity of cancer‐associated fibroblasts: Opportunities for precision medicine , 2020, Cancer science.

[18]  Vianne R. Gao,et al.  Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer , 2020, Cancer cell.

[19]  S. Raza,et al.  Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer. , 2020, Cell reports.

[20]  D. Tuveson,et al.  DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS. , 2020, Physiological reviews.

[21]  H. Wen,et al.  Differential Contribution of Pancreatic Fibroblast Subsets to the Pancreatic Cancer Stroma , 2020, Cellular and molecular gastroenterology and hepatology.

[22]  M. Lenardo,et al.  A guide to cancer immunotherapy: from T cell basic science to clinical practice , 2020, Nature Reviews Immunology.

[23]  K. Tarte,et al.  Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer. , 2020, Cancer discovery.

[24]  S. Teichmann,et al.  Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth , 2020, Cell reports.

[25]  S. Nagarajan,et al.  GRP78 and next generation cancer hallmarks: An underexplored molecular target in cancer chemoprevention research. , 2020, Biochimie.

[26]  S. Gygi,et al.  Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer. , 2020, Cancer discovery.

[27]  Deepali V. Sawant,et al.  Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer , 2020, Cell.

[28]  A. Schneeweiss,et al.  Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs , 2020, Nature Communications.

[29]  Erin Helms,et al.  Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment. , 2020, Cancer discovery.

[30]  Thea D. Tlsty,et al.  A framework for advancing our understanding of cancer-associated fibroblasts , 2020, Nature Reviews Cancer.

[31]  A. Vincent-Salomon,et al.  Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms , 2020, Nature Communications.

[32]  R. Bourgon,et al.  Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy. , 2019, Cancer discovery.

[33]  N. Erez,et al.  NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis , 2019, Nature Communications.

[34]  D. Lauffenburger,et al.  Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance. , 2019, Cancer research.

[35]  S. Yamada,et al.  Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis. , 2019, Cancer research.

[36]  David R. Croucher,et al.  CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan , 2019, Nature Communications.

[37]  N. Erez,et al.  The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment , 2019, Front. Immunol..

[38]  P. Robson,et al.  Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. , 2019, Cancer discovery.

[39]  L. Sevenich,et al.  Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis , 2019, Front. Immunol..

[40]  W. Vainchenker.  Faculty Opinions recommendation of Somatic mutations and cell identity linked by Genotyping of Transcriptomes. , 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[41]  Yun-Gui Yang,et al.  Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma , 2019, Cell Research.

[42]  Joseph M. Scandura,et al.  Genotyping of Transcriptomes links somatic mutations and cell identity , 2019, Nature.

[43]  Martin J. Aryee,et al.  Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer , 2019, Cell.

[44]  S. Hingorani,et al.  Fibroblasts in Pancreatic Ductal Adenocarcinoma: Biological Mechanisms and Therapeutic Targets. , 2019, Gastroenterology.

[45]  R. Jain,et al.  Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy , 2019, Proceedings of the National Academy of Sciences.

[46]  Galina A. Erikson,et al.  Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring , 2019, Nature.

[47]  R. Sears,et al.  A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression. , 2019, Cancer discovery.

[48]  P. Philip,et al.  Phase IB/II Randomized Study of FOLFIRINOX Plus Pegylated Recombinant Human Hyaluronidase Versus FOLFIRINOX Alone in Patients With Metastatic Pancreatic Adenocarcinoma: SWOG S1313. , 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[49]  A. Maitra,et al.  Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution , 2019, bioRxiv.

[50]  J. Vijg,et al.  Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan , 2019, Proceedings of the National Academy of Sciences.

[51]  M. Hemberg,et al.  Challenges in unsupervised clustering of single-cell RNA-seq data , 2019, Nature Reviews Genetics.

[52]  D. Bulavin,et al.  Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy. , 2019, Cell metabolism.

[53]  Åsa K. Björklund,et al.  Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing , 2018, Nature Communications.

[54]  R. Kalluri,et al.  Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis , 2018, PLoS biology.

[55]  Carmit Levy,et al.  Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer , 2018, The Journal of experimental medicine.

[56]  D. Tuveson,et al.  IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. , 2018, Cancer discovery.

[57]  D. Saur,et al.  Dual reporter genetic mouse models of pancreatic cancer identify an epithelial‐to‐mesenchymal transition‐independent metastasis program , 2018, EMBO molecular medicine.

[58]  P. Carmeliet,et al.  Phenotype molding of stromal cells in the lung tumor microenvironment , 2018, Nature Medicine.

[59]  Yan Zhou,et al.  Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression , 2018, bioRxiv.

[60]  P. Scheet,et al.  Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression , 2018, Clinical Cancer Research.

[61]  A. Vincent-Salomon,et al.  miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers , 2018, Nature Communications.

[62]  Inna Kuperstein,et al.  Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer. , 2018, Cancer cell.

[63]  C. Martins,et al.  Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells , 2018, Nature Communications.

[64]  Camille Stephan-Otto Attolini,et al.  TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis , 2018, Nature.

[65]  H. Yao,et al.  CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness , 2018, Cell.

[66]  R. Bourgon,et al.  TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells , 2018, Nature.

[67]  Judy M. Anderson,et al.  Stromal Content Is Correlated With Tissue Site, Contrast Retention, and Survival in Pancreatic Adenocarcinoma. , 2018, JCO precision oncology.

[68]  Peter J. Park,et al.  Aging and neurodegeneration are associated with increased mutations in single human neurons , 2017, Science.

[69]  Chunsheng Zhang,et al.  Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. , 2017, Cancer cell.

[70]  Shawn M. Gillespie,et al.  Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer , 2017, Cell.

[71]  C. Lindskog,et al.  A pathology atlas of the human cancer transcriptome , 2017, Science.

[72]  M. V. Vander Heiden,et al.  Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions , 2017, Nature Communications.

[73]  L. J. K. Wee,et al.  Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors , 2017, Nature Genetics.

[74]  L. J. K. Wee,et al.  Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors , 2017, Nature Genetics.

[75]  D. Tuveson,et al.  Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer , 2017, The Journal of experimental medicine.

[76]  A. Benson,et al.  A Phase II, Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second‐Line Treatment of Metastatic KRAS Mutant Colorectal Adenocarcinoma , 2017, The oncologist.

[77]  A. Benson,et al.  A Phase II Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First‐Line Treatment of Pancreatic Adenocarcinoma , 2017, The oncologist.

[78]  R. Kalluri.  The biology and function of fibroblasts in cancer , 2016, Nature Reviews Cancer.

[79]  R. Hill,et al.  CANCER-ASSOCIATED FIBROBLAST EXOSOMES REGULATE SURVIVAL AND PROLIFERATION OF PANCREATIC CANCER CELLS , 2016, Oncogene.

[80]  L. Cantley,et al.  Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion , 2016, Nature.

[81]  Yuli Lin,et al.  FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling. , 2016, Cancer research.

[82]  R. Weichselbaum,et al.  Tumor-associated fibroblasts predominantly come from local and not circulating precursors , 2016, Proceedings of the National Academy of Sciences.

[83]  J. Erler,et al.  Fibrosis and Cancer: Partners in Crime or Opposing Forces? , 2016, Trends in cancer.

[84]  Christine A Iacobuzio-Donahue,et al.  Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular-fibrosis and tumor progression , 2016, Nature Medicine.

[85]  Crispin J. Miller,et al.  Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation , 2016, Cell.

[86]  Ken Chen,et al.  Monovar: single nucleotide variant detection in single cells , 2016, Nature Methods.

[87]  M. Vannier,et al.  A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma , 2016, Pancreas.

[88]  Prahlad T. Ram,et al.  Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism , 2016, eLife.

[89]  Umar Mahmood,et al.  Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. , 2015, Cancer cell.

[90]  R. Salgia,et al.  Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[91]  R. Schreiber,et al.  Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression , 2015, Cell.

[92]  D. Tuveson,et al.  Stromal biology and therapy in pancreatic cancer: a changing paradigm , 2015, Gut.

[93]  Lei Mu,et al.  Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer , 2015, PloS one.

[94]  Erik Sahai,et al.  Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling , 2015, Cancer cell.

[95]  Christian Veltkamp,et al.  A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer , 2014, Nature Medicine.

[96]  D. Sahoo,et al.  Hedgehog signaling restrains bladder cancer progression by eliciting stromal production of urothelial differentiation factors. , 2014, Cancer cell.

[97]  G. Wahl,et al.  Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy , 2014, Cell.

[98]  Y. Okada,et al.  Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state , 2014, Nature Cell Biology.

[99]  Daniel Öhlund,et al.  Fibroblast heterogeneity in the cancer wound , 2014, The Journal of experimental medicine.

[100]  J. Willmann,et al.  Stromal response to Hedgehog signaling restrains pancreatic cancer progression , 2014, Proceedings of the National Academy of Sciences.

[101]  Stephen A. Sastra,et al.  Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. , 2014, Cancer cell.

[102]  L. Chin,et al.  Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. , 2014, Cancer cell.

[103]  J. Wrana,et al.  Free somatostatin receptor fraction predicts the antiproliferative effect of octreotide in a neuroendocrine tumor model: implications for dose optimization. , 2013, Cancer research.

[104]  Derek S. Chan,et al.  Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer , 2013, Proceedings of the National Academy of Sciences.

[105]  D. Quail,et al.  Microenvironmental regulation of tumor progression and metastasis , 2013, Nature Medicine.

[106]  Fiona M. Watt,et al.  Distinct fibroblast lineages determine dermal architecture in skin development and repair , 2013, Nature.

[107]  C. Dray,et al.  Adipocyte-derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer. , 2013, Cancer research.

[108]  R. Kalluri,et al.  Origin and function of myofibroblasts in kidney fibrosis , 2013, Nature Medicine.

[109]  D. Stainier,et al.  Hepatic stellate cells in liver development, regeneration, and cancer. , 2013, The Journal of clinical investigation.

[110]  R. Kalluri,et al.  Exosomes in tumor microenvironment influence cancer progression and metastasis , 2013, Journal of Molecular Medicine.

[111]  F. Couch,et al.  Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation* , 2013, The Journal of Biological Chemistry.

[112]  V. LeBleu,et al.  Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis , 2013, Nature Medicine.

[113]  P. Jänne,et al.  Resistance to irreversible EGF receptor tyrosine kinase inhibitors through a multistep mechanism involving the IGF1R pathway. , 2013, Cancer research.

[114]  Derek S. Chan,et al.  The Pancreas Cancer Microenvironment , 2012, Clinical Cancer Research.

[115]  Carlos Cuevas,et al.  Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.

[116]  R. Kalluri,et al.  The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis. , 2011, Genes & cancer.

[117]  Hans Clevers,et al.  Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression. , 2011, Gastroenterology.

[118]  Raghu Kalluri,et al.  VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization , 2011, Proceedings of the National Academy of Sciences.

[119]  A. Ochiai,et al.  Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression. , 2011, Cancer research.

[120]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[121]  H. Tomita,et al.  Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. , 2011, Cancer cell.

[122]  D. Kranz.  Faculty Opinions recommendation of Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. , 2010 .

[123]  James O. Jones,et al.  Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α , 2010, Science.

[124]  Mikala Egeblad,et al.  Dynamic interplay between the collagen scaffold and tumor evolution. , 2010, Current opinion in cell biology.

[125]  Kristian Pietras,et al.  Hallmarks of cancer: interactions with the tumor stroma. , 2010, Experimental cell research.

[126]  Mikala Egeblad,et al.  Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling , 2009, Cell.

[127]  G. Cheng,et al.  Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. , 2009, Cancer cell.

[128]  Robert A. Gatenby,et al.  Environment-mediated drug resistance: a major contributor to minimal residual disease , 2009, Nature Reviews Cancer.

[129]  David Allard,et al.  Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer , 2009, Science.

[130]  P. Chambon,et al.  Efficient temporally‐controlled targeted mutagenesis in smooth muscle cells of the adult mouse , 2009, Genesis.

[131]  Matthias Schäfer,et al.  Cancer as an overhealing wound: an old hypothesis revisited , 2008, Nature Reviews Molecular Cell Biology.

[132]  J. Mesirov,et al.  Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells. , 2008, Cancer research.

[133]  P. Platzer,et al.  Breast-cancer stromal cells with TP53 mutations and nodal metastases. , 2007, The New England journal of medicine.

[134]  Liang Xie,et al.  Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. , 2007, Cancer research.

[135]  Ross Tubo,et al.  Mesenchymal stem cells within tumour stroma promote breast cancer metastasis , 2007, Nature.

[136]  Murray Korc,et al.  Pancreatic cancer-associated stroma production. , 2007, American journal of surgery.

[137]  Xueli Yuan,et al.  Endothelial-to-mesenchymal transition contributes to cardiac fibrosis , 2007, Nature Medicine.

[138]  D. V. Von Hoff,et al.  Tumor-stroma interactions in pancreatic ductal adenocarcinoma , 2007, Molecular Cancer Therapeutics.

[139]  Mark W. Kieran,et al.  Identification of fibroblast heterogeneity in the tumor microenvironment , 2006, Cancer biology & therapy.

[140]  J. Massagué,et al.  TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. , 2005, Cancer cell.

[141]  Dennis C. Sgroi,et al.  Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion , 2005, Cell.

[142]  A. Buck,et al.  Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. , 2005, Gastroenterology.

[143]  A. Agarwal,et al.  PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells , 2005, Cell.

[144]  J. Iredale,et al.  Type I Collagen Promotes the Malignant Phenotype of Pancreatic Ductal Adenocarcinoma , 2004, Clinical Cancer Research.

[145]  N. Fusenig,et al.  Friends or foes — bipolar effects of the tumour stroma in cancer , 2004, Nature Reviews Cancer.

[146]  Kristian Pietras,et al.  High interstitial fluid pressure — an obstacle in cancer therapy , 2004, Nature Reviews Cancer.

[147]  T. Ratliff.  TGF-Beta Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia , 2004 .

[148]  M. Washington,et al.  TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia , 2004, Science.

[149]  R. Kalluri.  Basement membranes: structure, assembly and role in tumour angiogenesis , 2003, Nature reviews. Cancer.

[150]  L. Coussens,et al.  Inflammation and cancer , 2002, Nature.

[151]  Satoshi Matsumoto,et al.  Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas , 2002, Nature Genetics.

[152]  G. Bratthauer,et al.  Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. , 2000, Cancer research.

[153]  D. Pinkel,et al.  The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis , 1999, Cell.

[154]  M. Korsten,et al.  Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis , 1999, Gut.

[155]  R. Schmid,et al.  Identification, culture, and characterization of pancreatic stellate cells in rats and humans. , 1998, Gastroenterology.

[156]  M. Battegay,et al.  Fibroblasts as efficient antigen-presenting cells in lymphoid organs. , 1995, Science.

[157]  B. Vogelstein,et al.  Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[158]  Zhongyun Dong,et al.  Modulation of tumor cell response to chemotherapy by the organ environment , 1994, Cancer and Metastasis Reviews.

[159]  O. Petersen,et al.  Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. , 1993, Laboratory investigation; a journal of technical methods and pathology.

[160]  Jean Paul Thiery,et al.  Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[161]  H. Dvorak.  Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. , 1986, The New England journal of medicine.

[162]  D. Umetsu,et al.  Antigen presentation by human dermal fibroblasts: activation of resting T lymphocytes. , 1986, Journal of immunology.

[163]  I. M. Neiman,et al.  [Inflammation and cancer]. , 1974, Patologicheskaia fiziologiia i eksperimental'naia terapiia.

[164]  R. Virchow,et al.  Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre , 1861 .

[165]  R. Kalluri,et al.  Type I collagen deletion in α SMA + myofibroblasts enhances immune suppression and accelerates progression of pancreatic cancer , 2021 .

[166]  David Cameron,et al.  A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer , 2009, Nature Medicine.

[167]  F. Jamali,et al.  Single dose pharmacokinetics and bioavailability of glucosamine in the rat. , 2002, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[168]  M J Bissell,et al.  Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. , 1996, Physiological reviews.

[169]  D. Tarin,et al.  Ultrastructural features of wound healing in mouse skin. , 1969, Journal of anatomy.

[170]  Douglas Hanahan,et al.  Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment Prospects and Obstacles for Therapeutic Targeting of Function-enabling Stromal Cell Types , 2022 .