The utility of prolonged outpatient ambulatory EEG

PURPOSE ILAE guidelines recommend the use of prolonged EEG where the diagnosis of epilepsy or the classification of the seizure syndrome is proving difficult. Due to its limited provision, video EEG monitoring is unavailable to many patients under investigation(1). The aim of this study was to examine the utility of the alternate investigation of outpatient ambulatory EEG. METHODS In this retrospective study we analysed 324 consecutive prolonged outpatient ambulatory EEGs lasting 72-96 h (4-5 days), without medication withdrawal. EEG data and the clinical record were reviewed to investigate the utility of the investigation. RESULTS Of 324 studies: 219 (68%) studies gave positive data, 116 (36%) showed interictal epileptiform discharges (IEDs), 167 (52%) had events. 105 (32%) studies were normal. Overall 51% of studies changed management of which 22% of studies changed the diagnosis and 29% of studies refined the diagnosis by classifying the epilepsy into focal or generalised. CONCLUSION The present study confirms the diagnostic utility of outpatient ambulatory EEG in the diagnosis of paroxysmal events.

[1]  Bruce Scheepers,et al.  The misdiagnosis of epilepsy: findings of a population study , 1998, Seizure.

[2]  R. Leroy,et al.  The results of computer-assisted ambulatory 16-channel EEG. , 1994, Electroencephalography and clinical neurophysiology.

[3]  Terence J O'Brien,et al.  Evaluating the Utility of Inpatient Video‐EEG Monitoring , 2004, Epilepsia.

[4]  F. Gilliam,et al.  Self‐reported Seizure Frequency and Time to First Event in the Seizure Monitoring Unit , 2005, Epilepsia.

[5]  K. Johnson,et al.  Induction of psychogenic nonepileptic seizures without placebo , 2000, Neurology.

[6]  J. Ebersole,et al.  Incidence of seizures with phenytoin toxicity , 1985, Neurology.

[7]  Robert C. Wolpert,et al.  A Review of the , 1985 .

[8]  J. Leach,et al.  Epilepsy in the UK: Misdiagnosis, mistreatment, and undertreatment? The Wrexham area epilepsy project , 2005, Seizure.

[9]  H. Goodkin,et al.  Latency to first psychogenic nonepileptic seizure upon admission to inpatient EEG monitoring: Evidence for semiological differences , 2010, Epilepsy & Behavior.

[10]  Lippincott Williams Wilkins Ambulatory cassette EEG in clinical practice , 1986, Neurology.

[11]  M. Salinsky,et al.  Effectiveness of Multiple EEGs in Supporting the Diagnosis of Epilepsy: An Operational Curve , 1987, Epilepsia.

[12]  Jean Gotman,et al.  Recommendations Regarding the Requirements and Applications for Long‐term Recordings in Epilepsy , 2007, Epilepsia.

[13]  R. Van Dyck,et al.  The diagnosis of psychogenic non-epileptic seizures: A review , 1997, Seizure.

[14]  Richard Wennberg Modern electroencephalography: its role in epilepsy management , 2000, Clinical Neurophysiology.

[15]  J. Ebersole,et al.  The clinical utility of ambulatory cassette EEG , 1985, Neurology.

[16]  Orrin Devinsky,et al.  Epilepsy and Behavior , 1991 .

[17]  E. Passaro,et al.  Outpatient Seizure Identification: Results of 502 Patients Using Computer-Assisted Ambulatory EEG , 2001, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[18]  J. Duncan,et al.  Evaluation of the accuracy of seizure descriptions by the relatives of patients with epilepsy , 2001, Epilepsy Research.

[19]  A. Mohamed,et al.  Latency to first interictal epileptiform discharge in epilepsy with outpatient ambulatory EEG , 2012, Clinical Neurophysiology.

[20]  J. Heo,et al.  Reliability of Semiology Description , 2008, The neurologist.

[21]  C. Binnie,et al.  Glossar der meistgebrauchten Begriffe in der klinischen Elektroenzephalographie und Vorschläge für die EEG-Befunderstellung , 2004 .

[22]  J. Ebersole,et al.  Evaluation of ambulatory cassette EEG monitoring , 1983, Neurology.

[23]  G. Morris,et al.  Clinical utility of sleep-deprived versus computer-assisted ambulatory 16-channel EEG in epilepsy patients: a multi-center study , 1998, Epilepsy Research.

[24]  S. Smith,et al.  Long term monitoring in refractory epilepsy: the Gowers Unit experience , 2008, Journal of Neurology, Neurosurgery, and Psychiatry.

[25]  C. Baumgartner,et al.  Occurrence of epileptiform activity in the routine EEG of epileptic patients , 1993, Acta neurologica Scandinavica.

[26]  J. Ebersole,et al.  An evaluation of ambulatory, cassette EEG monitoring , 1983, Neurology.