Motor effects of globus pallidus stimulation in the rat: lesions to corticofugal fibers block the motor effects

Unilateral electrical stimulation of the globus pallidus (GP) in anesthetized male rats was used to determine the nature of the activity driven in muscles of the neck and shoulder by GP output. In 6 groups of animals stimulation was coupled with lesions to sites that interrupted corticofugal fibers or GP output. Interruption of corticofugal fibers blocked the driven activity while lesions that compromised GP output left the activity unaffected.

[1]  A. Cools Chemical and electrical stimulation of the caudate nucleus in freely moving cats: the role of dopamine. , 1973, Brain research.

[2]  J. Delgado,et al.  Behavioral inhibition induced by pallidal stimulation in monkeys , 1975, Experimental Neurology.

[3]  N. A. Buchwald,et al.  Evoked potentials and behavior; a study of responses to subcortical stimulation in the awake, unrestrained animal. , 1957, Electroencephalography and clinical neurophysiology.

[4]  I. Grofová,et al.  Origin of ascending and spinal pathways from the nucleus tegmenti pedunculopontinus in the rat , 1989, The Journal of comparative neurology.

[5]  J. Penney,et al.  Striatal inhomogeneities and basal ganglia function , 1986, Movement disorders : official journal of the Movement Disorder Society.

[6]  Coyle Jt Neurotoxic action of kainic acid. , 1983 .

[7]  C. Pycock Turning behaviour in animals , 1980, Neuroscience.

[8]  J. Penney,et al.  Speculations on the functional anatomy of basal ganglia disorders. , 1983, Annual review of neuroscience.

[9]  A. Dray The striatum and substantia nigra: A commentary on their relationships , 1979, Neuroscience.

[10]  R. Hassler,et al.  Motor Effects Elicited by Stimulation of the Pallido-thalamic System in the Cat , 1964 .

[11]  A. Jackson,et al.  Basal ganglia and other afferent projections to the peribrachial region in the rat: A study using retrograde and anterograde transport of horseradish peroxidase , 1981, Neuroscience.

[12]  R. Hassler,et al.  Locomotor movements in opposite directions induced by stimulation of pallidum or of putamen. , 1969, Journal of the neurological sciences.

[13]  D. Kooy,et al.  The organization of the efferent projections and striatal afferents of the entopeduncular nucleus and adjacent areas in the rat , 1981, Brain Research.

[14]  J. Olney,et al.  Kainic acid: a powerful neurotoxic analogue of glutamate. , 1974, Brain research.

[15]  The neurological basis of striatally induced head-turning in the rat: The effects of lesions in putative output pathways , 1980, Neuroscience.

[16]  J. W. Ward,et al.  Responses to electrical stimulation of caudate nucleus in cats in chronic experiments. , 1957, Journal of neurophysiology.

[17]  Rudolf Hebel,et al.  Anatomy of the Laboratory Rat , 1976 .

[18]  M. Kelland,et al.  Inhibition and excitation of neck and shoulder muscles during unilateral electrical stimulation of the rat neostriatum , 1988, Behavioural Brain Research.

[19]  A M Graybiel,et al.  The afferent and efferent connections of the feline nucleus tegmenti pedunculopontinus, pars compacta , 1983, The Journal of comparative neurology.

[20]  G. Paxinos The Rat nervous system , 1985 .

[21]  C D Marsden,et al.  Function of the Basal Ganglia as Revealed by Cognitive and Motor Disorders in Parkinson’s Disease , 1984, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[22]  R. White,et al.  Circus movements and excitation of striatal and mesodiencephalic centers in rabbits. , 1957, Journal of neurophysiology.

[23]  H. Mclennan,et al.  SOME BEHAVIORAL EFFECTS OF STIMULATION OF THE CAUDATE NUCLEUS IN UNRESTRAINED CATS. , 1964, Canadian journal of physiology and pharmacology.

[24]  S. D. Glick,et al.  Rotation and stereotypy during electrical stimulation of the caudate nucleus. , 1974, Research communications in chemical pathology and pharmacology.

[25]  G. E. Alexander,et al.  Parallel organization of functionally segregated circuits linking basal ganglia and cortex. , 1986, Annual review of neuroscience.