An Isothermal Titration Calorimeter

A new isothermal titration calorimeter has been designed to facilitate the study of heats of reaction and heats of solution at constant temperature. With this calorimeter, endothermic or exothermic processes can be studied at temperatures at a given point in the calorimeter constant to ±0.0002 C°. Heat effects are compensated by balancing the heat effect of the process taking place in the calorimeter against a variable heater and a constant cooling Peltier device. The calorimeter was tested by measuring the heat of ionization of water and the heat of dilution of aqueous HClO4 solutions. For these systems heats were measured to an accuracy of ±0.02 cal.