Lithium in drinking water and suicide mortality: interplay with lithium prescriptions

Background Little is known about the effects of lithium intake through drinking water on suicide. This intake originates either from natural rock and soil elution and/or accumulation of lithium-based pharmaceuticals in ground water. Aims To examine the interplay between natural lithium in drinking water, prescribed lithium-based pharmaceuticals and suicide in Austria. Method Spatial Bayesian regressions for males, females and pooled suicide mortality rates were estimated. Results Although the expected inverse association between lithium levels in drinking water and suicide mortality was confirmed for males and for total suicide rates, the relationship for females was not significant. The models do not indicate that lithium from prescriptions, assumed to accumulate in drinking water, is related to suicide risk patterns either as an individual effect or as a moderator of lithium levels in drinking water. Gender-specific differences in risk factors and local risk hot spots are confirmed. Conclusions The findings do not support the hypotheses that lithium prescriptions have measureable protective effects on suicide or that they interact with lithium in drinking water.

[1]  徐晶（译）.  基因科学与亲子鉴定——国际流行病与公众健康杂志J Epidemiol Community Health , 2005 .

[2]  N. Praschak-Rieder,et al.  Lithium in drinking water and suicide mortality , 2011, British Journal of Psychiatry.

[3]  Duncan Lee,et al.  A comparison of conditional autoregressive models used in Bayesian disease mapping. , 2011, Spatial and spatio-temporal epidemiology.

[4]  A. Dietrich,et al.  Age-associated variation in sensory perception of iron in drinking water and the potential for overexposure in the human population. , 2011, Environmental science & technology.

[5]  E. Benito-Peña,et al.  Multiresidue determination of ultratrace levels of fluoroquinolone antimicrobials in drinking and aquaculture water samples by automated online molecularly imprinted solid phase extraction and liquid chromatography. , 2011, Analytical chemistry.

[6]  S. Chaturvedi,et al.  Lithium in drinking water and food, and risk of suicide. , 2009, The British journal of psychiatry : the journal of mental science.

[7]  U. Lewitzka,et al.  Lithium Reduces Pathological Aggression and Suicidality: A Mini-Review , 2010, Neuropsychobiology.

[8]  A. Memon,et al.  Lithium in drinking water and suicide rates across the East of England , 2011, British Journal of Psychiatry.

[9]  B. Palm,et al.  High-level exposure to lithium, boron, cesium, and arsenic via drinking water in the Andes of northern Argentina. , 2010, Environmental science & technology.

[10]  E. C. Harris,et al.  Suicide as an outcome for mental disorders , 1997, British Journal of Psychiatry.

[11]  Marco Helbich,et al.  Geospatial examination of lithium in drinking water and suicide mortality , 2012, International Journal of Health Geographics.

[12]  Union Européenne,et al.  Hip and Knee Replacement , 2021, Current Orthopaedic Practice.

[13]  M. Voracek,et al.  Influence of psychotherapist density and antidepressant sales on suicide rates , 2009, Acta psychiatrica Scandinavica.

[14]  O. Giotakos,et al.  Lithium in the Public Water Supply and Suicide Mortality in Greece , 2013, Biological Trace Element Research.

[15]  G. Schrauzer,et al.  Lithium in drinking water and the incidences of crimes, suicides, and arrests related to drug addictions , 1990, Biological Trace Element Research.

[16]  Robert D Gibbons,et al.  The relationship between antidepressant medication use and rate of suicide. , 2005, Archives of general psychiatry.

[17]  T. Bschor,et al.  Lithium in the public water supply and suicide mortality in Texas. , 2013, Journal of psychiatric research.

[18]  M. Leitner,et al.  Does altitude moderate the impact of lithium on suicide? A spatial analysis of Austria. , 2013, Geospatial health.

[19]  K. Belitz,et al.  Occurrence and concentrations of pharmaceutical compounds in groundwater used for public drinking-water supply in California. , 2011, The Science of the total environment.

[20]  W. Laan,et al.  Psychosis and suicide risk by ethnic origin and history of migration in the Netherlands , 2012, Schizophrenia Research.

[21]  D. Kolpin,et al.  A national reconnaissance of pharmaceuticals and other organic wastewater contaminants in the United States--I) groundwater. , 2008, The Science of the total environment.

[22]  Union Européenne,et al.  Health at a Glance: Europe 2020 , 2020, Health at a Glance: Europe.

[23]  Hong-Ying Hu,et al.  Monitoring and evaluation of antibiotic-resistant bacteria at a municipal wastewater treatment plant in China. , 2012, Environment international.

[24]  F. Goodwin,et al.  Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review. , 2006, Bipolar disorders.

[25]  S. Kleywegt,et al.  Pharmaceuticals, hormones and bisphenol A in untreated source and finished drinking water in Ontario, Canada--occurrence and treatment efficiency. , 2011, The Science of the total environment.

[26]  Bill Bynum,et al.  Lancet , 2015, The Lancet.

[27]  J. Geddes,et al.  Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials. , 2005, The American journal of psychiatry.

[28]  G. Nentwig.  Effects of Pharmaceuticals on Aquatic Invertebrates. Part II: The Antidepressant Drug Fluoxetine , 2007, Archives of environmental contamination and toxicology.

[29]  Keith Hawton,et al.  Risk factors for suicide in individuals with depression: a systematic review. , 2013, Journal of affective disorders.

[30]  M. Bellanger,et al.  Might the decrease in the suicide rates in France be due to regional prevention programmes? , 2007, Social science & medicine.

[31]  T. Terao,et al.  Lithium in Tap Water and Suicide Mortality in Japan , 2013, International journal of environmental research and public health.

[32]  J. Sterne,et al.  Changes in the geography of suicide in young men: England and Wales 1981–2005 , 2010, Journal of Epidemiology & Community Health.

[33]  T. Bschor.  Lithium in the Treatment of Major Depressive Disorder , 2014, Drugs.

[34]  Z. Rihmer,et al.  Investigation of the marked and long-standing spatial inhomogeneity of the Hungarian suicide rate: a spatial regression approach. , 2014, Journal of affective disorders.

[35]  P. Andersen,et al.  Suicide risk in patients treated with lithium. , 2005, Archives of general psychiatry.

[36]  T. Terao,et al.  Lithium levels in drinking water and risk of suicide , 2009, British Journal of Psychiatry.