论文信息 - A marine isonitrile produced by Indonesian marine sponge of Petrosia sp. as an inhibitor of the human pancreatic cancer cells

A marine isonitrile produced by Indonesian marine sponge of Petrosia sp. as an inhibitor of the human pancreatic cancer cells

The study of search the bioactive compound from Indonesian Marine Sponge Petrosia sp. has been conducted on February 2019. The bioactive compound isolated based on bioassay-guided separation with several steps of chromatography. The compound known as C16H25NS determined by lCmS-ESI with molecular weight [M+H]+263.42m/z. The FTIR data showed that the functionality as hydrocarbon skeletone of alkane and isonitrile at 2982.58 cm−1 and 2115 cm−1, respectively. Furthermore, the NMR data confirm that the active compound knowns as 4-amorphene-10- isothiocyanate. The cytotoxic data indicate that the bioactive compound has activity against Panc-1 cell [IC50 = 0.1 μg / mL].The secondary metabolite from Indonesian marine sponge of Petrosia sp. has potential activity against human pancreatic cancer cells.

[1] Liang Zhang,et al. Enantiomerically enriched tris(boronates): readily accessible conjunctive reagents for asymmetric synthesis. , 2014, Journal of the American Chemical Society.

[2] Yingfen Qin,et al. A novel approach for enriching cancer stem cells from the human SW-13 adrenocortical carcinoma cell line. , 2014, Anticancer research.

[3] S. Rokutanda,et al. Isolation and characterization of cancer stem-like side population cells in human oral cancer cells. , 2011, Oral oncology.

[4] F. Coutrot,et al. Very contracted to extended co-conformations with or without oscillations in two- and three-station [c2]daisy chains. , 2010, The Journal of organic chemistry.

[5] G. Gallick,et al. Development and Characterization of Gemcitabine-Resistant Pancreatic Tumor Cells , 2007, Annals of Surgical Oncology.

[6] E. Fukushi,et al. Nakinadine A, a Novel Bis-pyridine Alkaloid with a β-Amino Acid Moiety from Sponge Amphimedon sp. , 2007 .

[7] M. Caraglia,et al. Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. , 2007, Biochimica et biophysica acta.

[8] Y. Morimoto,et al. Total synthesis and assignment of the double-bond position and absolute configuration of (-)-pyrinodemin A. , 2003, Organic letters.

[9] A. Patwardhan,et al. Efficient synthesis of 40- and 48-membered tetraether macrocyclic bisphosphocholines. , 1999, Organic letters.