Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples

AbstractBasic information on the association between lifestyle factors and candidate genes is valuable for genetic-environmental study. We screened the association of habitual smoking or drinking with polymorphism in 40 candidate genes for a total of 153 single nucleotide polymorphisms (SNPs) using a sample of 339 middle-aged, randomly selected Japanese men. Smoking and drinking statuses were elicited during questionnaire-based interviews. Genes were selected based on their possible involvement in genetic-environmental, life-style interactions and constitute the genes expressing xenobiotic metabolism enzymes, DNA repair enzymes, and other stress-related proteins. The P values of odds ratios to habitual smoking for CYP17A1, ESR1, EPHX1, GSTT2, ALDH2, NOS2A, OGG1, and SLC6A4 and those of odds ratios to habitual drinking for CYP1B1, ESR1, HSD17B3, GSTM3, COMT, ADH1C, ALDH2, NOS3, and NUDT1 were under 0.05. These variables were included in a stepwise logistic analysis in order to develop a predictive model for smoking or drinking behavior. In the final model, the only significant variables selected for smoking were OGG1, SLC6A4, EPHX1, ESR1, and CYP17A1, and for drinking, ALDH2 and NUDT1. The findings of the present study suggest that polymorphism in associated candidate genes plays a role in the habitual use of tobacco and alcohol among Japanese men.

[1]  C. Harris,et al.  Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology, and human risk assessment. , 1996, Preventive medicine.

[2]  James J Schlesselman.  Case-Control Studies: Design, Conduct, Analysis , 1982 .

[3]  T. Kohno,et al.  Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples , 2003, Journal of Human Genetics.

[4]  N. Hamajima,et al.  Association between the dopamine D2 receptor A2/A2 genotype and smoking behavior in the Japanese. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[5]  T. Arinami,et al.  Association between serotonin transporter gene polymorphism and smoking among Japanese males. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[6]  L. Marchand,et al.  Association of the hOGG 1 Ser 326 Cys Polymorphism with Lung Cancer Risk 1 , 2002 .

[7]  B. Morris,et al.  Association of Ile462Val (Exon 7) polymorphism of cytochrome P450 IA1 with lung cancer in the Asian population: further evidence from a case-control study in Okinawa. , 1998, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[8]  P. Ross,et al.  High level multiplex genotyping by MALDI-TOF mass spectrometry , 1998, Nature Biotechnology.

[9]  R. Tyndale,et al.  Nicotine metabolism defect reduces smoking , 1998, Nature.

[10]  W. Zheng,et al.  Retrospective Cohort Study on Association of Lung Cancer with Pulmonary Tuberculosis , 1992 .

[11]  T. Kawamoto,et al.  Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma , 2003, Journal of Cancer Research and Clinical Oncology.

[12]  T. Omori,et al.  [Alcohol and oropharyngolaryngeal and digestive tract cancer]. , 2001, Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence.

[13]  S. Tsugane,et al.  Cross-sectional Epidemiologic Study for Assessing Cancer Risks at the Population Level , 1992 .

[14]  J. Hewitt,et al.  Common genetic and environmental vulnerability for alcohol and tobacco use in a volunteer sample of older female twins. , 2001, Journal of studies on alcohol.

[15]  S. Higuchi,et al.  Alcohol and aldehyde dehydrogenase genotypes and drinking behavior of Chinese living in Shanghai , 1995, Human Genetics.

[16]  M. Spitz,et al.  D2 dopamine receptor gene polymorphisms among African-Americans and Mexican-Americans: a lung cancer case-control study. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[17]  D. Carmelli,et al.  Genetic influence on smoking--a study of male twins. , 1992, The New England journal of medicine.

[18]  C. Ulrich,et al.  Polymorphisms in DNA repair genes and associations with cancer risk. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[19]  D. Comings,et al.  Potential role of the estrogen receptor gene (ESR1) in anxiety , 1999, Molecular Psychiatry.

[20]  P. Shields,et al.  The role of the serotonin transporter gene in cigarette smoking. , 1998, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[21]  W. Iacono,et al.  Origins and consequences of age at first drink. II. Familial risk and heritability. , 2001, Alcoholism, clinical and experimental research.

[22]  C. Eriksson,et al.  The role of acetaldehyde in the actions of alcohol (update 2000). , 2001, Alcoholism, clinical and experimental research.

[23]  L. M. Srivastava,et al.  Distribution of ADH2 and ALDH2 genotypes in different populations , 2004, Human Genetics.

[24]  N. Martin,et al.  The inheritance of alcohol consumption patterns in a general population twin sample: II. Determinants of consumption frequency and quantity consumed. , 1991, Journal of studies on alcohol.

[25]  D. Murphy,et al.  A genetic association for cigarette smoking behavior. , 1999, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[26]  Eriksson Cjp.  The role of acetaldehyde in the actions of alcohol , 2001 .

[27]  E. Bowman,et al.  Dopamine D4 receptors and the risk of cigarette smoking in African-Americans and Caucasians. , 1998, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.