Hair cortisol and childhood trauma predict psychological therapy response in depression and anxiety disorders

Around 30–50% of patients with depression and anxiety disorders fail to respond to standard psychological therapy. Given that cortisol affects cognition, patients with altered hypothalamic–pituitary–adrenal (HPA) axis functioning may benefit less from such treatments. To investigate this, reliable pretreatment cortisol measures are needed.

[1]  M. Hotopf,et al.  Recurrence of Depression in Relation to History of Childhood Trauma and Hair Cortisol Concentration in a Community-Based Sample , 2019, Neuropsychobiology.

[2]  Kia-Chong Chua,et al.  Short‐term and long‐term measures of cortisol in saliva and hair in atypical and non‐atypical depression , 2018, Acta psychiatrica Scandinavica.

[3]  Kia-Chong Chua,et al.  Elevated fingernail cortisol levels in major depressive episodes , 2018, Psychoneuroendocrinology.

[4]  A. Cleare,et al.  Hypothalamic-pituitary-adrenal (HPA) axis functioning as predictor of antidepressant response–Meta-analysis , 2017, Neuroscience & Biobehavioral Reviews.

[5]  I. Gotlib,et al.  Investigating the nature of co-occurring depression and anxiety: Comparing diagnostic and dimensional research approaches. , 2017, Journal of affective disorders.

[6]  A. Cleare,et al.  Cortisol as a predictor of psychological therapy response in anxiety disorders-Systematic review and meta-analysis. , 2017, Journal of anxiety disorders.

[7]  A. Cleare,et al.  Cortisol as a predictor of psychological therapy response in depressive disorders: Systematic review and meta-analysis , 2017, British Journal of Psychiatry.

[8]  M. Hotopf,et al.  Sociodemographic, lifestyle, and psychosocial determinants of hair cortisol in a South London community sample , 2016, Psychoneuroendocrinology.

[9]  T. Stalder,et al.  Hair cortisol concentrations and cortisol stress reactivity in generalized anxiety disorder, major depression and their comorbidity. , 2017, Journal of psychiatric research.

[10]  L. Schwabe,et al.  Stress, glucocorticoids and memory: implications for treating fear-related disorders , 2016, Nature Reviews Neuroscience.

[11]  S. Short,et al.  Correspondence between hair cortisol concentrations and 30-day integrated daily salivary and weekly urinary cortisol measures , 2016, Psychoneuroendocrinology.

[12]  M. Hotopf,et al.  Clinical characteristics of patients assessed within an Improving Access to Psychological Therapies (IAPT) service: results from a naturalistic cohort study (Predicting Outcome Following Psychological Therapy; PROMPT) , 2016, BMC Psychiatry.

[13]  Tobias Stalder,et al.  Hair cortisol concentrations and cortisol stress reactivity predict PTSD symptom increase after trauma exposure during military deployment , 2015, Psychoneuroendocrinology.

[14]  M. Thase.  Using biomarkers to predict treatment response in major depressive disorder: evidence from past and present studies , 2014, Dialogues in clinical neuroscience.

[15]  M. Hotopf,et al.  Predicting outcome following psychological therapy in IAPT (PROMPT): a naturalistic project protocol , 2014, BMC Psychiatry.

[16]  G. Andersson,et al.  The effects of psychotherapies for major depression in adults on remission, recovery and improvement: a meta-analysis. , 2014, Journal of affective disorders.

[17]  A. Schatzberg,et al.  Pretreatment cortisol levels predict posttreatment outcomes among older adults with depression in cognitive behavioral therapy , 2013, Psychiatry Research.

[18]  C. Kirschbaum,et al.  Association Between Childhood Trauma and Low Hair Cortisol in Depressed Patients and Healthy Control Subjects , 2013, Biological Psychiatry.

[19]  Kathryn R. Cullen,et al.  A pilot study of depressed adolescents' cortisol patterns during parent-adolescent conflict and response to interpersonal psychotherapy (IPT-A). , 2013, Journal of affective disorders.

[20]  A. Vincent,et al.  Lifetime Adversity Leads to Blunted Stress Axis Reactivity: Studies from the Oklahoma Family Health Patterns Project , 2012, Biological Psychiatry.

[21]  A. Danese,et al.  Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. , 2011, The American journal of psychiatry.

[22]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[23]  D. Clark,et al.  Implementing NICE guidelines for the psychological treatment of depression and anxiety disorders: The IAPT experience , 2011, International review of psychiatry.

[24]  M. Thase.  Treatment-resistant depression: prevalence, risk factors, and treatment strategies. , 2011, The Journal of clinical psychiatry.

[25]  C. Kirschbaum,et al.  Decreased hair cortisol concentrations in generalised anxiety disorder , 2011, Psychiatry Research.

[26]  O. Wolf,et al.  Cognitive correlates of hypothalamic–pituitary–adrenal axis in major depression , 2011, Expert review of endocrinology & metabolism.

[27]  R. Murray,et al.  Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment , 2010, Schizophrenia Research.

[28]  Michael J Meaney,et al.  Epigenetics and the biological definition of gene x environment interactions. , 2010, Child development.

[29]  L. Price,et al.  Dex/CRH test cortisol response in outpatients with major depression and matched healthy controls , 2009, Psychoneuroendocrinology.

[30]  L. Price,et al.  Effect of Childhood Emotional Abuse and Age on Cortisol Responsivity in Adulthood , 2009, Biological Psychiatry.

[31]  S. Lautenbacher,et al.  Mid-term effects of serial sleep deprivation therapy implemented in cognitive-behavioral treatment on the neuroendocrine response to clomipramine in patients with major depression. , 2009, Journal of psychiatric research.

[32]  C. Kirschbaum,et al.  Hair as a retrospective calendar of cortisol production—Increased cortisol incorporation into hair in the third trimester of pregnancy , 2009, Psychoneuroendocrinology.

[33]  A. Beekman,et al.  [Treatment for chronic depression: cognitive behavioral analysis system of psychotherapy (CBASP)]. , 2009, Tijdschrift voor psychiatrie.

[34]  C. Nemeroff,et al.  The link between childhood trauma and depression: Insights from HPA axis studies in humans , 2008, Psychoneuroendocrinology.

[35]  Jasper A. J. Smits,et al.  DISORDERS : A META-ANALYSIS OF RANDOMIZED PLACEBO-CONTROLLED TRIALS , 2008 .

[36]  L. Price,et al.  Decreased Adrenocorticotropic Hormone and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment , 2007, Biological Psychiatry.

[37]  R. Spitzer,et al.  The PHQ-9 , 2001, Journal of General Internal Medicine.

[38]  A. Bystritsky.  Treatment-resistant anxiety disorders , 2006, Molecular Psychiatry.

[39]  B. Löwe,et al.  A brief measure for assessing generalized anxiety disorder: the GAD-7. , 2006, Archives of internal medicine.

[40]  B. Ellis,et al.  Printed in the United States of America DOI: 10.10170S0954579405050145 , 2022 .

[41]  U. Ehlert,et al.  Mind over matter , 2005 .

[42]  B. Rothbaum,et al.  Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[43]  McCullough,et al.  Treatment for chronic depression: Cognitive Behavioral Analysis System of Psychotherapy (CBASP). , 2003 .

[44]  M. Newcomb,et al.  Development and validation of a brief screening version of the Childhood Trauma Questionnaire. , 2003, Child abuse & neglect.

[45]  R. Bonsall,et al.  Altered Pituitary-Adrenal Axis Responses to Provocative Challenge Tests in Adult Survivors of Childhood Abuse , 2001 .

[46]  R. Bonsall,et al.  Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. , 2000, JAMA.

[47]  D. Bernstein,et al.  Childhood Trauma Questionnaire: A retrospective self-report , 1998 .

[48]  D. Sheehan,et al.  The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. , 1998, The Journal of clinical psychiatry.

[49]  M. Thase,et al.  Hypothalamic-pituitary-adrenocortical activity and response to cognitive behavior therapy in unmedicated, hospitalized depressed patients. , 1996, American Journal of Psychiatry.

[50]  M. Thase,et al.  Psychobiological correlates of poor response to cognitive behavior therapy: potential indications for antidepressant pharmacotherapy. , 1993, Psychopharmacology bulletin.

[51]  N. Jacobson,et al.  Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. , 1991, Journal of consulting and clinical psychology.