Title Restoration of outer segments of foveal photoreceptors after resolution of central serous chorioretinopathy

Purpose: To study morphologically and functionally the prognosis of damaged outer segments of the foveal photoreceptor layer in eyes with resolved central serous chorioretinopathy (CSC). Methods: We studied retrospectively the medical records of 70 patients (74 eyes) 5 with resolved CSC. Optical coherence tomography was used to detect the junctions between inner and outer segments of the photoreceptors (IS/OS) as a hallmark of integrity of the outer photoreceptor layer. Results: In 53 eyes (71.6%), the IS/OS line was detected clearly beneath the fovea immediately after resolution of the retinal detachment, with good visual acuity (VA). 10 In the remaining 21 eyes (28.4%), however, the foveal IS/OS line could not be detected shortly after resolution of CSC, and VA was variable at that time, ranging from 0.1 to 1.5 (median, 0.9). In 4 of 15 eyes with follow-up examinations, the foveal IS/OS line was not detected throughout follow-up, and vision in these eyes remained poor. However, nine eyes showed recovery of the foveal IS/OS line during follow-up, 15 and these eyes showed substantial visual recovery. Conclusions: Immediately after resolution of active CSC, even though the IS/OS line is not detected beneath the fovea, it often shows restoration over time, with visual recovery. Restoration of Photoreceptors in CSC. Ojima Y, et al. Page 3