The Simultaneous Presence of Anti‐I and Anti‐i in Sera 1

The specificity of antibodies that detect the antigens I, i, IT, IH (10), IA, IB, iH (iO), and IP1, [23, 10, 21, 11, 12, 3, 16, 17, 2, 5, 18, 22, 4, 20, 6, 7] can be established with little difficulty. There remain, however, many cold agglutinins that do not have specificity directed against any one of these antigens; this paper describes studies on 22 such sera, 3 of which react equally with I and i cells (regardless of ABO group) and 19 of which have anti‐I specificity but react with significant strength with i cells as compared to a ‘standard’ anti‐I. Absorption and elution experiments with selected erythrocytes show that all 22 sera contain separable anti‐I and anti‐i.

[1]  P. Issitt,et al.  Useful Modifications and Variations of Technics in Work on I System Antibodies 1 , 1968, Vox sanguinis.

[2]  P. Issitt,et al.  Sj, a New Antigen in the MN System, and Further Studies on Tm 1 , 1968, Vox sanguinis.

[3]  P. Issitt,et al.  Anti‐IP1: Antibodies that Show an Association Between the I and P Blood Group Systems 1 , 1968 .

[4]  J. Yarbro,et al.  Ogata Phenomenon Explaining the Unusual Specificity in Eluates from Coombs Positive Cells Sensitized by Autogenous Anti‐I 1 , 1967 .

[5]  P. Issitt,et al.  Anti‐IB, an Expected “New” Antibody Detecting a Joint Product of the I and B Genes 1 , 1967, Vox sanguinis.

[6]  P. Issitt.  I blood group system and its relation to other blood group systems. , 1967, The Journal of medical laboratory technology.

[7]  P. Booth,et al.  Anti‐IT: A New Antibody of the I Blood‐Group System Occurring in Certain Melanesian Sera , 1966, British journal of haematology.

[8]  A. S. Wiener,et al.  The blood factors I and i in primates including man, and in lower species. , 1965, American journal of physical anthropology.

[9]  M. Mcginniss,et al.  Differences Between Anti‐H and Anti‐OI Red Cell Antibodies , 1965, Vox Sanguinis.

[10]  D. Voak.  ANTI-HI, A NEW COLD ANTIBODY OF THE H.O.I. COMPLEX: A PRELIMINARY REPORT. , 2009, Scandinavian journal of haematology.

[11]  H. Bhatia,et al.  Observations on the 0 Antigen * , 1964 .

[12]  R. Rosenfield,et al.  Erythrocytic Antigenic Determinants Characteristic of H, I in the Presence of H [IH], or H in the Absence of i [H(‐i)]* , 1964, Vox sanguinis.

[13]  E. Gold.  Observations on the Specificity of Anti‐O and Anti‐A1 Sera , 1964, Vox sanguinis.

[14]  E. Gold.  Observations on the Specificity of Anti-0 and Anti-A(1) Sera , 1964 .

[15]  T. Matuhasi,et al.  FURTHER OBSERVATIONS ON THE PROBLEMS OF SPECIFIC AND CROSS REACTIVITY OF BLOOD GROUP ANTIBODIES. , 1964, Bibliotheca haematologica.

[16]  P. L. Mollison,et al.  Blood Groups in Man , 1962 .

[17]  T. Matuhasi,et al.  Problems of specific and cross reactivity of blood group antibodies. , 1962, Bibliotheca haematologica.

[18]  W. Marsh,et al.  Anti‐i: A Cold Antibody Defining the li Relationship in Human Red Cells , 1961, British journal of haematology.

[19]  W. Marsh,et al.  Anti-i : a New Cold Antibody , 1960, Nature.

[20]  P. Tippett,et al.  Further Studies of the I Antigen and Antibody , 1960 .

[21]  P. Tippett,et al.  The I Antigen and Antibody , 1960, Vox sanguinis.

[22]  A. S. Wiener,et al.  Type-specific cold auto-antibodies as a cause of acquired hemolytic anemia and hemolytic transfusion reactions: biologic test with bovine red cells. , 1956, Annals of internal medicine.