High glucose induced human breast cancer cell MCF-7 viability , migration and invasion via the expression of AKT , MAPKs and STAT 3

High glucose induces human breast cancer cell viability, migration and invasion in vitro and in vivo. However, the mechanism of high glucose induces human breast cancer cell viability, migration and invasion remains poorly understood. In our study, we investigate the effects of high glucose induces MCF-7 human breast cancer cell viability, migration and invasion in vitro experiments. High glucose induces activation of cell viability, migration and invasion in a timeand concentration-dependent manner. The mechanism reveals that high glucose significantly increases the phosphorylation of AKT, ERK1/2 and STAT3 and inhibits the phosphorylation of p38 MAPK. These results suggest that high glucose induces human breast cancer cell MCF-7 viability, migration and invasion via the expression of AKT, MAPKs and STAT3.

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