Resveratrol and related stilbenes: their anti-aging and anti-angiogenic properties.

[1]  Qing-Feng Zhang,et al.  Chemical constituents comparison between Rhizoma Smilacis Glabrae and Rhizoma Smilacis Chinae by HPLC-DAD-MS/MS , 2013, Natural product research.

[2]  T. Richard,et al.  Isorhapontigenin: a novel bioactive stilbene from wine grapes. , 2012, Food chemistry.

[3]  J. M. Soriano,et al.  A preliminary study of presence of resveratrol in skins and pulps of European and Japanese plum cultivars. , 2012, Journal of the science of food and agriculture.

[4]  D. Wolters,et al.  A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol , 2012, PloS one.

[5]  M. Savio,et al.  The resveratrol analog 4,4'-dihydroxy-trans-stilbene suppresses transformation in normal mouse fibroblasts and inhibits proliferation and invasion of human breast cancer cells. , 2012, Carcinogenesis.

[6]  R. Cela,et al.  Determination of hydroxylated stilbenes in wine by dispersive liquid-liquid microextraction followed by gas chromatography mass spectrometry. , 2012, Journal of chromatography. A.

[7]  J. Dyck,et al.  Resveratrol as a calorie restriction mimetic: therapeutic implications. , 2012, Trends in cell biology.

[8]  Rui Yang,et al.  Effects of resveratrol on vascular endothelial growth factor expression in osteosarcoma cells and cell proliferation. , 2012, Oncology letters.

[9]  D. Kletsas,et al.  Grape stem extracts: Polyphenolic content and assessment of their in vitro antioxidant properties , 2012 .

[10]  K. Nishio,et al.  Aza-derivatives of resveratrol are potent macrophage migration inhibitory factor inhibitors , 2012, Investigational New Drugs.

[11]  C. Yao,et al.  A new resveratrol trimer derivative from Gnetum brunonianum , 2012, Journal of Asian natural products research.

[12]  Min Zhang,et al.  The Chinese Herb Isolate Isorhapontigenin Induces Apoptosis in Human Cancer Cells by Down-regulating Overexpression of Antiapoptotic Protein XIAP* , 2012, The Journal of Biological Chemistry.

[13]  Sun-Hee Kim,et al.  Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis. , 2012, Biochemical pharmacology.

[14]  D. Sinclair,et al.  The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction , 2012, Aging.

[15]  M. Palma,et al.  Ultrasound assisted extraction of phenolic compounds from grapes. , 2012, Analytica chimica acta.

[16]  D. Ribeiro,et al.  Use of grape polyphenols for promoting human health: a review of patents. , 2012, Recent patents on food, nutrition & agriculture.

[17]  F. Aujard,et al.  Effects of Chronic Calorie Restriction or Dietary Resveratrol Supplementation on Insulin Sensitivity Markers in a Primate, Microcebus murinus , 2012, PloS one.

[18]  M. Wierzchowski,et al.  Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8/CXCL8 , 2012, Angiogenesis.

[19]  L. Mespouille,et al.  Targeted extraction of active compounds from natural products by molecularly imprinted polymers , 2012 .

[20]  D. Borderie,et al.  Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and *NO bioavailability: Potential benefits to cardiovascular diseases. , 2012, Biochimie.

[21]  M. Higes,et al.  Liquid Chromatographic Determination of Resveratrol and Piceid Isomers in Honey , 2012, Food Analytical Methods.

[22]  E. Gerhardt,et al.  Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice , 2011, PloS one.

[23]  Soo-Jin Jeong,et al.  Are there new therapeutic options for treating lung cancer based on herbal medicines and their metabolites? , 2011, Journal of ethnopharmacology.

[24]  J. Estrela,et al.  Natural polyphenols in cancer therapy , 2011, Critical reviews in clinical laboratory sciences.

[25]  R. de Cabo,et al.  The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster , 2011, AGE.

[26]  Dennis K. Taylor,et al.  Microwave-assistance provides very rapid and efficient extraction of grape seed polyphenols. , 2011, Food chemistry.

[27]  Y. Yamori,et al.  Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract suppresses multiple angiogenesis-related endothelial cell functions and tumor angiogenesis. , 2011, Molecular nutrition & food research.

[28]  Lin Chen,et al.  SIRT1 is required for long-term growth of human mesenchymal stem cells , 2011, Journal of Molecular Medicine.

[29]  Wenqing Cai,et al.  3,4,4′-Trihydroxy-trans-stilbene, an analogue of resveratrol, is a potent antioxidant and cytotoxic agent , 2011, Free radical research.

[30]  Jiekai Chen,et al.  Rapamycin and other longevity‐promoting compounds enhance the generation of mouse induced pluripotent stem cells , 2011, Aging cell.

[31]  J. Câmara,et al.  New method for determination of (E)-resveratrol in wine based on microextraction using packed sorbent and ultra-performance liquid chromatography. , 2011, Journal of separation science.

[32]  P. Zhang,et al.  Comparative effects of short-term and long-term insulin-induced hypoglycemia on glucose production in the perfused livers of weaned rats , 2011, Pharmacological reports : PR.

[33]  Qingsong Liu,et al.  The controversial links among calorie restriction, SIRT1, and resveratrol. , 2011, Free radical biology & medicine.

[34]  G. Mazza,et al.  Simultaneous analysis of serotonin, melatonin, piceid and resveratrol in fruits using liquid chromatography tandem mass spectrometry. , 2011, Journal of chromatography. A.

[35]  Soo-Jin Jeong,et al.  Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells. , 2011, Biological & pharmaceutical bulletin.

[36]  U. Schilde,et al.  Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate) , 2011, Chemistry Central journal.

[37]  T. Hofmann,et al.  Quantitation of resveratrol in red wines by means of stable isotope dilution analysis-ultra-performance liquid chromatography-Quan-time-of-flight mass spectrometry and cross validation. , 2011, Analytical chemistry.

[38]  M. Febbraio,et al.  Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1 , 2011, Molecular and Cellular Endocrinology.

[39]  A. Howard,et al.  UPLC and Spectrophotometric Analysis of Polyphenols in Wines Available in the Polish Market , 2011 .

[40]  R. de Cabo,et al.  Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. , 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

[41]  Raj Kumar,et al.  Resveratrol in cancer management: where are we and where we go from here? , 2011, Annals of the New York Academy of Sciences.

[42]  F. B. Davis,et al.  Resveratrol and apoptosis , 2011, Annals of the New York Academy of Sciences.

[43]  M. Mattson,et al.  Resveratrol commonly displays hormesis: Occurrence and biomedical significance , 2010, Human & experimental toxicology.

[44]  K. Kang,et al.  Amurensin G, a Potent Natural SIRT1 Inhibitor, Rescues Doxorubicin Responsiveness via Down-Regulation of Multidrug Resistance 1 , 2010, Molecular Pharmacology.

[45]  Qiao Liu,et al.  Resveratrol modulates angiogenesis through the GSK3β/β-catenin/TCF-dependent pathway in human endothelial cells. , 2010, Biochemical pharmacology.

[46]  Davy Guillarme,et al.  High throughput qualitative analysis of polyphenols in tea samples by ultra-high pressure liquid chromatography coupled to UV and mass spectrometry detectors. , 2010, Journal of chromatography. A.

[47]  J. Fruehauf,et al.  Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture , 2010, Angiogenesis.

[48]  D. Das,et al.  Dose-Dependency of Resveratrol in Providing Health Benefits , 2010, Dose-response : a publication of International Hormesis Society.

[49]  T. Hsieh,et al.  Resveratrol: Biological and pharmaceutical properties as anticancer molecule , 2010, BioFactors.

[50]  S. Fulda.  Resveratrol and derivatives for the prevention and treatment of cancer. , 2010, Drug discovery today.

[51]  G. Kelly.  A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1. , 2010, Alternative medicine review : a journal of clinical therapeutic.

[52]  C. Bronner,et al.  Intake of grape‐derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[53]  J. Pezzuto,et al.  Pleiotropic mechanisms facilitated by resveratrol and its metabolites. , 2010, The Biochemical journal.

[54]  R. Cela,et al.  Mixed-mode solid-phase extraction followed by acetylation and gas chromatography mass spectrometry for the reliable determination of trans-resveratrol in wine samples. , 2010, Analytica chimica acta.

[55]  H. Pehamberger,et al.  3,3',4,4',5,5'-hexahydroxystilbene impairs melanoma progression in a metastatic mouse model. , 2010, The Journal of investigative dermatology.

[56]  G. Tucker,et al.  Physiological concentrations of dietary polyphenols regulate vascular endothelial cell expression of genes important in cardiovascular health. , 2010, The British journal of nutrition.

[57]  S. Shankar,et al.  FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol , 2010, Molecular and Cellular Biochemistry.

[58]  T. Szekeres,et al.  Resveratrol and Resveratrol Analogues—Structure—Activity Relationship , 2010, Pharmaceutical Research.

[59]  P. Kovacic,et al.  Multifaceted approach to resveratrol bioactivity: Focus on antioxidant action, cell signaling and safety. , 2010, Oxidative medicine and cellular longevity.

[60]  T. Szekeres,et al.  Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells , 2009, Investigational New Drugs.

[61]  A. Devery,et al.  Synthesis, structural characterisation and biological evaluation of fluorinated analogues of resveratrol. , 2009, Bioorganic & medicinal chemistry.

[62]  H. Lou,et al.  Natural stilbenes: an overview. , 2009, Natural product reports.

[63]  David R Bickers,et al.  Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. , 2009, Archives of biochemistry and biophysics.

[64]  Jane-ling Wang,et al.  The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly , 2009, Experimental Gerontology.

[65]  A. Bishayee.  Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials , 2009, Cancer Prevention Research.

[66]  M. C. García-Parrilla,et al.  Wine, Resveratrol and Health: A Review , 2009, Natural product communications.

[67]  M. Slevin,et al.  Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis , 2009, BMC Cell Biology.

[68]  J. K. Kundu,et al.  Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. , 2008, Cancer letters.

[69]  Y. Kimura,et al.  Antitumor activities of synthetic and natural stilbenes through antiangiogenic action , 2008, Cancer science.

[70]  Chibuike C. Udenigwe,et al.  Potential of resveratrol in anticancer and anti-inflammatory therapy. , 2008, Nutrition reviews.

[71]  D. Corradini,et al.  Identification and Quantification of Trans-Resveratrol in Dietary Supplements by a Rapid and Straightforward RP-HPLC Method , 2008 .

[72]  D. Allison,et al.  A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice , 2008, PloS one.

[73]  W. Dubiel,et al.  Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. , 2008, Mini reviews in medicinal chemistry.

[74]  M. Hernández-Córdoba,et al.  A comparison of solid-phase microextraction and stir bar sorptive extraction coupled to liquid chromatography for the rapid analysis of resveratrol isomers in wines, musts and fruit juices. , 2008, Analytica chimica acta.

[75]  Andrew D. Steele,et al.  SIRT1 transgenic mice show phenotypes resembling calorie restriction , 2007, Aging cell.

[76]  Amy V. Lynch,et al.  Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes , 2007, Nature.

[77]  T. Szekeres,et al.  N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: synergistic antitumor activity with arabinofuranosylcytosine. , 2007, International journal of oncology.

[78]  I. Villegas,et al.  Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. , 2007, Biochemical Society transactions.

[79]  B. Morris,et al.  The Effect of Resveratrol on a Cell Model of Human Aging , 2007, Annals of the New York Academy of Sciences.

[80]  L. Partridge,et al.  Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans , 2007, Mechanisms of Ageing and Development.

[81]  Walter Jaeger,et al.  'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. , 2007, Bioorganic & medicinal chemistry.

[82]  L. Pirola,et al.  Resveratrol is a class IA phosphoinositide 3-kinase inhibitor. , 2007, The Biochemical journal.

[83]  T. Hagemann,et al.  Ovarian cancer cell–derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis , 2007, Molecular Cancer Therapeutics.

[84]  B. Halliwell,et al.  Evidence for a Trade‐Off between Survival and Fitness Caused by Resveratrol Treatment of Caenorhabditis elegans , 2007, Annals of the New York Academy of Sciences.

[85]  Yun Chen,et al.  Pro- and Anti-angiogenesis Effects of Resveratrol , 2007 .

[86]  D. Kouretas,et al.  Inhibition of ozone-induced SP-A oxidation by plant polyphenols , 2007, Free radical research.

[87]  P. Puigserver,et al.  Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.

[88]  P. Puigserver,et al.  Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.

[89]  Joseph A. Baur,et al.  Therapeutic potential of resveratrol: the in vivo evidence , 2006, Nature Reviews Drug Discovery.

[90]  Antonino Cattaneo,et al.  Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate , 2006, Current Biology.

[91]  J. Becquemin,et al.  Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis. , 2005, Journal of vascular surgery.

[92]  N. Maulik,et al.  Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor. , 2005, Journal of molecular and cellular cardiology.

[93]  Izumi Horikawa,et al.  Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. , 2005, Molecular biology of the cell.

[94]  R. Ghidoni,et al.  Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. , 2005, The Journal of nutritional biochemistry.

[95]  N. Latruffe,et al.  Resveratrol: preventing properties against vascular alterations and ageing. , 2005, Molecular nutrition & food research.

[96]  V. Somoza,et al.  Metabolism and bioavailability of trans-resveratrol. , 2005, Molecular nutrition & food research.

[97]  I. Villegas,et al.  Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. , 2005, Molecular nutrition & food research.

[98]  Brian C. Smith,et al.  Mechanism of Human SIRT1 Activation by Resveratrol* , 2005, Journal of Biological Chemistry.

[99]  S. Fields,et al.  Substrate-specific Activation of Sirtuins by Resveratrol* , 2005, Journal of Biological Chemistry.

[100]  C. la Vecchia,et al.  Resveratrol and breast cancer risk , 2005, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[101]  C. Klinge,et al.  Resveratrol and Estradiol Rapidly Activate MAPK Signaling through Estrogen Receptors α and β in Endothelial Cells* , 2005, Journal of Biological Chemistry.

[102]  G. Ecker,et al.  Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. , 2004, Bioorganic & medicinal chemistry.

[103]  S. Helfand,et al.  An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[104]  J. Wood,et al.  Sirtuin activators mimic caloric restriction and delay ageing in metazoans , 2004, Nature.

[105]  Xianglin Shi,et al.  trans-3,4,5′-Trihydroxystibene Inhibits Hypoxia-Inducible Factor 1α and Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells , 2004, Clinical Cancer Research.

[106]  Namjin Chung,et al.  Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ , 2004, Nature.

[107]  S. Ho.  Estrogens and anti‐estrogens: Key mediators of prostate carcinogenesis and new therapeutic candidates , 2004, Journal of cellular biochemistry.

[108]  P. Kittakoop,et al.  Lakoochins A and B, new antimycobacterial stilbene derivatives from Artocarpus lakoocha. , 2004, Journal of natural products.

[109]  T. Cheng,et al.  Inhibition of Cyclic Strain-Induced Endothelin-1 Gene Expression by Resveratrol , 2003, Hypertension.

[110]  Phuong Chung,et al.  Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan , 2003, Nature.

[111]  R. Baruchello,et al.  Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. , 2003, Journal of medicinal chemistry.

[112]  Eun-Young Kim,et al.  Synthesis and evaluation of cytotoxicity of stilbene analogues , 2003, Archives of pharmacal research.

[113]  L. Guarente,et al.  How does calorie restriction work? , 2003, Genes & development.

[114]  U. Förstermann,et al.  Resveratrol, a Polyphenolic Phytoalexin Present in Red Wine, Enhances Expression and Activity of Endothelial Nitric Oxide Synthase , 2002, Circulation.

[115]  R. Weinberg,et al.  hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase , 2001, Cell.

[116]  Yihai Cao,et al.  Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[117]  G. Maga,et al.  Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol* , 2001, The Journal of Biological Chemistry.

[118]  Y. Kimura,et al.  Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (Part 2). , 2000, Anticancer research.

[119]  Jen-kun Lin,et al.  Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate. , 2000, Journal of agricultural and food chemistry.

[120]  P. Kopp.  Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? , 1998, European journal of endocrinology.

[121]  Norman R. Farnsworth,et al.  Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes , 1997, Science.

[122]  J. Folkman.  Tumor angiogenesis: therapeutic implications. , 1971, The New England journal of medicine.

[123]  M. Shen,et al.  The vasorelaxing effect of resveratrol on abdominal aorta from rats and its underlying mechanisms. , 2013, Vascular pharmacology.

[124]  W. Geldenhuys,et al.  Natural products of dietary origin as lead compounds in virtual screening and drug design. , 2012, Current pharmaceutical biotechnology.

[125]  K. Brown,et al.  Resveratrol in human cancer chemoprevention--choosing the 'right' dose. , 2012, Molecular nutrition & food research.

[126]  S. Chan,et al.  Resveratrol derivative, trans‐3,5,4′‐trimethoxystilbene, exerts antiangiogenic and vascular‐disrupting effects in zebrafish through the downregulation of VEGFR2 and cell‐cycle modulation , 2010, Journal of cellular biochemistry.

[127]  J. Fischer,et al.  Supercritical fluid extraction of piceid, resveratrol and emodin from Japanese knotweed , 2010 .

[128]  M. Maraschin,et al.  Trans-resveratrol inhibits early blood vessel formation (vasculogenesis) without impairment of embryonic growth. , 2008, Journal of pharmacological sciences.

[129]  L. Peshkin,et al.  Supplemental Data Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span , 2008 .

[130]  Yun Chen,et al.  Review. Pro- and anti-angiogenesis effects of resveratrol. , 2007, In vivo.

[131]  N. Maulik,et al.  Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1 , 2006, Cell Biochemistry and Biophysics.

[132]  S. Fulda,et al.  Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review. , 2006, Cancer detection and prevention.

[133]  M. J. Atten,et al.  Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. , 2005, Investigational new drugs.

[134]  C. Klinge,et al.  Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. , 2005, The Journal of biological chemistry.

[135]  S. Negrotto,et al.  [Angiogenesis in cancer]. , 2002, Medicina.

[136]  G. Calabrese.  Nonalcoholic compounds of wine: the phytoestrogen resveratrol and moderate red wine consumption during menopause. , 1999, Drugs under experimental and clinical research.

[137]  A. Handley.  Extraction methods in organic analysis , 1999 .