Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Toshiko Tanaka | C. Gieger | F. Kronenberg | A. Uitterlinden | T. Spector | I. Deary | L. Kiemeney | E. Boerwinkle | T. Hansen | O. Pedersen | N. Grarup | A. Astrup | D. Schlessinger | R. Mikolajczyk | Y. Kamatani | Y. Okada | H. Völzke | J. Kaufman | K. Matsuda | A. Köttgen | Qiong Yang | F. Rivadeneira | C. Fox | T. Ahluwalia | J. Hui | J. Beilby | B. Psaty | D. Arking | C. Meisinger | J. Rotter | H. Zheng | J. Starr | M. Beekman | J. Deelen | P. Slagboom | J. Eriksson | J. Richards | M. Kubo | N. Soranzo | J. Jukema | G. Homuth | A. Petersmann | A. Teumer | A. Ekici | M. Ikram | S. Harris | P. Redmond | B. Wolffenbuttel | D. Liewald | J. Lahti | F. Cucca | I. Nolte | R. Rawal | S. Sanna | T. Sørensen | Yolande F M Ramos | A. Hicks | P. Pramstaller | T. Galesloot | T. Visser | E. Rietzschel | M. D. De Buyzere | T. Fiers | M. den Heijer | C. Fuchsberger | A. Linneberg | B. Thuesen | T. Ittermann | A. De Grandi | E. Kajantie | A. Arnold | E. Porcu | D. Stott | D. van Heemst | I. Ford | E. V. Appel | I. Postmus | Matthijs Moed | D. Mascalzoni | K. Eckardt | R. Peeters | R. Netea-Maier | E. Lim | J. Walsh | M. Gögele | C. Pattaro | D. Toniolo | K. Greiser | M. Akiyama | M. Traglia | Scott G Wilson | D. Taliun | L. Chaker | M. Medici | S. Naitza | U. Schultheiss | A. Cappola | Yong Li | T. De Meyer | C. Sala | C. Barbieri | R. Jensen | E. Selvin | H. E. Meyer zu Schwabedissen | B. Lapauw | M. Kloppenburg | I. Meulenbelt | Y. Taes | S. Bekaert | E. Fiorillo | G. Ceresini | Shuo Li | C. Cerqueira | W. D. den Hollander | Suzanne J Brown | D. Tiller | M. Marina | Purdey J Campbell | M. Pala | W. Visser | S. Groeneweg | Celia Di Munno | Luigi Ferrrucci | Kadri Haljas | Jiaojiao Jing | E. Kasbohm | D. Medenwald | G. Roef | S. Brown | T. de Meyer | S. Wilson | Charlotte Cerqueira | Mauro Pala | Houfeng Zheng | A. Uitterlinden | Michela Traglia | M. Kubo | Toshiko Tanaka | P. Slagboom | J. Eriksson | B. Psaty | S. Harris | J. B. Richards | S. Wilson | J. Walsh

[1]  P. Macfarlane,et al.  Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation , 2017, Circulation.

[2]  O. Franco,et al.  Association of Thyroid Function With Life Expectancy With and Without Cardiovascular Disease: The Rotterdam Study , 2017, JAMA internal medicine.

[3]  T. Visser,et al.  Outward‐Open Model of Thyroid Hormone Transporter Monocarboxylate Transporter 8 Provides Novel Structural and Functional Insights , 2017, Endocrinology.

[4]  J. Jonklaas,et al.  Hypothyroidism , 2017, The Lancet.

[5]  Devin P. Sullivan,et al.  A subcellular map of the human proteome , 2017, Science.

[6]  Shuai Jiang,et al.  Effects of multiple genetic loci on the pathogenesis from serum urate to gout , 2017, Scientific Reports.

[7]  A. Köttgen,et al.  GenToS: Use of Orthologous Gene Information to Prioritize Signals from Human GWAS , 2016, PloS one.

[8]  O. Franco,et al.  Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis. , 2016, The Journal of clinical endocrinology and metabolism.

[9]  Stephen Burgess,et al.  PhenoScanner: a database of human genotype–phenotype associations , 2016, Bioinform..

[10]  J. Köhrle,et al.  Few Amino Acid Exchanges Expand the Substrate Spectrum of Monocarboxylate Transporter 10. , 2016, Molecular endocrinology.

[11]  Joseph K. Pickrell,et al.  Detection and interpretation of shared genetic influences on 42 human traits , 2015, Nature Genetics.

[12]  P. Visscher,et al.  Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets , 2016, Nature Genetics.

[13]  Arthur J. L. Cooper,et al.  Reciprocal Control of Thyroid Binding and the Pipecolate Pathway in the Brain , 2016, Neurochemical Research.

[14]  O. Franco,et al.  Normal Thyroid Function and the Risk of Atrial Fibrillation: the Rotterdam Study. , 2015, The Journal of clinical endocrinology and metabolism.

[15]  M. Noda.  Possible role of glial cells in the relationship between thyroid dysfunction and mental disorders , 2015, Front. Cell. Neurosci..

[16]  O. Franco,et al.  Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis. , 2015, The Journal of clinical endocrinology and metabolism.

[17]  T. Visser,et al.  Genetic determination of the hypothalamic-pituitary-thyroid axis: where do we stand? , 2015, Endocrine reviews.

[18]  Jie Huang,et al.  Whole-genome sequence-based analysis of thyroid function , 2015, Nature communications.

[19]  B. Psaty,et al.  Thyroid function in the euthyroid range and adverse outcomes in older adults. , 2015, The Journal of clinical endocrinology and metabolism.

[20]  J. Hirschhorn,et al.  Biological interpretation of genome-wide association studies using predicted gene functions , 2015, Nature Communications.

[21]  Gabi Kastenmüller,et al.  SNiPA: an interactive, genetic variant-centered annotation browser , 2014, Bioinform..

[22]  M. Daly,et al.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.

[23]  A. Bianco,et al.  Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis. , 2014, Endocrinology.

[24]  W. Wiersinga.  Paradigm shifts in thyroid hormone replacement therapies for hypothyroidism , 2014, Nature Reviews Endocrinology.

[25]  A. Hofman,et al.  Thyroid function within the normal range and the risk of depression: a population-based cohort study. , 2014, The Journal of clinical endocrinology and metabolism.

[26]  Chapelle,et al.  University of Birmingham Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease , 2014 .

[27]  M. Daly,et al.  Searching for missing heritability: Designing rare variant association studies , 2014, Proceedings of the National Academy of Sciences.

[28]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[29]  Tom Fiers,et al.  Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men. , 2013, European journal of endocrinology.

[30]  J. Kaufman,et al.  Thyroid hormone levels within reference range are associated with heart rate, cardiac structure, and function in middle-aged men and women. , 2013, Thyroid : official journal of the American Thyroid Association.

[31]  Cisca Wijmenga,et al.  Clinical implications of shared genetics and pathogenesis in autoimmune diseases , 2013, Nature Reviews Endocrinology.

[32]  T. Visser,et al.  Importance of His192 in the human thyroid hormone transporter MCT8 for substrate recognition. , 2013, Endocrinology.

[33]  Lorna M. Lopez,et al.  A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function , 2013, PLoS genetics.

[34]  Manuel A. R. Ferreira,et al.  Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA , 2012, PloS one.

[35]  Steve D. M. Brown,et al.  The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping , 2012, Mammalian Genome.

[36]  Y. Moriyama,et al.  A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. , 2012, American journal of physiology. Cell physiology.

[37]  J. Franklyn,et al.  Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. , 2012, Archives of internal medicine.

[38]  B. Biondi,et al.  Subclinical thyroid disease , 2012, The Lancet.

[39]  Kari Stefansson,et al.  Discovery of common variants associated with low TSH levels and thyroid cancer risk , 2012, Nature Genetics.

[40]  J. Barnhill,et al.  Abnormal thyroid function tests in psychiatric patients: a red herring? , 2012, The American journal of psychiatry.

[41]  Christian Fuchsberger,et al.  GWAtoolbox: an R package for fast quality control and handling of genome-wide association studies meta-analysis data , 2012, Bioinform..

[42]  Nicholas Eriksson,et al.  Novel Associations for Hypothyroidism Include Known Autoimmune Risk Loci , 2011, PloS one.

[43]  Melissa A. Basford,et al.  Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. , 2011, American journal of human genetics.

[44]  Christian Gieger,et al.  Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk , 2011, Nature.

[45]  V. Frenyó,et al.  Endocrine factors in the hypothalamic regulation of food intake in females: a review of the physiological roles and interactions of ghrelin, leptin, thyroid hormones, oestrogen and insulin , 2011, Nutrition Research Reviews.

[46]  L. Vatten,et al.  Association of thyroid function with estimated glomerular filtration rate in a population-based study: the HUNT study. , 2011, European journal of endocrinology.

[47]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[48]  D. Tagle,et al.  Structure, expression, and function of kynurenine aminotransferases in human and rodent brains , 2010, Cellular and Molecular Life Sciences.

[49]  P. Iglesias,et al.  Thyroid dysfunction and kidney disease. , 2009, European journal of endocrinology.

[50]  T. Visser,et al.  Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10. , 2008, Molecular endocrinology.

[51]  M. Falchi,et al.  Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort , 2008, Clinical endocrinology.

[52]  B. Biondi,et al.  The clinical significance of subclinical thyroid dysfunction. , 2008, Endocrine reviews.

[53]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[54]  T. Visser,et al.  Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. , 2006, Molecular endocrinology.

[55]  G. Abecasis,et al.  Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies , 2006, Nature Genetics.

[56]  T. Visser,et al.  Identification of Monocarboxylate Transporter 8 as a Specific Thyroid Hormone Transporter* , 2003, Journal of Biological Chemistry.

[57]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[58]  K. P. O'Brien,et al.  Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population , 2003, Experimental dermatology.

[59]  G. Folkers,et al.  Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. , 2002, Molecular endocrinology.

[60]  T. Visser,et al.  Thyroid Hormone Transport by the Heterodimeric Human System L Amino Acid Transporter. , 2001, Endocrinology.

[61]  T. Abe,et al.  Printed in U.S.A. Copyright © 2001 by The Endocrine Society Identification of Thyroid Hormone Transporters in Humans: Different Molecules Are Involved in a , 2000 .

[62]  H. Yawo,et al.  Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1* , 1999, The Journal of Biological Chemistry.

[63]  T. Visser,et al.  Synthesis and some properties of sulfate esters and sulfamates of iodothyronines. , 1985, Endocrinology.

[64]  J. Wilkinson.  Recent Work on Thyroid Hormones , 1957, Postgraduate medical journal.

[65]  R. Michel,et al.  Sur la nature des combinaisons iodées excrétées par le foie et le rein après administration de L-thyroxine et de L-3:5:3′-triiodothyronine , 1954 .