Hamster exhibits major differences in organ-specific metabolism of the esophageal carcinogen N-nitrosodiethylamine.

[1]  M. Boroujerdi,et al.  Biotransformation of Xenobiotics , 2015 .

[2]  M. Lang,et al.  Tissue and sex-dependent differences in CYP2A activities in hamsters , 1994, Archives of Toxicology.

[3]  S. Fukushima,et al.  Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo. , 2007, Cancer research.

[4]  Ş. Arslan,et al.  Effects of diabetes on rabbit kidney and lung CYP2E1 and CYP2B4 expression and drug metabolism and potentiation of carcinogenic activity of N-nitrosodimethylamine in kidney and lung. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[5]  G. Block,et al.  A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors , 2005, Cancer Causes & Control.

[6]  L. Loeb,et al.  Environmental and chemical carcinogenesis. , 2004, Seminars in cancer biology.

[7]  S. Hecht Tobacco carcinogens, their biomarkers and tobacco-induced cancer , 2004, Nature Reviews Cancer.

[8]  L. F. Ribeiro Pinto,et al.  An optimized reverse transcription-polymerase chain reaction procedure for the amplification of low-copy Cyp2a3 mRNA in rat esophagus. , 2003, Analytical biochemistry.

[9]  S. De Flora,et al.  Effects of N‐acetylcysteine in an esophageal carcinogenesis model in rats treated with diethylnitrosamine and diethyldithiocarbamate , 2002, International journal of cancer.

[10]  T. Kamataki,et al.  Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase. , 2001, Mutation research.

[11]  T. Glisovic,et al.  Rat oesophageal cytochrome P450 (CYP) monooxygenase system: comparison to the liver and relevance in N-nitrosodiethylamine carcinogenesis. , 2001, Carcinogenesis.

[12]  M. E. Meek,et al.  N-NITROSODIMETHYLAMINE: HAZARD CHARACTERIZATION AND EXPOSURE–RESPONSE ANALYSIS , 2001 .

[13]  M. Tohkin,et al.  Molecular cloning, heterologous expression, and characterization of a novel member of CYP2A in the Syrian hamster. , 1999, Biochimica et biophysica acta.

[14]  M. Tohkin,et al.  Cloning and Characterization of Syrian Hamster Testosterone 7α-Hydroxylase, CYP2A9 , 1998 .

[15]  J. Thompson,et al.  The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. , 1997, Nucleic acids research.

[16]  A. Simpson,et al.  Rapid silver staining and recovery of PCR products separated on polyacrylamide gels. , 1994, BioTechniques.

[17]  H. Bartsch,et al.  Metabolism of nitrosamines and aflatoxin B1 by hamster liver CYP2A enzymes. , 1994, Chemico-biological interactions.

[18]  V. Craddock Cancer of the Esophagus: Approaches to the Etiology , 1993 .

[19]  M. Lang,et al.  Cytochrome P4502A-mediated coumarin 7-hydroxylation and testosterone hydroxylation in mouse and rat lung. , 1993, Pharmacology & toxicology.

[20]  H. Yamazaki,et al.  Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes. , 1992, Carcinogenesis.

[21]  R. Peto,et al.  Chronic nitrosamine ingestion in 1040 rodents: the effect of the choice of nitrosamine, the species studied, and the age of starting exposure. , 1991, Cancer research.

[22]  P Grasso,et al.  Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed dose-response study. , 1991, Cancer research.

[23]  C. S. Yang,et al.  Roles of cytochrome P450IIE1 in the dealkylation and denitrosation of N-nitrosodimethylamine and N-nitrosodiethylamine in rat liver microsomes. , 1990, Carcinogenesis.

[24]  R. Kato,et al.  Complete cDNA sequence of a major 3-methylcholanthrene-inducible cytochrome P-450 isozyme (P-450AFB) of Syrian hamsters with high activity toward aflatoxin B1. , 1989, Biochemical and biophysical research communications.

[25]  M. Lang,et al.  Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes. , 1989, Archives of biochemistry and biophysics.

[26]  M. Lang,et al.  Hepatic mitochondrial coumarin 7-hydroxylase: comparison with the microsomal enzyme. , 1988, Archives of biochemistry and biophysics.

[27]  M. Lang,et al.  Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse. , 1988, Biochemical pharmacology.

[28]  W. Generoso,et al.  Mutation, Cancer, and Malformation , 1985 .

[29]  R. Montesano,et al.  Nitrosamine Metabolism and Carcinogenesis , 1984 .

[30]  A. Aitio A simple and sensitive assay of 7-ethoxycoumarin deethylation. , 1978, Analytical biochemistry.

[31]  K. Herrold Epidermoid carcinomas of esophagus and forestomach induced in Syrian hamsters by N-nitroso-N-methylurethan. , 1966, Journal of the National Cancer Institute.

[32]  P. Magee,et al.  CARCINOGENESIS BY NITROSO COMPOUNDS. , 1964, British medical bulletin.

[33]  R. Schoental EXPERIMENTAL INDUCTION OF SQUAMOUS CARCINOMA OF THE LUNG, OESOPHAGUS AND STOMACH. THE MODE OF THEIR INDUCTION. , 1963, Acta - Unio Internationalis Contra Cancrum.

[34]  P. Magee,et al.  Induction of Squamous Carcinoma of the Lung and of the Stomach and Oesophagus by Diazomethane and N-Methyl-N-Nitroso-Urethane, Respectively , 1962, British Journal of Cancer.

[35]  R. Schoental Interaction of the Carcinogenic N-Methyl-Nitrosourethane with Sulphydryl Groups , 1961, Nature.

[36]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.