Phosphorylation Regulates Id 3 Function in Vascular Smooth Muscle Cells

Understanding the mechanisms that regulate cell cycle progression in vascular smooth muscle cells (VSMCs) is key to understanding and modulating vascular lesion formation. Results of the present study provide the first evidence that phosphorylation of the helix-loop-helix factor Id3 in VSMCs occurs in vitro and in vivo and provides a regulatory switch controlling Id3-induced regulation of p21 and VSMC growth.

[1]  G. Nickenig,et al.  Redox‐sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[2]  G. Nickenig,et al.  Identification of a Novel Redox-Sensitive Gene, Id3, Which Mediates Angiotensin II–Induced Cell Growth , 2002, Circulation.

[3]  L. Berthoux,et al.  Vascular Injury Induces Posttranscriptional Regulation of the Id3 Gene: Cloning of a Novel Id3 Isoform Expressed During Vascular Lesion Formation in Rat and Human Atherosclerosis , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[4]  E. Nabel,et al.  Differential effects of the cyclin-dependent kinase inhibitors p27(Kip1), p21(Cip1), and p16(Ink4) on vascular smooth muscle cell proliferation. , 2000, Circulation.

[5]  J. Polak,et al.  Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial , 1999, The Lancet.

[6]  James M. Roberts,et al.  CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.

[7]  J D Norton,et al.  Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation , 1997, Molecular and cellular biology.

[8]  A Joly,et al.  CVT-313, a Specific and Potent Inhibitor of CDK2 That Prevents Neointimal Proliferation* , 1997, The Journal of Biological Chemistry.

[9]  S. T. Park,et al.  Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins , 1997, Molecular and cellular biology.

[10]  M. Aoki,et al.  Prevention of graft coronary arteriosclerosis by antisense cdk2 kinase oligonucleotide , 1997, Nature Medicine.

[11]  E. Nabel,et al.  Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[12]  G. Hannon,et al.  Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage , 1996, Current Biology.

[13]  K. Kinzler,et al.  p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. , 1995, Genes & development.