Iron-deficiency anemia.

Iron-deficiency anemia is the most common form of anemia in the world. This article reviews the global nature of the disease, iron homeostasis in normal and iron-deficient states, clinical findings, treatment, and causes of iron-resistant iron deficiency.

[1]  P. Ponikowski,et al.  Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency† , 2014, European heart journal.

[2]  D. Swinkels,et al.  Nutritional iron turned inside out: intestinal stress from a gut microbial perspective. , 2014, FEMS microbiology reviews.

[3]  Janos Szebeni,et al.  Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management , 2014, Haematologica.

[4]  A. Cohen-Solal,et al.  High prevalence of iron deficiency in patients with acute decompensated heart failure , 2014, European journal of heart failure.

[5]  S. Fishbane,et al.  Anaemia: FIND-CKD: intravenous iron in predialysis CKD , 2014, Nature Reviews Nephrology.

[6]  J. Stein,et al.  Review article: the nutritional and pharmacological consequences of obesity surgery , 2014, Alimentary pharmacology & therapeutics.

[7]  D. Swinkels,et al.  Hematologic parameters predicting a response to oral iron therapy in chronic inflammation , 2014, Haematologica.

[8]  C. Datz,et al.  Obesity as an Emerging Risk Factor for Iron Deficiency , 2014, Nutrients.

[9]  M. Goenka,et al.  Capsule endoscopy: Present status and future expectation. , 2014, World journal of gastroenterology.

[10]  A. Bircher,et al.  Hypersensitivity from intravenous iron products. , 2014, Immunology and allergy clinics of North America.

[11]  J. Powers,et al.  Diagnosis and management of iron deficiency anemia. , 2014, Hematology/oncology clinics of North America.

[12]  Steve M. Taylor,et al.  Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum , 2014, Nature Communications.

[13]  G. Kemmler,et al.  Prevalence and possible causes of anemia in the elderly: a cross-sectional analysis of a large European university hospital cohort , 2014, Clinical interventions in aging.

[14]  I. Macdougall,et al.  FIND-CKD: a randomized trial of intravenous ferric carboxymaltose versus oral iron in patients with chronic kidney disease and iron deficiency anaemia , 2014, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[15]  J. Fernández-Real,et al.  Effects of iron overload on chronic metabolic diseases. , 2014, The lancet. Diabetes & endocrinology.

[16]  L. De‐Regil,et al.  Iron supplementation benefits physical performance in women of reproductive age: a systematic review and meta-analysis. , 2014, The Journal of nutrition.

[17]  S. Rivella,et al.  IDENTIFICATION OF ERYTHROFERRONE AS AN ERYTHROID REGULATOR OF IRON METABOLISM , 2014, Nature Genetics.

[18]  A. Prentice,et al.  Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children. , 2014, Blood.

[19]  A. Gasbarrini,et al.  Clinical effects of Helicobacter pylori outside the stomach , 2014, Nature Reviews Gastroenterology &Hepatology.

[20]  D. Bregman,et al.  Experience with intravenous ferric carboxymaltose in patients with iron deficiency anemia , 2014, Therapeutic advances in hematology.

[21]  Kara J Kallies,et al.  Incidence, treatment, and outcomes of iron deficiency after laparoscopic Roux-en-Y gastric bypass: a 10-year analysis. , 2014, Journal of the American College of Surgeons.

[22]  Seth R Flaxman,et al.  A systematic analysis of global anemia burden from 1990 to 2010. , 2014, Blood.

[23]  C. Camaschella,et al.  How I treat unexplained refractory iron deficiency anemia. , 2014, Blood.

[24]  S. Schrier,et al.  Evaluation and management of anemia in the elderly , 2014, American journal of hematology.

[25]  David C. Ford,et al.  Efficacy and safety of IV ferumoxytol for adults with iron deficiency anemia previously unresponsive to or unable to tolerate oral iron , 2013, American journal of hematology.

[26]  R. Harrington,et al.  A multicenter, randomized, active‐controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia , 2013, Transfusion.

[27]  T. Deloughery Microcytic anemia. , 2014, The New England journal of medicine.

[28]  Avantika Gupta,et al.  A Randomised Controlled Trial to Compare Intravenous Iron Sucrose and Oral Iron in Treatment of Iron Deficiency Anemia in Pregnancy , 2014, Indian Journal of Hematology and Blood Transfusion.

[29]  C. Camaschella Iron and hepcidin: a story of recycling and balance. , 2013, Hematology. American Society of Hematology. Education Program.

[30]  W. Strauss,et al.  Safety and efficacy of total dose infusion of 1,020 mg of ferumoxytol administered over 15 min , 2013, American journal of hematology.

[31]  F. Locatelli,et al.  Variation in intravenous iron use internationally and over time: the Dialysis Outcomes and Practice Patterns Study (DOPPS). , 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[32]  C. Lees,et al.  The management of iron deficiency in inflammatory bowel disease – an online tool developed by the RAND/UCLA appropriateness method , 2013, Alimentary pharmacology & therapeutics.

[33]  C. Peyssonnaux,et al.  The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions. , 2013, Blood.

[34]  J. Byrnes,et al.  Emerging causes of iron deficiency anemia refractory to oral iron supplementation. , 2013, World journal of gastrointestinal pharmacology and therapeutics.

[35]  D. Nickerson,et al.  Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians. , 2013, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[36]  Gretchen A. Stevens,et al.  Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: a systematic analysis of population-representative data , 2013, The Lancet. Global health.

[37]  I. Cavill,et al.  Guideline for the laboratory diagnosis of functional iron deficiency , 2013, British journal of haematology.

[38]  M. Muckenthaler,et al.  Iron refractory iron deficiency anemia , 2013, Haematologica.

[39]  Mustafa Khasraw,et al.  Small bowel video capsule endoscopy: an overview , 2013, Expert review of gastroenterology & hepatology.

[40]  C. Brugnara,et al.  Red cell indices in classification and treatment of anemias: from M.M. Wintrobes's original 1934 classification to the third millennium , 2013, Current opinion in hematology.

[41]  A. Rubio‐Tapia,et al.  ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease , 2013, The American Journal of Gastroenterology.

[42]  J. Heidelbaugh Proton pump inhibitors and risk of vitamin and mineral deficiency: evidence and clinical implications , 2013, Therapeutic advances in drug safety.

[43]  P. Ponikowski,et al.  Iron status in patients with chronic heart failure. , 2013, European heart journal.

[44]  C. Camaschella How I manage patients with atypical microcytic anaemia , 2013, British journal of haematology.

[45]  P. Ponikowski,et al.  The effect of intravenous ferric carboxymaltose on health-related quality of life in patients with chronic heart failure and iron deficiency: a subanalysis of the FAIR-HF study , 2012, European heart journal.

[46]  J. Stockman Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration , 2013 .

[47]  B. Biggs,et al.  Control of iron de fi ciency anemia in low-and middle-income countries , 2013 .

[48]  A. Prentice,et al.  Hepcidin and the Iron-Infection Axis , 2012, Science.

[49]  Qian Wu,et al.  TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia. , 2012, Human molecular genetics.

[50]  J. Strong,et al.  UK guidelines on the management of iron deficiency in pregnancy , 2012, British journal of haematology.

[51]  B. Brabin,et al.  Real-time PCR Demonstrates Ancylostoma duodenale Is a Key Factor in the Etiology of Severe Anemia and Iron Deficiency in Malawian Pre-school Children , 2012, PLoS neglected tropical diseases.

[52]  Michela Traglia,et al.  TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals. , 2011, Blood.

[53]  I. Macdougall Iron supplementation in nephrology and oncology: what do we have in common? , 2011, The oncologist.

[54]  D. Girelli,et al.  Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations , 2011, Journal of Medical Genetics.

[55]  L. Kiemeney,et al.  Serum hepcidin: reference ranges and biochemical correlates in the general population. , 2011, Blood.

[56]  P. Ponikowski,et al.  Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches , 2011, Nature Reviews Cardiology.

[57]  H. Tsukamoto,et al.  Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. , 2011, Blood.

[58]  Gritta E. Janka-Shaub Iron-refractory iron deficiency anemia (irida) , 2011 .

[59]  M. Auerbach,et al.  Clinical use of intravenous iron: administration, efficacy, and safety. , 2010, Hematology. American Society of Hematology. Education Program.

[60]  T. Ganz,et al.  Detection, evaluation, and management of iron-restricted erythropoiesis. , 2010, Blood.

[61]  J. Dahlerup,et al.  The health care cost of intravenous iron treatment in IBD patients depends on the economic evaluation perspective. , 2010, Journal of Crohn's & colitis.

[62]  Matthias W. Hentze,et al.  Two to Tango: Regulation of Mammalian Iron Metabolism , 2010, Cell.

[63]  S. Bandinelli,et al.  Proinflammatory state, hepcidin, and anemia in older persons. , 2010, Blood.

[64]  Toshiko Tanaka,et al.  A genome-wide association analysis of serum iron concentrations. , 2010, Blood.

[65]  P. Ponikowski,et al.  Ferric carboxymaltose in patients with heart failure and iron deficiency. , 2009, The New England journal of medicine.

[66]  Ian H. Frazer,et al.  Common variants in TMPRSS6 are associated with iron status and erythrocyte volume , 2009, Nature Genetics.

[67]  E. McLean,et al.  Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005 , 2009, Public Health Nutrition.

[68]  Jerry Kaplan,et al.  The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. , 2008, Cell metabolism.

[69]  B. Beutler,et al.  The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency , 2008, Science.

[70]  N. Andrews,et al.  Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA) , 2008, Nature Genetics.

[71]  O. Jolobe Reticulocyte haemoglobin content vs. soluble transferrin receptor and ferritin index in iron deficiency anaemia accompanied with inflammation , 2008, International journal of laboratory hematology.

[72]  E. Beutler,et al.  The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? , 2006, Blood.

[73]  Robert E Black,et al.  Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial , 2006, The Lancet.

[74]  S. McGarvey,et al.  Human schistosomiasis and anemia: the relationship and potential mechanisms. , 2005, Trends in parasitology.

[75]  L. Goodnough,et al.  Anemia of chronic disease. , 2005, The New England journal of medicine.

[76]  Matthias W. Hentze,et al.  Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization , 2004 .