A coupling numerical simulation technology which combined computational fluid dynamics (CFD) method with computational structure dynamic (CSD) is developed. Several kinds of mode to exchange data for CFD/CSD coupled computation is designed. In this paper, aeroelastic response of hypersonic wing under Ma 5 wind tunnel experimental condition is calculated and compared with piston theory method as an example. The influence of coupling mode is discussed. The computed result indicates CDF/CSD method of aeroelastic simulation on the threedimensional wing is feasible and credible.