IN SILICO CELL I. HIERARCHICAL APPROACH AND GENERALIZED HILL FUNCTIONS IN MODELING ENZYMATIC REACTIONS AND GENE EXPRESSION REGULATION

SUMMARY Motivation: Development of an in silico cell is an urgent task of systems biology. The core of this cell should consist of mathematical models of intracellular events, including enzymatic reactions and control of gene expression. Results: In this study, we put forward a concept of hierarchical modeling of intracellular processes. A class of generalized Hill functions is determined, and a method for modeling enzymatic reactions and gene expression events with the use of this class is proposed.