Effect of Tibetan Bawei chenxiang powder on acute hypoxic cerebral ischemia-reperfusion injury in the rat

Objective To explore the effect of Tibetan Bawei chenxiang powder on hypoxic cerebral ischemia-reperfusion injury in rats.Methods Wistar rats were randomly divided into 5 groups for the normoxic control,hypoxic and Tibetan Bawei chenxiang powder scattered high,medium and low-dose groups.Rats in hypoxic and Tibetan Bawei chenxiang powder scattered high,medium and low-dose groups were placed into the low-voltage analog cabin altitude of 5 500 meters hypoxia.Rats in normoxic control and the hypoxic groups were fed with 0.9% saline.Rats in Tibetan Bawei chenxiang powder groups were fed with drug in adult dose of 20,15 and 10 times for 14 days.Model of cerebral ischemia-reperfusion injury was made.Hb,Hct,malonaldehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),nitric oxide(NO),endothelin(ET)-1 were measured.Results Different dose of Tibetan Bawei chenxiang powder could significantly reduce the ET-1 levels(P0.05),while compared with hypoxia group,MDA,SOD,GSH,GSH-Px and NO in Tibetan Bawei chenxiang powder groups were also significantly different(P0.05).Conclusions Tibetan Bawei chenxiang powder under hypoxia has protective effect on cerebral ischemia-reperfusion injury.