In vivo growth inhibition of sarcoma 180 by Kielmeyera rugosa Choisy (Calophyllaceae)

The plant Kielmeyera rugosa Choisy (family Calophyllaceae), popularly known as ‘pau-santo’, is traditionally used in Brazilian folk medicine. Recently, the dichloromethane extract–dichloromethane partition from stems of K. rugosa (KR) has shown positive results in our cytotoxic screening programme. Therefore, the aim of this study was to validate the antitumour activity of KR on sarcoma 180 tumour-bearing mice. KR showed antitumour activity with both administration routes: intraperitoneal (50 and 100 mg/kg/day) and oral (100 and 200 mg/kg/day). Tumour growth inhibition rates were 40.8–34.9% and 25.4–51.8% after intraperitoneal and oral administrations, respectively. Treatment with KR did not significantly affect body mass, macroscopy of the organs or blood leukocyte counts. In conclusion, KR exhibited an in vivo antitumour effect without substantial toxicity.

[1]  B. Bing,et al.  Anti-tumour and immunomodulating activities of diosgenin, a naturally occurring steroidal saponin , 2012, Natural product research.

[2]  T. S. Sampaio,et al.  Evaluation of the Cytotoxic Activity of Some Brazilian Medicinal Plants , 2012, Planta Medica.

[3]  C. Biesdorf,et al.  Assessment of anxiolytic and panicolytic effects of dichloromethane fraction from stems of Kielmeyera coriacea. , 2012, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[4]  M. O. Moraes,et al.  In Vitro and In Vivo Antitumor Effects of the Essential Oil from the Leaves of Guatteria friesiana , 2012, Planta medica.

[5]  M. Musa,et al.  Cytotoxic activity of new acetoxycoumarin derivatives in cancer cell lines. , 2011, Anticancer research.

[6]  L. Espindola,et al.  Cytotoxicity of δ-tocotrienols from Kielmeyera coriacea against cancer cell lines. , 2011, Bioorganic & medicinal chemistry.

[7]  C. Shayo,et al.  Coumarins: old compounds with novel promising therapeutic perspectives. , 2010, Current medicinal chemistry.

[8]  D. Cortez,et al.  Effect of xanthone from Kielmeyera coriacea stems on serotonergic neurons of the median raphe nucleus. , 2010, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[9]  L. Espindola,et al.  Evaluation of the antifungal potential of Brazilian Cerrado medicinal plants , 2009, Mycoses.

[10]  L. Espindola,et al.  Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines. , 2009, Journal of ethnopharmacology.

[11]  P. Alves,et al.  Chemical constituents from Kielmeyera rugosa Choisy (Clusiaceae) , 2008 .

[12]  L. Costa-Lotufo,et al.  In vitro and in vivo antitumor effect of 5‐FU combined with piplartine and piperine , 2008, Journal of applied toxicology : JAT.

[13]  T. S. Sampaio,et al.  Volatile compounds of the leaves, flowers and fruits of Kielmeyera rugosa Choisy (Clusiaceae) , 2007 .

[14]  E. Molden,et al.  Evaluation of microsomal incubation conditions on CYP3A4-mediated metabolism of cyclosporine A by a statistical experimental design. , 2006, Current drug metabolism.

[15]  D. Soejarto,et al.  Biodiversity as a source of anticancer drugs. , 2006, Current drug targets.

[16]  Mahabir P. Gupta,et al.  Cytotoxic 4-phenylcoumarins from the leaves of Marila pluricostata. , 2005, Journal of natural products.

[17]  Ji-Min Kim,et al.  Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model. , 2003, Experimental animals.

[18]  A. Ferreira,et al.  Antibacterial xanthones from Kielmeyera variabilis mart. (Clusiaceae). , 2003, Memorias do Instituto Oswaldo Cruz.

[19]  G. Cordell,et al.  New bioactive coumarins from Kielmeyera albopunctata. , 2003, Journal of natural products.

[20]  M. Brandão,et al.  Biological screening of Brazilian medicinal plants. , 2000, Memorias do Instituto Oswaldo Cruz.

[21]  C. Daniel-Ribeiro,et al.  Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malaria. , 2000, Memorias do Instituto Oswaldo Cruz.

[22]  L. de Andrés,et al.  [Toxicity from 5-fluorouracil]. , 1991, Revista clinica espanola.