Appendicectomy and multiple sclerosis risk

Background:  Appendicectomy for acute appendicitis, but not for other causes, is inversely associated with immune‐mediated diseases such as ulcerative colitis, suggesting appendicitis is a marker of immune characteristics influencing immune‐mediated disease risk. This study investigated the association of appendectomy and its underlying diagnosis with multiple sclerosis (MS).

[1]  M. Weller,et al.  CANCER RISK AMONG PATIENTS WITH MULTIPLE SCLEROSIS AND THEIR PARENTS , 2010, Neurology.

[2]  W. Hop,et al.  Cigarette smoking and risk of MS in multiplex families , 2009, Multiple sclerosis.

[3]  J. Pollard,et al.  MS: is it one disease? , 2009, International MS journal.

[4]  J. Hillert,et al.  Maternal smoking during pregnancy and multiple sclerosis amongst offspring , 2008, European journal of neurology.

[5]  M. Salvetti,et al.  B cells and multiple sclerosis , 2008, The Lancet Neurology.

[6]  A. Ekbom,et al.  Maternal Smoking During Pregnancy, Other Prenatal and Perinatal Factors, and the Risk of Legg-Calvé-Perthes Disease , 2008, Pediatrics.

[7]  L. Nyström,et al.  Smoking worsens the prognosis in multiple sclerosis , 2008, Multiple sclerosis.

[8]  J. Gómez-Rial,et al.  Accuracy of CSF and MRI criteria for dissemination in space in the diagnosis of multiple sclerosis , 2008, Journal of the Neurological Sciences.

[9]  J. Ludvigsson,et al.  Diagnosis underlying appendectomy and coeliac disease risk. , 2006, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[10]  G. Ebers.  Prognostic factors for multiple sclerosis: the importance of natural history studies , 2005, Journal of Neurology.

[11]  R. Pounder,et al.  Smoking in adults and passive smoking in children are associated with acute appendicitis , 1999, The Lancet.

[12]  K. Hyllested,et al.  Risk factors in multiple sclerosis: Tuberculin reactivity, age at measles infection, tonsillectomy and appendectomy , 1981, Acta neurologica Scandinavica.

[13]  A. Lunde,et al.  The person-number systems of Sweden, Norway, Denmark, and Israel. , 1980, Vital and health statistics. Series 2, Data evaluation and methods research.

[14]  M. Desrosiers,et al.  Immunological features in multiple sclerosis. , 1976, British medical journal.

[15]  D. Poskanzer,et al.  Tonsillectomy and multiple sclerosis. , 1966, Lancet.

[16]  R. Biggar,et al.  Appendectomy and protection against ulcerative colitis. , 2001, The New England journal of medicine.