Outcome Assessment for Spasticity Management in the Patient With Traumatic Brain Injury: The State of the Art

The objective of this article was to (1) review the engineering and medical literature to structure the available information concerning the assessment of spasticity in the neurological population; (2) to discuss the strengths and weaknesses of the different methods currently in use in spasticity assessment; and (3) make recommendations for future efforts in spasticity outcome assessment. Spasticity textbooks, Web sites, and OVID, IEEE, and Medline searches from 1966 through 2003 of spasticity, quantitative measure, or outcome assessment in the rehabilitation population were used as data sources. Over 500 articles were reviewed. Articles that discussed outcome measures used to assess interventions and evaluation of spasticity were included. Authors reviewed the articles looking at inclusion criteria, data collection, methodology, assessment methods, and conclusions for validity and relevance to this article. Issues such as clinical relevance, real-world function and lack of objectivity, and time consumed during performance are important issues for spasticity assessment. Some measures such as the Ashworth Scale remain in common use secondary to ease of use despite their obvious functional limitations. More functional outcome goals are plagued by being more time consuming and a general inability to demonstrate changes after an intervention. This may be secondary to the other factors that combine with spasticity to cause dysfunction at that level. Quantitative metrics can provide more objective measurements but their clinical relevance is sometimes problematic. The assessment of spasticity outcome is still somewhat problematic. Further work is necessary to develop measures that have real-world functional significance to both the individuals being treated and the clinicians. A lack of objectivity is still a problem. In the future it is important for clinicians and the engineers to work together in the development of better outcome measures.

[1]  J. D. Janssen,et al.  A triaxial accelerometer and portable data processing unit for the assessment of daily physical activity , 1997, IEEE Transactions on Biomedical Engineering.

[2]  Ross Zafonte,et al.  Inter- and intrarater reliability of the Ashworth Scale and the Disability Assessment Scale in patients with upper-limb poststroke spasticity. , 2002, Archives of physical medicine and rehabilitation.

[3]  Gerry E Conti,et al.  Changes in movement characteristics of the spastic upper extremity after botulinum toxin injection. , 2003, Archives of physical medicine and rehabilitation.

[4]  S. Allison,et al.  Reliability of the Modified Ashworth Scale in the assessment of plantarflexor muscle spasticity in patients with traumatic brain injury , 1996, International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation.

[5]  S L Wolf,et al.  Modified Emory Functional Ambulation Profile: An Outcome Measure for the Rehabilitation of Poststroke Gait Dysfunction , 2001, Stroke.

[6]  P. van Vliet,et al.  Reliability of measurements obtained with the modified Ashworth scale in the lower extremities of people with stroke. , 2002, Physical therapy.

[7]  M. Brown,et al.  Physical and performance measures for the identification of mild to moderate frailty. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[8]  W. Rymer,et al.  Long-lasting reductions of spasticity induced by skin electrical stimulation. , 1996, IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.

[9]  W. Rymer,et al.  Understanding and treating arm movement impairment after chronic brain injury: progress with the ARM guide. , 2014, Journal of rehabilitation research and development.

[10]  Michael P Barnes,et al.  Are we underestimating the clinical efficacy of botulinum toxin (type A)? Quantifying changes in spasticity, strength and upper limb function after injections of Botox® to the elbow flexors in a unilateral stroke population , 2002, Clinical rehabilitation.

[11]  C. Sköld,et al.  Spasticity in spinal cord injury: self- and clinically rated intrinsic fluctuations and intervention-induced changes. , 2000, Archives of physical medicine and rehabilitation.

[12]  I. Milanov,et al.  Mechanisms of tizanidine action on spasticity , 1994, Acta neurologica Scandinavica.

[13]  B. Bussel,et al.  Effects of intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects , 1999, Experimental Brain Research.

[14]  JoAnne K. Gronley,et al.  Classification of walking handicap in the stroke population. , 1995, Stroke.

[15]  G S Rash,et al.  A demonstration of validity of 3-D video motion analysis method for measuring finger flexion and extension. , 1999, Journal of biomechanics.

[16]  C. Wiktorin,et al.  A triaxial accelerometer for measuring arm movements. , 2002, Applied ergonomics.

[17]  Masaaki Makikawa,et al.  Ambulatory Monitoring of Behavior in Daily Life by Accelerometers Set at Both-Near-Sides of the Joint , 2001, MedInfo.

[18]  P. Filipetti,et al.  [Interest of anesthetic blocks for assessment of the spastic patient. A series of 815 motor blocks]. , 2003, Neuro-Chirurgie.

[19]  J. Ghika,et al.  Portable system for quantifying motor abnormalities in Parkinson's disease , 1993, IEEE Transactions on Biomedical Engineering.

[20]  I. Milanov,et al.  Mechanisms of baclofen action on spasticity , 1992, Acta neurologica Scandinavica.

[21]  Zhiqiang Bai,et al.  A portable intelligent stretching device for treating spasticity and contracture with outcome evaluation , 2002, Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.

[22]  J. H. van der Lee,et al.  The intra- and interrater reliability of the action research arm test: a practical test of upper extremity function in patients with stroke. , 2001, Archives of physical medicine and rehabilitation.

[23]  Richard Greenwood,et al.  Evaluating the role of botulinum toxin in the management of focal hypertonia in adults , 2000, Journal of neurology, neurosurgery, and psychiatry.

[24]  Effects of Surgical Lengthening of the Hamstrings Without a Concomitant Distal Rectus Femoris Transfer in Ambulant Patients With Cerebral Palsy , 2003, Journal of pediatric orthopedics.

[25]  A. Eisen,et al.  Electromyography in Disorders of Muscle Tone , 1987, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[26]  W. Rymer,et al.  Stretch reflex dynamics in spastic elbow flexor muscles , 1989, Annals of neurology.

[27]  F. Mahoney,et al.  FUNCTIONAL EVALUATION: THE BARTHEL INDEX. , 2018, Maryland state medical journal.

[28]  I Jonkers,et al.  Single event multilevel botulinum toxin type A treatment and surgery: similarities and differences , 2001, European journal of neurology.

[29]  N. Alexander,et al.  A clinical measure of maximal and rapid stepping in older women. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[30]  J. McGuire,et al.  Beyond Ashworth. Electrophysiologic quantification of spasticity. , 1998, Physical medicine and rehabilitation clinics of North America.

[31]  P. Pasqualetti,et al.  Botulinum toxin type-A treatment in spastic paraparesis: a neurophysiological study , 2000, Journal of the Neurological Sciences.

[32]  H Rodgers,et al.  Biomechanical examination of a commonly used measure of spasticity. , 2001, Clinical biomechanics.

[33]  N. Westgren,et al.  Quality of life and traumatic spinal cord injury. , 1998, Archives of physical medicine and rehabilitation.

[34]  J. He Stretch reflex sensitivity: effects of postural and muscle length changes. , 1998, IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.

[35]  G. Koshland,et al.  Hyper-reflexia without spasticity after unilateral infarct of the medullary pyramid , 2000, Journal of the Neurological Sciences.

[36]  A. Fugl-Meyer,et al.  The post-stroke hemiplegic patient. 1. a method for evaluation of physical performance. , 1975, Scandinavian journal of rehabilitation medicine.

[37]  G. Whiteneck,et al.  Quantifying handicap: a new measure of long-term rehabilitation outcomes. , 1992, Archives of physical medicine and rehabilitation.

[38]  D. Krebs,et al.  Posturography changes do not predict functional performance changes. , 1998, The American journal of otology.

[39]  D. Nelson,et al.  The use of a game to promote arm reach in persons with traumatic brain injury. , 1993, The American journal of occupational therapy : official publication of the American Occupational Therapy Association.

[40]  B. Conrad,et al.  Increased F-wave duration in patients with spasticity. , 1992, Electromyography and clinical neurophysiology.

[41]  I. Jonkers,et al.  A randomized study of combined botulinum toxin type A and casting in the ambulant child with cerebral palsy using objective outcome measures , 2001, European journal of neurology.

[42]  Fabrizio Pisano,et al.  Quantitative measures of spasticity in post-stroke patients , 2000, Clinical Neurophysiology.

[43]  J. Nilsson,et al.  Functional and clinical changes in upper limb spastic patients treated with botulinum toxin (BTX). , 2000, Functional neurology.

[44]  W Z Rymer,et al.  Hyperactive tendon reflexes in spastic multiple sclerosis: measures and mechanisms of action. , 2000, Archives of physical medicine and rehabilitation.

[45]  G. Eklund,et al.  The effects of muscle vibration in spasticity, rigidity, and cerebellar disorders. , 1968, Journal of neurology, neurosurgery, and psychiatry.

[46]  J. Richards,et al.  A method of dynamic foot-pressure measurement for the evaluation of pediatric orthopaedic foot deformities. , 1998, Journal of pediatric orthopedics.

[47]  John E. Ware,et al.  SF-36 Health Survey Update , 2000, Spine.

[48]  M. L. van der Linden,et al.  Motion analysis of stereotyped hand movements in Rett syndrome. , 2003, Journal of intellectual disability research : JIDR.

[49]  E. Fowler,et al.  Sensitivity of the pendulum test for assessing spasticity in persons with cerebral palsy , 2000, Developmental medicine and child neurology.

[50]  S C Gandevia,et al.  Short-term effects of dynamic lycra splints on upper limb in hemiplegic patients. , 2000, Archives of physical medicine and rehabilitation.

[51]  W. Z. Rymer,et al.  A quantitative and convenient method of evaluating tendon reflex and spasticity , 1999, Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. N.

[52]  D. P. Romilly,et al.  Computer controlled measurement of spasticity , 1993, Proceedings of Canadian Conference on Electrical and Computer Engineering.

[53]  C. D. De Luca,et al.  Topical anesthesia: a possible treatment method for spasticity. , 1981, Archives of physical medicine and rehabilitation.

[54]  L. Bour,et al.  Cumulative vibratory indices and the H/M ratio of the soleus H-reflex: a quantitative study in control and spastic subjects. , 1989, Electroencephalography and clinical neurophysiology.

[55]  J. Froger,et al.  Efficacy of botulinum toxin A in upper limb function of hemiplegic patients , 2002, Journal of Neurology.

[56]  M. Fisher F/M ratios in polyneuropathy and spastic hyperreflexia , 1988, Muscle & nerve.

[57]  R WARTENBERG,et al.  Pendulousness of the Legs as a Diagnostic Test , 1951, Neurology.

[58]  Neuromuscular model for the stretch reflex in passive movement of spastic elbow joint , 1998, Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286).

[59]  S H Pierson,et al.  Outcome measures in spasticity management , 1997, Muscle & nerve. Supplement.

[60]  J. Iles,et al.  Presynaptic inhibition of monosynaptic reflexes in the lower limbs of subjects with upper motoneuron disease. , 1986, Journal of neurology, neurosurgery, and psychiatry.

[61]  Eljas F. Ragi Amplitude of the F wave , 1981, Neurology.

[62]  J. H. van der Lee,et al.  The responsiveness of the Action Research Arm test and the Fugl-Meyer Assessment scale in chronic stroke patients. , 2001, Journal of rehabilitation medicine.

[63]  J. Obeso,et al.  Reciprocal inhibition between forearm muscles in spastic hemiplegia , 1991, Neurology.

[64]  R. Calderón-González,et al.  [Treatment of spasticity in cerebral palsy with botulinum toxin]. , 2002, Revista de neurologia.

[65]  A F Mak,et al.  Three-dimensional motion analysis of the voluntary elbow movement in subjects with spasticity. , 1997, IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.

[66]  A C Nicol,et al.  Elbow and wrist joint contact forces during occupational pick and place activities. , 2000, Journal of biomechanics.

[67]  Xuguang Wang,et al.  Three-dimensional kinematic analysis of influence of hand orientation and joint limits on the control of arm postures and movements , 1999, Biological Cybernetics.

[68]  R. Adone,et al.  Pharmacological interventions for spasticity following spinal cord injury. , 2000, The Cochrane database of systematic reviews.

[69]  F. Miller,et al.  Long-Term Follow-up of Surgery for Equinovarus Foot Deformity in Children With Cerebral Palsy , 2002, Journal of pediatric orthopedics.

[70]  P. Catlin,et al.  Establishing the reliability and validity of measurements of walking time using the Emory Functional Ambulation Profile. , 1999, Physical therapy.

[71]  O'Neill De,et al.  Posturography changes do not predict functional performance changes. , 1998 .

[72]  E. McAuley,et al.  Gait adjustments in older adults: activity and efficacy influences. , 1998, Psychology and aging.

[73]  A. Harf,et al.  Physiological effects of selective tibial neurotomy on lower limb spasticity , 1997, Journal of neurology, neurosurgery, and psychiatry.

[74]  R. V. van Deursen,et al.  An instrument for the bedside quantification of spasticity: a pilot study , 2001, 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[75]  K. Chua,et al.  Alcohol neurolysis of the sciatic nerve in the treatment of hemiplegic knee flexor spasticity: clinical outcomes. , 2000, Archives of physical medicine and rehabilitation.

[76]  Aris Xanthos,et al.  Introduction , 1965, Studies in Second Language Acquisition.

[77]  John Chae,et al.  Upper Limb Motor Function in Hemiparesis: Concurrent Validity of the Arm Motor Ability Test , 2003, American journal of physical medicine & rehabilitation.

[78]  L. Livingston,et al.  The influence of external orthotic support on the adaptive gait characteristics of individuals with chronically unstable ankles. , 2003, Gait & posture.

[79]  E. Halar,et al.  H-reflex changes following spinal cord injury. , 1985, Archives of physical medicine and rehabilitation.

[80]  C. Granger,et al.  Outcomes in the first 5 years after traumatic brain injury. , 1998, Archives of physical medicine and rehabilitation.

[81]  Vicky McCarthy,et al.  Epidural anesthesia as a technique to control spasticity after surgery in a patient with spinal cord injury. , 2003, Plastic and reconstructive surgery.

[82]  N. STEPHENC.ALLISO,et al.  Sensitivity of qualitative and quantitative spasticity measures to clinical treatment with cryotherapy , 2002 .

[83]  J. Perry The use of gait analysis for surgical recommendations in traumatic brain injury. , 1999, The Journal of head trauma rehabilitation.

[84]  V. Slavov,et al.  Soleus Neurotomy for Treatment of the Spastic Equinus Foot , 2000, Neurosurgery.

[85]  R. Angel,et al.  THE H REFLEX IN NORMAL, SPASTIC, AND RIGID SUBJECTS. , 1963, Archives of neurology.

[86]  D. Goodkin,et al.  Upper extremity function in multiple sclerosis: improving assessment sensitivity with box-and-block and nine-hole peg tests. , 1988, Archives of physical medicine and rehabilitation.

[87]  W Z Rymer,et al.  Joint dependent passive stiffness in paretic and contralateral limbs of spastic patients with hemiparetic stroke. , 1995, Journal of neurology, neurosurgery, and psychiatry.

[88]  G.F. Harris,et al.  Upper extremity motion assessment in adult ischemic stroke patients: a 3-D kinematic model , 2001, 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[89]  James W. Lance,et al.  The control of muscle tone, reflexes, and movement , 1980, Neurology.

[90]  W. Sparrow,et al.  The Relationship Between Lower Body Strength and Obstructed Gait in Community‐Dwelling Older Adults , 2002, Journal of the American Geriatrics Society.

[91]  Katharina Stibrant Sunnerhagen,et al.  A home-based, self-administered stimulation program to improve selected hand functions of chronic stroke. , 2003, NeuroRehabilitation.

[92]  Gregor Schöner,et al.  Goal-equivalent joint coordination in pointing: affect of vision and arm dominance. , 2002, Motor control.

[93]  Little Jw,et al.  H-reflex changes following spinal cord injury. , 1985 .

[94]  I. Hwang,et al.  Quantitative analysis of the velocity related pathophysiology of spasticity and rigidity in the elbow flexors , 2002, Journal of neurology, neurosurgery, and psychiatry.

[95]  J. Perry,et al.  Toe walking: muscular demands at the ankle and knee. , 2003, Archives of physical medicine and rehabilitation.

[96]  Ana M. Gonzalez The Practical Management of Spasticity in Children and Adults , 1991 .

[97]  Rajiv Dubey,et al.  Telerobotic Haptic System to Enhance the Performance of Vocational Tests by Motion-Impaired Users , 2003 .

[98]  B. Ashworth PRELIMINARY TRIAL OF CARISOPRODOL IN MULTIPLE SCLEROSIS. , 1964, The Practitioner.

[99]  A. Rossier,et al.  Has botulinum toxin type A a place in the treatment of spasticity in spinal cord injury patients? , 1998, Spinal Cord.

[100]  KR Westerterp,et al.  Physical activity assessment with accelerometers , 1999, International Journal of Obesity.

[101]  James R. Gage,et al.  Con: Interobserver Variability of Gait Analysis , 2003 .

[102]  M Rappaport,et al.  Disability rating scale for severe head trauma: coma to community. , 1982, Archives of physical medicine and rehabilitation.

[103]  J. Gage,et al.  Gait patterns in spastic hemiplegia in children and young adults. , 1987, The Journal of bone and joint surgery. American volume.

[104]  Li-Shan Chou,et al.  An assessment of gait and balance deficits after traumatic brain injury. , 2003, Archives of physical medicine and rehabilitation.

[105]  A C Nicol,et al.  Measurement of external three-dimensional interphalangeal loads applied during activities of daily living. , 1999, Clinical biomechanics.

[106]  R. Young,et al.  Treatment of spasticity with botulinum toxin , 1992, Annals of neurology.

[107]  Mark Nash,et al.  Effects of functional electrical stimulation training for six months on body composition and spasticity in motor complete tetraplegic spinal cord-injured individuals. , 2002, Journal of rehabilitation medicine.

[108]  I. Milanov A comparative study of methods for estimation of presynaptic inhibition , 1992, Journal of Neurology.

[109]  Wouter Olthuis,et al.  The artificial vestibular system - design of a tri-axial inertial sensor system and its application in the study of human movement , 2001 .

[110]  Diane P. Martin,et al.  A validation of the functional independence measurement and its performance among rehabilitation inpatients. , 1993, Archives of physical medicine and rehabilitation.

[111]  J. Lance The reflex effects of muscle vibration. , 1973, Proceedings of the Australian Association of Neurologists.

[112]  D. Condie,et al.  The effects of botulinum toxin (BTX-A) on spasticity of the lower limb and on gait in cerebral palsy. , 2003, The Journal of bone and joint surgery. British volume.

[113]  W. B. Matthews Ratio of maximum H reflex to maximum M response as a measure of spasticity. , 1966, Journal of neurology, neurosurgery, and psychiatry.

[114]  A. Fugl-Meyer,et al.  Post-stroke hemiplegia assessment of physical properties. , 1980, Scandinavian journal of rehabilitation medicine. Supplement.

[115]  R. Lyle A performance test for assessment of upper limb function in physical rehabilitation treatment and research , 1981, International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation.

[116]  N. L. Svensson,et al.  The influence of surface slope on human gait characteristics: a study of urban pedestrians walking on an inclined surface. , 1996, Ergonomics.

[117]  R. Chan,et al.  Effects of surface spinal cord stimulation on spasticity and quantitative assessment of muscle tone in hemiplegic patients. , 1998, American journal of physical medicine & rehabilitation.

[118]  V. Slavov,et al.  Long term course of the H reflex after selective tibial neurotomy , 2003, Journal of neurology, neurosurgery, and psychiatry.

[119]  A. Sherwood,et al.  Gabapentin for the treatment of spasticity in patients with spinal cord injury , 1997, Spinal Cord.

[120]  Yasin Dhaher,et al.  Reflex Torque Response to Movement of the Spastic Elbow: Theoretical Analyses and Implications for Quantification of Spasticity , 1999, Annals of Biomedical Engineering.

[121]  The leg drop pendulum test under anesthesia part II: normal vs. limbs with spasticity , 2002, Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.

[122]  A. Sunderland,et al.  Arm function after stroke: measurement and recovery over the first three months. , 1987, Journal of neurology, neurosurgery, and psychiatry.

[123]  I. Baguley,et al.  Changes in postural sway and performance of functional tasks during rehabilitation after traumatic brain injury. , 1997, Archives of physical medicine and rehabilitation.

[124]  Chun-Yu Yeh,et al.  Development of a device for prolonged muscle stretch treatment and for quantitative assessment of spasticity , 2000, Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Cat. No.00CH37143).

[125]  V. Mathiowetz,et al.  Adult norms for the Box and Block Test of manual dexterity. , 1985, The American journal of occupational therapy : official publication of the American Occupational Therapy Association.

[126]  B. Bhakta,et al.  Randomised double blind placebo controlled trial of the effect of botulinum toxin on walking in cerebral palsy , 2000, Archives of disease in childhood.

[127]  R. Larsen,et al.  The Satisfaction with Life Scale , 1985, Journal of personality assessment.

[128]  L. Vogel,et al.  Adults With Pediatric-Onset Spinal Cord Injuries: Part 3: Impact Of Medical Complications , 2002, The journal of spinal cord medicine.

[129]  Richard W. Bohannon,et al.  Interrater reliability of a modified Ashworth scale of muscle spasticity. , 1987, Physical therapy.

[130]  G. Petroski,et al.  Inhibitory casting decreases a vibratory inhibition index of the H-reflex in the spastic upper limb. , 1999, Archives of physical medicine and rehabilitation.

[131]  D A Boone,et al.  Step activity monitor: long-term, continuous recording of ambulatory function. , 1999, Journal of rehabilitation research and development.

[132]  T. Ashman,et al.  The reliability and validity of the SF-36 health survey questionnaire for use with individuals with traumatic brain injury. , 2001, Brain injury.

[133]  K M Means,et al.  Use of an obstacle course to assess balance and mobility in the elderly. A validation study. , 1996, American journal of physical medicine & rehabilitation.