Comparison of myointimal hyperplasia in laser-assisted and suture anastomosed arteries. A preliminary report.

Use of the milliwatt CO2 laser to perform microvascular anastomoses is associated with characteristic histologic changes, including intimal hyperplasia and medial necrosis. The extent of myointimal proliferation after both suture and laser-assisted vascular anastomosis was assessed in the rat femoral artery model. At 2 weeks the average intimal height of the laser-anastomosed vessels was 11.7 +/- 2.2 microns (mean +/- standard error of the mean) vs. 21.3 +/- 3.2 microns for sutured arteries (p less than 0.05). By 6 weeks the groups were equivalent (laser, 25.6 +/- 4.6 microns; suture, 17.3 +/- 1.2 microns; p, not significant). The medial changes associated with the laser-assisted method appear to inhibit the proliferative response at 2 weeks but are reversed by 6 weeks.

[1]  J. Breslow,et al.  Absence of enhanced intimal thickening in the response of the carotid arterial wall to endothelial injury in hypercholesterolemic rats. , 1976, Laboratory investigation; a journal of technical methods and pathology.

[2]  R. Mladick.  An accidental tarsorrhaphy caused by acrylic adhesive , 1977 .

[3]  M. Sanmarco,et al.  Accelerated progression of atherosclerosis in coronary vessels with minimal lesions that are bypassed. , 1984, The New England journal of medicine.

[4]  L. Trachtenberg,et al.  THE HISTOPATHOLOGY OF SMALL ARTERIES FOLLOWING EXPERIMENTAL MICROVASCULAR ANASTOMOSIS , 1977, Plastic and reconstructive surgery.

[5]  J. Palmaz,et al.  Postoperative carotid restenosis due to neointimal fibromuscular hyperplasia. Clinical, angiographic, and pathological findings. , 1983, Radiology.

[6]  J. Alksne,et al.  Intimal proliferation of cerebral arteries after subarachnoid blood injection in pigs. , 1984, Journal of neurosurgery.

[7]  M. Reidy,et al.  Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. , 1983, Laboratory investigation; a journal of technical methods and pathology.

[8]  J. Bailes,et al.  Microvascular anastomosis using the milliwatt CO2 laser , 1985 .

[9]  A. Callow,et al.  Early restenosis after carotid endarterectomy. , 1978, Archives of surgery.

[10]  J. Bailes,et al.  Fibrinolytic activity following laser‐assisted vascular anastomosis , 1985, Microsurgery.

[11]  J. Bailes,et al.  Aneurysm formation after low power carbon dioxide laser-assisted vascular anastomosis. , 1986, Neurosurgery.

[12]  R. Ross,et al.  The pathogenesis of atherosclerosis (second of two parts). , 1976, The New England journal of medicine.

[13]  S. K. Powers,et al.  Carotid artery end-to-end anastomosis in the rat using the argon laser. , 1985, Journal of neurosurgery.