Discovery of a novel dual functional phenylpyrazole-styryl hybrid that induces apoptotic and autophagic cell death in bladder cancer cells.
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F. Abas | K. Yusoff | S. Chia | K. Okuda | S. Leong | Qi Su | Jingjing Wang | Yanmin Zhang | Kazuhide S. Okuda
[1] P. A. Valiente,et al. gmx_MMPBSA: A New Tool to Perform End-State Free Energy Calculations with GROMACS. , 2021, Journal of chemical theory and computation.
[2] J. Freeman,et al. Use of Zebrafish in Drug Discovery Toxicology. , 2020, Chemical research in toxicology.
[3] J. Castracane,et al. A Dynamic Culture Method to Produce Ovarian Cancer Spheroids under Physiologically-Relevant Shear Stress , 2018, Cells.
[4] F. Abas,et al. Asymmetrical meta-methoxylated diarylpentanoids: Rational design, synthesis and anti-cancer evaluation in-vitro. , 2018, European journal of medicinal chemistry.
[5] A. Nudelman,et al. Synthesis and Biological Evaluation of Derivatives of Indoline as Highly Potent Antioxidant and Anti-inflammatory Agents. , 2018, Journal of medicinal chemistry.
[6] David Lagorce,et al. FAF‐Drugs4: free ADME‐tox filtering computations for chemical biology and early stages drug discovery , 2017, Bioinform..
[7] Min Wang,et al. Design, synthesis and antitumor activity of Novel Sorafenib derivatives bearing pyrazole scaffold. , 2017, Bioorganic & medicinal chemistry.
[8] X. Bian,et al. Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells , 2017, Autophagy.
[9] Ying Zhang,et al. Design, synthesis and biological evaluation of novel EGFR/HER2 dual inhibitors bearing a oxazolo[4,5-g]quinazolin-2(1H)-one scaffold. , 2016, European journal of medicinal chemistry.
[10] M. Chatzinikolaidou. Cell spheroids: the new frontiers in in vitro models for cancer drug validation. , 2016, Drug discovery today.
[11] M. Lawler,et al. Overcoming Resistance to Targeted Therapies in Cancer. , 2015, Seminars in oncology.
[12] T. Yamanaka,et al. Nedaplatin plus docetaxel versus cisplatin plus docetaxel for advanced or relapsed squamous cell carcinoma of the lung (WJOG5208L): a randomised, open-label, phase 3 trial. , 2015, The Lancet. Oncology.
[13] David Gilligan,et al. Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer. , 2015, The Lancet. Oncology.
[14] Berk Hess,et al. GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers , 2015 .
[15] J. Irwin,et al. An Aggregation Advisor for Ligand Discovery. , 2015, Journal of medicinal chemistry.
[16] H. Christofk,et al. Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy , 2015, Journal of Cell Science.
[17] P. Jänne,et al. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. , 2015, The New England journal of medicine.
[18] F. Abas,et al. Synthesis and Sar Study of Diarylpentanoid Analogues as New Anti-Inflammatory Agents , 2014, Molecules.
[19] Simon C Watkins,et al. A Complex between Atg7 and Caspase-9 , 2013, The Journal of Biological Chemistry.
[20] A. Abadi,et al. Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents. , 2013, European journal of medicinal chemistry.
[21] Steven P Jones,et al. PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. , 2013, The Biochemical journal.
[22] D. Tindall,et al. Autophagy control by the VEGF-C/NRP-2 axis in cancer and its implication for treatment resistance. , 2013, Cancer research.
[23] D. Nguyen,et al. TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation , 2013, Molecular and Cellular Biochemistry.
[24] D. Gozuacik,et al. Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death , 2012, Apoptosis.
[25] O. Prakash,et al. Design, synthesis, computational and biological evaluation of some new hydrazino derivatives of DHA and pyranopyrazoles. , 2012, European journal of medicinal chemistry.
[26] S. Ashton,et al. Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases. , 2012, Bioorganic & medicinal chemistry letters.
[27] Yanmin Zhang,et al. Antitumor Activity of Taspine by Modulating the EGFR Signaling Pathway of Erk1/2 and Akt In Vitro and In Vivo , 2011, Planta medica.
[28] Luhua Lai,et al. Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase. , 2011, Journal of medicinal chemistry.
[29] Yuquan Wei,et al. Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases. , 2011, Journal of medicinal chemistry.
[30] M. Hixon,et al. Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism. , 2011, Biochemistry.
[31] Jai-Sing Yang,et al. Synthesis of 1-benzyl-3-(5-hydroxymethyl-2-furyl)selenolo[3,2-c]pyrazole derivatives as new anticancer agents. , 2010, European journal of medicinal chemistry.
[32] B. Levine,et al. The autophagy effector Beclin 1: a novel BH3-only protein , 2008, Oncogene.
[33] J. Engelman,et al. A sweet new role for EGFR in cancer. , 2008, Cancer cell.
[34] A. Markoe,et al. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. , 2007, The New England journal of medicine.
[35] Robert J. Gillies,et al. Docetaxel induces cell death through mitotic catastrophe in human breast cancer cells , 2005, Molecular Cancer Therapeutics.
[36] G. Kirsch,et al. New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells. , 2005, European journal of medicinal chemistry.
[37] H. Varmus,et al. Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain , 2005, PLoS medicine.
[38] A. Ullrich,et al. The discovery of receptor tyrosine kinases: targets for cancer therapy , 2004, Nature Reviews Cancer.
[39] Min Chen,et al. Initiator caspases in apoptosis signaling pathways , 2002, Apoptosis.
[40] M. Campiglio,et al. Biologic and therapeutic role of HER2 in cancer , 2003, Oncogene.
[41] T. Natsume,et al. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate , 2003, Journal of Cell Science.
[42] M. Komatsu,et al. Human Apg3p/Aut1p Homologue Is an Authentic E2 Enzyme for Multiple Substrates, GATE-16, GABARAP, and MAP-LC3, and Facilitates the Conjugation of hApg12p to hApg5p* , 2002, The Journal of Biological Chemistry.
[43] T. Ueno,et al. The Human Homolog of Saccharomyces cerevisiae Apg7p Is a Protein-activating Enzyme for Multiple Substrates Including Human Apg12p, GATE-16, GABARAP, and MAP-LC3* , 2001, The Journal of Biological Chemistry.
[44] J C Reed,et al. Mechanisms of apoptosis. , 2000, The American journal of pathology.
[45] Michael D. George,et al. A protein conjugation system essential for autophagy , 1998, Nature.
[46] J. Davie,et al. In situ cross-linking by cisplatin of nuclear matrix-bound transcription factors to nuclear DNA of human breast cancer cells. , 1998, Cancer research.
[47] G M Cohen,et al. Caspases: the executioners of apoptosis. , 1997, The Biochemical journal.
[48] H. Gurney,et al. Dose calculation of anticancer drugs: a review of the current practice and introduction of an alternative. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[49] M. Jordan,et al. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[50] Philip R. Cohen,et al. The taxoids: paclitaxel (Taxol) and docetaxel (Taxotere). , 1993, Cancer treatment reviews.
[51] A. Einstein,et al. Treatment of invasive bladder cancer by cisplatin and radiation in patients unsuited for surgery. , 1987, JAMA.