Interferometric and nonlinear-optical spectral-imaging techniques for outer space and live cells

Multidimensional signals such as the spectral images allow us to have deeper insights into the natures of objects. In this paper the spectral imaging techniques that are based on optical interferometry and nonlinear optics are presented. The interferometric imaging technique is based on the unified theory of Van Cittert-Zernike and Wiener-Khintchine theorems and allows us to retrieve a spectral image of an object in the far zone from the 3D spatial coherence function. The retrieval principle is explained using a very simple object. The promising applications to space interferometers for astronomy that are currently in progress will also be briefly touched on. An interesting extension of interferometric spectral imaging is a 3D and spectral imaging technique that records 4D information of objects where the 3D and spectral information is retrieved from the cross-spectral density function of optical field. The 3D imaging is realized via the numerical inverse propagation of the cross-spectral density. A few techniques suggested recently are introduced. The nonlinear optical technique that utilizes stimulated Raman scattering (SRS) for spectral imaging of biomedical targets is presented lastly. The strong signals of SRS permit us to get vibrational information of molecules in the live cell or tissue in real time. The vibrational information of unstained or unlabeled molecules is crucial especially for medical applications. The 3D information due to the optical nonlinearity is also the attractive feature of SRS spectral microscopy.

[1]  K. Itoh,et al.  Analysis and experimental assessment of the sensitivity of stimulated Raman scattering microscopy. , 2009, Optics express.

[2]  K. Itoh,et al.  Label‐free visualization of acetaminophen‐induced liver injury by high‐speed stimulated Raman scattering spectral microscopy and multivariate image analysis , 2014, Pathology international.

[3]  Kazuyoshi Itoh,et al.  Stimulated Raman hyperspectral imaging based on spectral filtering of broadband fiber laser pulses. , 2012, Optics letters.

[4]  Kazuyoshi Itoh,et al.  Fourier-transform spectral imaging: retrieval of source information from three-dimensional spatial coherence , 1986 .

[5]  Khan M. Iftekharuddin,et al.  Optics and Photonics for Information Processing VIII , 2008 .

[6]  Pietro Di Lena,et al.  Interferometric connection of large ground-based telescopes , 1996 .

[7]  H. Matsuo,et al.  Development of a multi-Fourier-transform interferometer: fundamentals. , 2005, Applied optics.

[9]  A. Michelson,et al.  Measurement of the Diameter of Alpha-Orionis by the Interferometer. , 1921, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Mortazavi,et al.  Supporting Online Material Materials and Methods Figs. S1 to S13 Tables S1 to S3 References Label-free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy , 2022 .

[11]  Emil Wolf,et al.  Principles of Optics: Contents , 1999 .

[12]  Kazuyoshi Itoh,et al.  Retrieval of the cross-spectral density propagating in free space , 1999 .

[13]  S. T. Ridgway,et al.  Double Fourier spatio-spectral interferometry - Combining high spectral and high spatial resolution in the near infrared , 1988 .

[14]  Dominic J. Benford,et al.  Tracking near-infrared fringes on BETTII: a balloon-borne, 8m-baseline interferometer , 2012, Other Conferences.

[15]  David T. Leisawitz,et al.  Developing wide-field spatio-spectral interferometry for far-infrared space applications , 2012, Other Conferences.

[16]  G. Pedrini,et al.  Spectrally resolved incoherent holography: 3D spatial and spectral imaging using a Mach-Zehnder radial-shearing interferometer. , 2014, Optics letters.

[17]  Makoto Hattori,et al.  Development of a multi-Fourier-transform interferometer: imaging experiments in millimeter and submillimeter wave bands. , 2007, Applied optics.

[18]  B. Clark,et al.  The NRAO tape-recorder interferometer system , 1973 .

[19]  Dominic J. Benford,et al.  Far-Infrared Double-Fourier Interferometers and their Spectral Sensitivity , 2015, 1507.03961.

[20]  F. Roddier,et al.  Single-mode fiber optics in a long-baseline interferometer. , 1987, Applied optics.

[21]  David T. Leisawitz,et al.  Recent progress in wide-field imaging interferometry , 2010, Astronomical Telescopes + Instrumentation.

[22]  Kazuyoshi Itoh,et al.  III Interferometric Multispectral Imaging , 1996 .

[23]  H. Philip Stahl,et al.  The Space Infrared Interferometric Telescope (SPIRIT): High- resolution imaging and spectroscopy in the far-infrared , 2007 .

[24]  Munson,et al.  Visible cone-beam tomography with a lensless interferometric camera , 1999, Science.

[25]  Andreas Volkmer,et al.  Vibrational Imaging Based On Stimulated Raman Scattering Microscopy , 2009 .

[26]  W. H. Carter,et al.  Coherence and radiant intensity in scalar wave fields generated by fluctuating primary planar sources , 1978 .

[27]  T. Takahashi,et al.  A 6 × 320-MHz 1024-channel FFT cross-spectrum analyzer for radio astronomy , 1987, Proceedings of the IEEE.

[28]  Kazuyoshi Itoh,et al.  High-speed molecular spectral imaging of tissue with stimulated Raman scattering , 2012, Nature Photonics.

[29]  L. Mandel,et al.  Optical Coherence and Quantum Optics , 1995 .