A theoretical model for the effects of reduced hemoglobin-oxygen affinity on tumor oxygenation.

[1]  E. Shaw,et al.  A phase I study of RSR13, a radiation-enhancing hemoglobin modifier: tolerance of repeated intravenous doses and correlation of pharmacokinetics with pharmacodynamics. , 2001, International journal of radiation oncology, biology, physics.

[2]  T. Secomb,et al.  Theoretical Simulation of Oxygen Transport to Brain by Networks of Microvessels: Effects of Oxygen Supply and Demand on Tissue Hypoxia , 2000, Microcirculation.

[3]  S. Piantadosi,et al.  Phase I trial to determine the safety, pharmacodynamics, and pharmacokinetics of RSR13, a novel radioenhancer, in newly diagnosed glioblastoma multiforme. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  W. Sibbald,et al.  Effects of [Formula: see text] on hemodynamic responses and O2 transport during RSR13-induced reduction in P50. , 1999, American journal of physiology. Heart and circulatory physiology.

[5]  G. Rosner,et al.  The effects of hyperoxic and hypercarbic gases on tumour blood flow , 1999, British Journal of Cancer.

[6]  D. Abraham,et al.  RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice , 1999, British Journal of Cancer.

[7]  J F Gross,et al.  Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels. , 1998, Advances in experimental medicine and biology.

[8]  P. Wagner.  Insensitivity of to hemoglobin-P50 at sea level and altitude , 1997 .

[9]  P. Wagner,et al.  A theoretical analysis of factors determining VO2 MAX at sea level and altitude. , 1996, Respiration physiology.

[10]  G L Rosner,et al.  Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content. , 1996, The British journal of cancer. Supplement.

[11]  D. Abraham,et al.  Low-affinity hemoglobin increases tissue PO2 and decreases arteriolar diameter and flow in the rat cremaster muscle. , 1996, Microvascular research.

[12]  Y. Kakeji,et al.  RSR13: Effects on tumor oxygenation and response to therapy , 1996 .

[13]  R. Schmidt-Ullrich,et al.  Increased radiation response of FSaII fibrosarcomas in C3H mice following administration of an allosteric effector of hemoglobin-oxygen affinity , 1996 .

[14]  J F Gross,et al.  Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. , 1995, Acta oncologica.

[15]  T. Secomb,et al.  Simulation of O2 transport in skeletal muscle: diffusive exchange between arterioles and capillaries. , 1994, The American journal of physiology.

[16]  J F Gross,et al.  Determination of local oxygen consumption rates in tumors. , 1994, Cancer research.

[17]  C. Grau,et al.  Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model. , 1993, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[18]  J F Gross,et al.  Analysis of oxygen transport to tumor tissue by microvascular networks. , 1993, International journal of radiation oncology, biology, physics.

[19]  D. Abraham,et al.  Allosteric modifiers of hemoglobin: 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid derivatives that lower the oxygen affinity of hemoglobin in red cell suspensions, in whole blood, and in vivo in rats. , 1992, Biochemistry.

[20]  M. Dewhirst,et al.  Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber. , 1992, Radiation research.

[21]  D. Hirst,et al.  Chlorophenoxy acetic acid derivatives as hemoglobin modifiers and tumor radiosensitizers. , 1989, International journal of radiation oncology, biology, physics.

[22]  R. Winslow.  Optimal hematologic variables for oxygen transport, including P50, hemoglobin cooperativity, hematocrit, acid-base status, and cardiac function. , 1988, Biomaterials, artificial cells, and artificial organs.

[23]  D. Siemann,et al.  Tumor radiosensitization through reductions in hemoglobin affinity. , 1986, International journal of radiation oncology, biology, physics.

[24]  E. P. Hill,et al.  Theoretical analysis of optimal P50. , 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

[25]  John B. West,et al.  Respiratory Physiology - the Essentials , 1979 .